Phenylacetic acid derivatives, process and intermediate products for their preparation, and their use as fungicides and pesticides

ABSTRACT

Phenylacetic acid derivatives of the formula I                    
     where the variables are as disclosed herein, their salts, processes and intermediates for their preparation, and their use for controlling harmful fungi and animal pests.

This application is a 371 of PCT/EP90/04621, filed Oct. 24, 1996.

The present invention relates to phenylacetic acid derivatives of theformula I

where the variables have the following meanings:

X is NOCH₃, CHOCH₃ or CHCH₃;

Y is O or NZ, Z being hydrogen or C₁-C₄-alkyl;

R¹ is hydrogen or C₁-C₄-alkyl;

R² is cyano, nitro, trifluoromethyl, halogen, C₁-C₄-alkyl orC₁-C₄-alkoxy;

m is 0, 1 or 2, it being possible for the radicals R² to be different ifm is 2;

R³ is hydrogen, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy orcyclopropyl;

R⁴ is C₁-C₄-alkylenedioxy, the alkylene groups being partially or fullyhalogenated, or is one of the radicals:

—(C═O)—R^(a),

—C(═NOR^(a))—A_(p)—R^(b),

—NR^(c)—(C═O)—A_(p)—R^(a),

—O—(C═O)—NR^(a)R^(b) or

—N(R^(c))—OR^(d), where

R^(a), R^(b) independently of one another are hydrogen or in each caseunsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl,cycloalkenyl, heterocyclyl, aryl or hetaryl,

R^(c), R^(d) independently of one another are hydrogen or in each caseunsubstituted or substituted alkyl, alkenyl, alkynyl, alkylcarbonyl,alkenylcarbonyl, alkynylcarbonyl, alkoxycarbonyl, alkenyloxycarbonyl,alkynyloxycarbonyl, cycloalkyl, cycloalkylcarbonyl,cycloalkyloxycarbonyl, arylcarbonyl or hetarylcarbonyl,

p is 0 or 1 and

A is oxygen, sulfur or nitrogen, the nitrogen having attached to ithydrogen or C₁-C₆-alkyl;

n is 1 or 2, it being possible for the radicals R⁴ to be different if nis 2;

R⁵ is hydrogen,

C₁-C₆-alkylsulfonyl, C₁-C₆-alkyl, C₃-C₆-alkenyl, C₃-C₆-alkynyl, it beingpossible for these radicals to be partially or fully halogenated and/orto have attached to them one to three of the following groups: cyano,nitro, hydroxyl, mercapto, amino, carboxyl, aminocarbonyl,aminothiocarbonyl, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₁-C₆-alkylsulfonyl,C₁-C₆-alkylsulfoxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, C₁-C₆-alkylamino,di-C₁-C₆-alkylamino, C₂-C₆-alkenyloxy, C₃-C₆-cycloalkyl,C₃-C₆-cycloalkyloxy, heterocyclyl, heterocyclyloxy, aryl, aryloxy,arylthio, hetaryl, hetaryloxy, hetarylthio, it being possible for thecyclic groups, in turn, to be partially or fully halogenated and/or tohave attached to them one to three of the following substituents: cyano,nitro, hydroxyl, mercapto, amino, carboxyl, aminocarbonyl,aminothiocarbonyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,C₁-C₆-alkylsulfonyl, C₁-C₆-alkylsulfoxyl, C₃-C₆-cycloalkyl,C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio,C₁-C₆-alkylamino, di-C₁-C₆-alkylamino, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy,benzyl, benzyloxy, aryl, aryloxy, arylthio, hetaryl, hetaryloxy,hetarylthio and C₃-C₆-alkynyloxy;

C₃-C₆-cycloalkyl, which can be partially or fully halogenated and/or,independently of each other, can have attached to it one to three of thefollowing groups: cyano, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl,C₁-C₆-alkoxy and C₁-C₆-alkylthio,

and to salts thereof.

Moreover, the invention relates to processes and intermediates for thepreparation of these compounds and to their use for controlling animalpests and harmful fungi.

Phenylacetic acid derivatives for pest control have been disclosed inthe literature (cf. WO-A 95/18789, WO-A 95/21153, WO-A 95/21154), butthey are not yet satisfactory with a view to their activity.

It is an object of the present invention to provide novel compounds ofthis type which have an improved activity.

We have found that this object is achieved by the phenylacetic acidderivatives I defined at the outset. Moreover, we have found processesand intermediates for their preparation, compositions comprising themfor controlling animal pests and harmful fungi, and their use for thesepurposes.

The compounds I are accessible via various routes by processes known perse.

When synthesizing the compounds I, it is, in principle, irrelevantwhether the group —C(X)—CO—Y—R¹ or the group

is first synthesized.

The synthesis of the group —C(X)—CO—Y—R¹ is disclosed, for example, inthe publications cited at the outset and in the following: EP-A 242 070,EP-A 254 426, EP-A 370 629, EP-A 398 692, EP-A 422 597, EP-A 463 488,EP-A 472 300, EP-A 513 580, EP-A 656 352, German Application P 44 20416.7.

When synthesizing the group

a procedure is generally followed in which a benzyl derivative of theformula II is reacted with a hydroxyimine of the formula III.

L¹ in formula II is a nucleophilically exchangeable leaving group, eg.halogen or sulfonate groups, preferably chlorine, bromine, iodine,mesylate, tosylate or triflate.

The reaction is carried out in a manner known per se in an inert organicsolvent in the presence of a base, eg. sodium hydride, potassiumhydroxide, potassium carbonate or triethylamine, following the methodsdescribed in Houben-Weyl, 4th Edition, Vol. E 14b, p. 370 et seq. andibd. Vol. 10/1, p. 1189 et seq.

The hydroxyimine III which is required is obtained, for example, byreacting a corresponding dihydroxyimine IV with the compound of theformula VI

L² in formula VI is a nucleophilically exchangeable leaving group, eg.halogen or sulfonate groups, preferably chlorine, bromine, iodine,mesylate, tosylate or triflate.

The reaction is carried out in a manner known per se in an inert organicsolvent in the presence of a base, eg. potassium carbonate, potassiumhydroxide, sodium hydride, pyridine or triethylamine as described in:Houben-Weyl, 4th Edition, Vol. E 14b, p. 307 et seq., p. 370 et seq. andp. 385 et seq.; ibid., 4th Edition, Vol. 10/4, p. 55 et seq., p. 180 etseq. and p. 217 et seq.; ibid., 4th Edition, Vol. E 5, p. 780 et seq.

Those compounds of the formula IV which are not already known can beprepared by methods known per se (cf. Gazz. Chim. Ital. 59 (1929), 719;Collect. Bull. Soc. Chim. Fr. 17 (1897), 71).

Alternatively, the compounds I can also be obtained by reacting thebenzyl derivative II first with the dihydroxyimino derivative IV to givea corresponding benzyl oxime of the formula V, V subsequently beingreacted with a compound of a [sic] formula VI to give I.

The reaction is carried out in a manner known per se in an inert organicsolvent in the presence of a base, eg. potassium carbonate, potassiumhydroxide, sodium hydride, pyridine or triethylamine following themethods described in Houben-weyl, 4th Edition, Vol. 10/1, p. 1189 etseq., Vol. E 14b, p. 307 et seq., p. 370 et seq. and p. 385 et seq.,Vol. 10/4, p. 55 et seq., p. 180 et seq. and p. 217 et seq., Vol. E 5,p. 780 et seq.

Similarly, it is also possible to prepare the hydroxyimine [sic] of theformula III which is required from a carbonylhydroxyimine VII byreacting the latter with a hydroxylamine IXa or a salt thereof IXb.

Q^(⊖) in formula IXb is the anion of an acid, in particular of aninorganic acid, eg. halide, such as chloride.

The reaction is carried out in a manner known per se in an inert organicsolvent following the methods described in EP-A 513 580; Houben-Weyl,4th Edition, Vol. 10/4, p. 73 et seq., Vol. E 14b, p. 369 et seq. and p.385 et seq.

Those compounds of the formula VII which are not already known can beprepared by methods known per se (J. Am. Pharm. Assoc. 35 (1946), 15).

Alternatively, the compounds I can also be obtained by reacting thebenzyl derivative II first with the carbonylhydroxyimino derivative VIIto give a corresponding benzyloxyimine of the formula VIII, VIIIsubsequently being reacted with the hydroxylamine IXa or the saltthereof IXb to give I.

The reaction is carried out in a manner known per se in an inert organicsolvent following the methods described in Houben-Weyl, 4th Edition,Vol. E 14b, p. 369 et seq., Vol. 10/1, p. 1189 et seq. and Vol. 10/4, p.73 et seq. or EP-A 513 580.

A further possibility of preparing the compounds I where R³ is notC₁-C₄-alkoxy is to react the benzyl derivative II withN-hydroxyphthalimide, subsequently subjecting the product tohydrazinolysis to give the benzylhydroxylamine IIa and further reactingIIa with a carbonyl compound X.

The reaction is carried out in a manner known per se in an inert organicsolvent following the methods described in EP-A 463 488 and EP-A 585751.

The carbonyl compound X which is required is obtained, for example, byreacting a corresponding hydroxyiminocarbonyl compound VIIa with acompound of the formula VI

or by reacting a corresponding dicarbonyl compound XI with ahydroxylamine IXa or a salt thereof IXb

The reactions are carried out in a manner known per se in an inertorganic solvent following the methods described in EP-A 513 580,Houben-Weyl, 4th Edition, Vol. 10/4, p. 55 et seq., p. 73 et seq., p.180 et seq. and p. 217 et seq., Vol. E 14b, p. 307 ff and 369 et seq.,Vol. E 5, p. 780 et seq.

Those compounds of the formula VIIa or XI which are not already knowncan be prepared by methods known per se (J. Chem. Soc., 3094 (1955);Bull. Soc. Chim. Fr., 2894 (1969); Tetrahedron 40 (1984), 2035).

Similarly, the compounds I can also be obtained by first reacting thebenzylhydroxylamine IIa with the hydroxyimino derivative VIIa to givethe corresponding benzyloxyimino derivative of the formula V, Vsubsequently being reacted with a compound of the formula VI asdescribed above to give I.

Similarly, the compounds I can also be prepared by first converting thebenzylhydroxylamine IIa with the dicarbonyl derivative of the formula XIto give the benzyloxyimino derivative of the formula VIII andsubsequently reacting VIII with the hydroxylamine IXa or a salt thereofIXb as described above to give I.

Furthermore, the compounds I are also obtained by first converting acompound III with a lactone XII following the methods described in EP-A493 711 to give the corresponding benzoic acid XIII and converting XIIIinto the cyanocarboxylic acids XIV via the corresponding halides, andthe cyanocarboxylic acids XIV are converted into the α-ketoesters XV viaa Pinner reaction (Angew. Chem. 94 (1982), 1) and, if desired, theα-ketoesters XV are reacted further to give the α-ketoamides XVI (cf.EP-A 348 766, DE-A 37 05 389, EP-A 178 826, DE-A 36 23 921, Houben-Weyl,4th dition, Vol. E5, p. 941 et seq.).

The α-ketoesters XV and the α-ketoamides XVI can be converted into thecompounds I following customary methods (cf. EP-A 178 826, EP-A 513 580,DE-A 36 23 921, EP-A 398 692).

Compounds I where R¹ is hydrogen are obtained by this process by meansof hydrolyzing the esters XV and subsequent reaction to give I.

The compounds I where R⁴ is —C(═NOR^(a))—R^(b),—NR^(c)—(C═O)—A_(p)—R^(a), —O—(C═O)—NR^(a)R^(b) or —N(R^(c))—OR^(d) arepreferably synthesized by generally known methods starting from thecompounds XVII, XVIII, XIX or XX.

The compounds I where Y is NH can also be obtained from thecorresponding esters (Y═O) by reacting the latter with amines of theformula R¹NH₂.

Those compounds II which are not already known (EP-A 513 580, EP-A 477631, EP-A 463 488, EP-A 251 082, EP-A 400 417, EP-A 585 751) can beprepared following the methods described in these publications.

Owing to their C═C and C═N double bonds, the compounds I can be obtainedfrom their preparation as E/Z isomer mixtures, which can be separatedinto the individual compounds in the customary manner, for example bycrystallization or chromatography.

If isomer mixtures are obtained from the synthesis, however, aseparation is generally not absolutely necessary since in some cases theindividual isomers can be converted into each other during formulationfor use or upon use (eg. when exposed to light, acids or bases). Similarconversions can also take place after use, for example in the case ofthe treatment of plants in the treated plants or in the harmful fungusor animal pest to be controlled.

As regards the C═X double bond, the E isomers of the compounds I arepreferred with a view to their activity (configuration based on the—OCH₃ or the —CH₃ group relative to the —CO—Y—R¹ group).

As regards the —C(R³)═NOCH₂— double bond, the cis isomers of thecompounds I are preferred with a view to their activity (configurationbased on the radical R³ relative to the —OCH₂ group).

In the definitions of the compounds I given at the outset, collectiveterms were used which generally represent the following groups:

Halogen: fluorine, chlorine, bromine and iodine;

Alkyl: straight-chain or branched alkyl groups having 1 to 4, 6 or 10carbon atoms, eg. C₁-C₆-alkyl, such as methyl, ethyl, propyl,1-methylethyl, butyl, 1-methyl-propyl, 2-methylpropyl,1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl,2,2-di-methylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl,1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl,4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl,2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl,2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl,1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl;

Alkylamino: an amino group which has attached to it a straight-chain orbranched alkyl group having 1 to 6 carbon atoms as mentioned above;

Dialkylamino: an amino group which has attached to it two straight-chainor branched alkyl groups which are independent of each other and have ineach case 1 to 6 carbon atoms as mentioned above;

Alkylcarbonyl: straight-chain or branched alkyl groups having 1 to 10carbon atoms which are linked to the skeleton via a carbonyl group(—CO—);

Alkylsulfonyl: straight-chain or branched alkyl groups having 1 to 6 or10 carbon atoms which are linked to the skeleton via a sulfonyl group(—SO₂—);

Alkylsulfoxyl: straight-chain or branched alkyl groups having 1 to 6carbon atoms which are linked to the skeleton via a sulfoxyl group(—S(═O)—);

Alkylaminocarbonyl: alkylamino groups having 1 to 6 carbon atoms asmentioned above which are linked to the skeleton via a carbonyl group(—CO—);

Dialkylaminocarbonyl: dialkylamino groups having in each case 1 to 6carbon atoms per alkyl radical as mentioned above which are linked tothe skeleton via a carbonyl group (—CO—);

Alkylaminothiocarbonyl: alkylamino groups having 1 to 6 carbon atoms asmentioned above which are linked to the skeleton via a thiocarbonylgroup (—CS—);

Dialkylaminothiocarbonyl: dialkylamino groups having in each case 1 to 6carbon atoms per alkyl radical as mentioned above which are linked tothe skeleton via a thiocarbonyl group (—CS—);

Haloalkyl: straight-chain or branched alkyl groups having 1 to 6 carbonatoms, it being possible for some or all of the hydrogen atoms in thesegroups to be replaced by halogen atoms as mentioned above, eg.C₁-C₂-haloalkyl, such as chloromethyl, dichloromethyl, trichloromethyl,fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl,dichlorofluoromethyl, chlorodifluoromethyl, 1-fluoroethyl,2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl,2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl,2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl and pentafluoroethyl;

Alkoxy: straight-chain or branched alkyl groups having 1 to 4 or 6carbon atoms as mentioned above which are linked to the skeleton via anoxygen atom (—O—), eg. C₁-C₆-alkoxy, such as methyloxy, ethyloxy,propyloxy, 1-methylethyloxy, butyloxy, 1-methylpropyloxy,2-methylpropyloxy, 1,1-dimethylethyloxy, pentyloxy, 1-methylbutyloxy,2-methylbutyloxy, 3-methylbutyloxy, 2,2-di-methylpropyloxy,1-ethylpropyloxy, hexyloxy, 1,1-dimethylpropyloxy,1,2-dimethylpropyloxy, 1-methylpentyloxy, 2-methylpentyloxy,3-methylpentyloxy, 4-methylpentyloxy, 1,1-dimethylbutyloxy,1,2-dimethylbutyloxy, 1,3-dimethylbutyloxy, 2,2-dimethylbutyloxy,2,3-dimethylbutyloxy, 3,3-dimethylbutyloxy, 1-ethyl-butyloxy,2-ethylbutyloxy, 1,1,2-trimethylpropyloxy, 1,2,2-trimethylpropyloxy,1-ethyl-1-methylpropyloxy and 1-ethyl-2-methylpropyloxy;

Alkoxycarbonyl: straight-chain or branched alkyl groups having 1 to 6carbon atoms which are linked to the skeleton via an oxycarbonyl group(—OC(═O)—);

Haloalkoxy: straight-chain or branched alkyl groups having 1 to 6 carbonatoms, it being possible for some or all of the hydrogen atoms in thesegroups to be replaced by halogen atoms as mentioned above, and thesegroups being linked to the skeleton via an oxygen atom;

Alkylthio: straight-chain or branched alkyl groups having 1 to 4 or 6carbon atoms as mentioned above which are linked to the skeleton via asulfur atom (—S—), eg. C₁-C₆-alkylthio, such as methylthio, ethylthio,propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio,2-methylpropylthio, 1,1-dimethylethylthio, pentylthio,1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio,2,2-di-methylpropylthio, 1-ethylpropylthio, hexylthio,1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1-methylpentylthio,2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio,1,1-dimethylbutylthio, 1,2-dimethylbutylthio, 1,3-dimethylbutylthio,2,2-dimethylbutylthio, 2,3-dimethylbutylthio, 3,3-dimethylbutylthio,1-ethylbutylthio, 2-ethylbutylthio, 1,1,2-trimethylpropylthio,1,2,2-trimethylpropylthio, 1-ethyl-1-methylpropylthio and1-ethyl-2-methylpropylthio;

Alkylenedioxy: divalent branched or unbranched chains of 1-4 CH₂ groupswhich may be partially or fully halogenated, and both valencies arelinked to the skeleton via an oxygen atom, eg. OCH₂—O, O—CH₂CH₂—O,O—CHCl—CHCl—O— or O—(CH₂)₃—O;

Cycloalkyl: monocyclic alkyl groups having 3 to 6 carbon ring members,eg. cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl;

Alkenyl: straight-chain or branched alkenyl groups having 2 to 6 or 10carbon atoms and a double bond in any position, eg. C₂-C₆-alkenyl, suchas ethenyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl,2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl,1-methyl-2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl,3-pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl,3-methyl-1-butenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl,3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl,3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-1-propenyl,1,2-dimethyl-2-propenyl, 1-ethyl-1-propenyl, 1-ethyl-2-propenyl,1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl,1-methyl-1-pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl,4-methyl-1-pentenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl,3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 1-methyl-3-pentenyl,2-methyl-3-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl,1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl,4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-di-methyl-3-butenyl,1,2-dimethyl-1-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl,1,3-dimethyl-2-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl,2,2-dimethyl-3-butenyl, 2,3-dimethyl-3-butenyl, 2,3-dimethyl-2-butenyl,2,3-dimethyl-3-butenyl, 3,3-dimethyl-1-butenyl, 3,3-dimethyl-2-butenyl,1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl,2-ethyl-1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl,1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl,1-ethyl-2-methyl-1-propenyl and 1-ethyl-2-methyl-2-propenyl;

Alkenyloxy: straight-chain or branched alkenyl groups having 2 to 6carbon atoms and a double bond in any position which are linked to theskeleton via an oxygen atom (—O—);

Alkenylthio and alkenylamino: straight-chain or branched alkenyl groupshaving 2 to 6 carbon atoms and a double bond in any position which arelinked to the skeleton via a sulfur atom (alkenylthio) or a nitrogenatom (alkenylamino);

Alkenylcarbonyl: straight-chain or branched alkenyl groups having 2 to10 carbon atoms and a double bond in any position which are linked tothe skeleton via a carbonyl-group (—CO—);

Alkynyl: straight-chain or branched alkynyl groups having 2 to 10 carbonatoms and a triple bond in any position, eg. C₂-C₆-alkynyl, such asethynyl, 2-propynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl,2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl,1-methyl-3-butynyl, 2-methyl-3-butynyl, 1,1-dimethyl-2-propynyl,1-ethyl-2-propynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl,1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl,2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-4-pentynyl,4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl,1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 1-ethyl-2-butynyl,1-ethyl-3-butynyl, 2-ethyl-3-butynyl and 1-ethyl-1-methyl-2-propynyl;

Alkynyloy, or alkynylthio and alkynylamino: straight-chain or branchedalkynyl groups having 2 to 6 carbon atoms and a triple bond in anyposition which are linked to the skeleton via an oxygen atom(alkynyloxy), via a sulfur atom (alkynylthio) or via a nitrogen atom(alkynylamino).

Alkynylcarbonyl: straight-chain or branched alkynyl groups having 3 to10 carbon atoms and a triple bond in any position which are linked tothe skeleton via a carbonyl group (—CO—);

Cycloalkenyl, or cycloalkenyloxy, cycloalkenylthio andcycloalkenylamino: monocyclic alkenyl groups having 3 to 6 carbon ringmembers which are linked to the skeleton directly or via an oxygen atom(cycloalkenyloxy) or a sulfur atom (cycloalkenylthio) or via a nitrogenatom (cycloalkenylamino), eg. cyclopropenyl, cyclobutenyl, cyclopentenylor cyclohexenyl;

Cycloalkyloxy, or cycloalkylthio and cycloalkylamino: monocyclic alkylgroups having 3 to 6 carbon ring members which are linked to theskeleton via an oxygen atom (cycloalkyloxy) or a sulfur atom(cycloalkylthio) or via a nitrogen atom (cycloalkylamino), eg.cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl;

Cycloalkylcarbonyl: cycloalkyl groups as defined above which are linkedto the skeleton via a carbonyl group (—CO—);

Cycloalkyloxycarbonyl: cycloalkyloxy groups as defined above which arelinked to the skeleton via a carbonyl group (—CO—);

Alkenyloxycarbonyl: alkenyloxy groups as defined above which are linkedto the skeleton via a carbonyl group (—CO—);

Alkynyloxycarbonyl: alkynyloxy groups as defined above which are linkedto the skeleton via a carbonyl group (—CO—);

Heterocyclyl, or Heterocyclyl, heterocyclylthio and heterocyclylamino:three- to six-membered saturated or partially unsaturated mono- orpolycyclic heterocycles which contain one to three hetero atoms selectedfrom a group consisting of oxygen, nitrogen and sulfur and which arelinked to the skeleton directly, or via an oxygen atom (heterocyclyloxy)or via a sulfur atom (heterocyclylthio) or via a nitrogen atom(heterocyclylamino), eg. 2-tetrahydrofuranyl, oxiranyl,3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3-tetrahydrothienyl,2-pyrrolidinyl, 3-pyrrolidinyl, 3-isoxazoldinyl [sic], 4-isoxazolidinyl,5-isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl,5-isothiazolidinyl, 3-pyrazolidinyl, 4-pyrazolidinyl, 5-pyrazolidinyl,2-oxazolidinyl, 4-oxazolidinyl, 5-oxazolidinyl, 2-thiazolidinyl,4-thiazolidinyl, 5-thiazolidinyl, 2-imidazolidinyl, 4-imidazolidinyl,1,2,4-oxadiazolidin-3-yl, 1,2,4-oxadiazolidin-5-yl,1,2,4-thiadiazolidin-3-yl, 1,2,4-thiadiazolidin-5-yl,1,2,4-triazolidin-3-yl, 1,3,4-oxadiazolidin-2-yl,1,3,4-thiadiazolidin-2-yl, 1,3,4-triazolidin-2-yl, 2,3-dihydrofur-2-yl,2,3-dihydrofur-3-yl, 2,3-dihydro-fur-4-yl, 2,3-dihydro-fur-5-yl,2,5-dihydro-fur-2-yl, 2,5-dihydro-fur-3-yl, 2,3-dihydrothien-2-yl,2,3-dihydrothien-3-yl, 2,3-dihydrothien-4-yl, 2,3-dihydrothien-5-yl,2,5-dihydrothien-2-yl, 2,5-dihydrothien-3-yl, 2,3-dihydropyrrol-2-yl,2,3-dihydropyrrol-3-yl, 2,3-dihydropyrrol-4-yl, 2,3-dihydropyrrol-5-yl,2,5-dihydropyrrol-2-yl, 2,5-dihydropyrrol-3-yl,2,3-dihydroisoxazol-3-yl, 2,3-dihydroisoxazol-4-yl,2,3-dihydroisoxazol-5-yl, 4,5-dihydroisoxazol-3-yl,4,5-dihydroisoxazol-4-yl, 4,5-dihydroisoxazol-5-yl,2,5-dihydroisothiazol-3-yl, 2,5-dihydroisothiazol-4-yl,2,5-dihydroisothiazol-5-yl, 2,3-dihydroisopyrazol-3-yl,2,3-dihydroisopyrazol-4-yl, 2,3-dihydroisopyrazol-5-yl,4,5-dihydroisopyrazol-3-yl, 4,5-dihydroisopyrazol-4-yl,4,5-dihydroisopyrazol-5-yl, 2,5-dihydroisopyrazol-3-yl,2,5-dihydroisopyrazol-4-yl, 2,5-dihydroisopyrazol-5-yl,2,3-dihydrooxazol-3-yl, 2,3-dihydrooxazol-4-yl, 2,3-dihydrooxazol-5-yl,4,5-dihydrooxazol-3-yl, 4,5-dihydrooxazol-4-yl, 4,5-dihydrooxazol-5-yl,2,5-dihydrooxazol-3-yl, 2,5-dihydrooxazol-4-yl, 2,5-dihydrooxazol-5-yl,2,3-dihydrothiazol-2-yl, 2,3-dihydrothiazol-4-yl,2,3-dihydrothiazol-5-yl, 4,5-dihydrothiazol-2-yl,4,5-dihydrothiazol-4-yl, 4,5-dihydrothiazol-5-yl,2,5-dihydrothiazol-2-yl, 2,5-dihydrothiazol-4-yl,2,5-dihydrothiazol-5-yl, 2,3-dihydroimidazol-2-yl,2,3-dihydroimidazol-4-yl, 2,3-dihydroimidazol-5-yl,4,5-dihydroimidazol-2-yl, 4,5-dihydroimidazol-4-yl,4,5-dihydroimidazol-5-yl, 2,5-dihydroimidazol-2-yl,2,5-dihydroimidazol-4-yl, 2,5-dihydroimidazol-5-yl, 2-morpholinyl,3-morpholinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl,3-tetrahydropyridazinyl, 4-tetrahydropyridazinyl,2-tetrahydropyrimidinyl, 4-tetrahydropyrimidinyl,5-tetrahydropyrimidinyl, 2-tetrahydropyrazinyl,1,3,5-tetrahydrotriazin-2-yl, 1,2,4-tetrahydrotriazin-3-yl,1,3-dihydrooxazin-2-yl, 1,3-dithian-2-yl, 2-tetrahydropyranyl,1,3-dioxolan-2-yl, 3,4,5,6-tetrahydropyridin-2-yl, 4H-1,3-thiazin-2-yl,4H-3,1-benzothiazin-2-yl, 1,1-dioxo-2,3,4,5-tetrahydrothien-2-yl,2H-1,4-benzothiazin-3-yl, 2H-1,4-benzoxazin-3-yl,1,3-dihydrooxazin-2-yl, 1,3-dithian-2-yl,

Aryl, or aryloxy, arylthio, arylcarbonyl and arylsulfonyl: aromaticmono- or polycyclic hydrocarbon radicals which are linked to theskeleton directly, or (aryloxy) via an oxygen atom (—O—), or (arylthio)via a sulfur atom (—S—), or (arylcarbonyl) via a carbonyl group (—CO—)or (arylsulfonyl) via a sulfonyl group (—SO₂—), eg. phenyl, naphthyl andphenanthrenyl, or phenyloxy, naphthyloxy and phenanthrenyloxy and thecorresponding carbonyl and sulfonyl radicals;

Arylamino: aromatic mono- or polycyclic hydrocarbon radicals which arelinked to the skeleton via a nitrogen atom;

Hetaryl, or hetaryloxy, hetarylthio, hetarylcarbonyl andhetarylsulfonyl: aromatic mono- or polycyclic radicals which, besidescarbon ring members, can additionally contain one to four nitrogen atomsor one to three nitrogen atoms and one oxygen or one sulfur atom or oneoxygen or one sulfur atom and which are linked to the skeleton directly,or (hetaryloxy) via an oxygen atom (—O—) or (hetarylthio) via a sulfuratom (—S—), (hetarylcarbonyl) via a carbonyl group (—CO—) or(hetarylsulfonyl) via a sulfonyl group (—SO₂—), eg.

5-membered hetaryl containing one to three nitrogen atoms: 5-memberedhetaryl ring groups which, besides carbon atoms, can contain one tothree nitrogen atoms as ring members, eg. 2-pyrrolyl, 3-pyrrolyl,3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 2-imidazolyl, 4-imidazolyl,1,2,4-triazol-3-yl and 1,3,4-triazol-2-yl;

5-membered hetaryl containing one to four nitrogen atoms or one to threenitrogen atoms and one sulfur or oxygen atom or one oxygen or one sulfuratom: 5-membered hetaryl ring groups which, besides carbon atoms, cancontain one to four nitrogen atoms or one to three nitrogen atoms andone sulfur or oxygen atom or one oxygen or sulfur atom as ring members,eg. 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyrrolyl, 3-pyrrolyl,3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, 3-isothiazolyl,4-isothiazolyl, 5-isothiazolyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl,2-oxazolyl, 4-oxazolyl, 5-oxazolyl, 2-thiazolyl, 4-thiazolyl,5-thiazolyl, 2-imidazolyl, 4-imidazolyl, 1,2,4-oxadiazol-3-yl,1,2,4-oxadiazol-5-yl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl,1,2,4-triazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,3,4-thiadiazol-2-yl,1,3,4-triazol-2-yl;

benzo-fused 5-membered hetaryl containing one to three nitrogen atoms orone nitrogen atom and/or one oxygen or sulfur atom: 5-membered hetarylring groups which, besides carbon atoms, can contain one to fournitrogen atoms or one to three nitrogen atoms and one sulfur or oxygenatom or one oxygen or one sulfur atom as ring members, and in which twoadjacent carbon ring members or one nitrogen and an adjacent carbon ringmember can be bridged by a buta-1,3-diene-1,4-diyl group;

5-membered hetaryl, linked via nitrogen and containing one to 4 nitrogenatoms, or benzo-fused 5-membered hetaryl linked via nitrogen andcontaining one to three nitrogen atoms: 5-membered hetaryl ring groupswhich, besides carbon atoms, can contain one to four nitrogen atoms, orone to three nitrogen atoms, respectively, as ring members and in whichtwo adjacent carbon ring members or one nitrogen and an adjacent carbonring member can be bridged by a buta-1,3-diene-1,4-diyl group, theserings being linked to the skeleton via one of the nitrogen ring members;

6-membered hetaryl containing one to three, or one to four, nitrogenatoms: 6-membered hetaryl ring groups which, besides carbon ringmembers, can contain one to three, or one to four, nitrogen atoms,respectively, as ring members, eg. 2-pyridinyl, 3-pyridinyl,4-pyridinyl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl,5-pyrimidinyl, 2-pyrazinyl, 1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl and1,2,4,5-tetrazin-3-yl;

benzo-fused 6-membered hetaryl containing one to four nitrogen atoms:6-membered hetaryl ring groups in which two adjacent carbon ring memberscan be bridged by a buta-1,3-diene-1,4-diyl group, eg. quinoline,isoquinoline, quinazoline and quinoxaline,

and the corresponding oxy, thio, carbonyl or sulfonyl groups.

Netarylamino: aromatic mono- or polycyclic radicals which, besidescarbon ring members, can additionally contain one to four nitrogen atomsor one to three nitrogen atoms and one oxygen or one sulfur atom andwhich are linked to the skeleton via a nitrogen atom.

The term “partially or fully halogenated” is intended to express thatsome or all of the hydrogen atoms in thus characterized groups can bereplaced by identical or different halogen atoms as mentioned above.

Compounds I which are preferred for their biological activity are thosewhere R^(a) and R^(b) independently of one another are:

hydrogen;

C₁-C₆-alkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, it being possible for theseradicals to be partially or fully halogenated and/or to have attached tothem one to three of the following groups: cyano, nitro, hydroxyl,mercapto, amino, carboxyl, aminocarbonyl, aminothiocarbonyl,C₁-C₆-alkylaminocarbonyl, di-C₁-C₆-alkylaminocarbonyl,C₁-C₆-alkylaminothiocarbonyl, di-C₁-C₆-alkylaminothiocarbonyl,C₁-C₆-alkylsulfonyl, C₁-C₆-alkylsulfoxyl, C₁-C₆-alkoxy,C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio,C₁-C₆-alkylamino, di-C₁-C₆-alkylamino, C₂-C₆-alkenyloxy,C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, heterocyclyl, heterocyclyloxy,aryl, aryloxy, arylthio, hetaryl, hetaryloxy, hetarylthio, it beingpossible for the cyclic groups, in turn, to be partially or fullyhalogenated and/or to have attached to them one to three of thefollowing substituents: cyano, nitro, hydroxyl, mercapto, amino,carboxyl, aminocarbonyl, aminothiocarbonyl, C₁-C₆-alkyl,C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylsulfonyl,C₁-C₆-alkylsulfoxyl, C₃-C₆-cycloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, C₁-C₆-alkylamino,di-C₁-C₆-alkylamino, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy,benzyl, benzyloxy, aryl, aryloxy, arylthio, hetaryl, hetaryloxy,hetarylthio and C₃-C₆-alkynyloxy;

C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, heterocyclyl, it being possiblefor these radicals to be partially or fully halogenated and/or to haveattached to them one to three of the following groups: cyano,C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl, C₁-C₆-alkoxy andC₁-C₆-alkylthio; aryl or hetaryl, it being possible for these radicals,in turn, to be partially or fully halogenated and/or to have attached tothem one to three of the following groups: cyano, nitro, hydroxyl,mercapto, amino, carboxyl, aminocarbonyl, aminothiocarbonyl,C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylsulfonyl,C₁-C₆-alkylsulfoxyl, C₃-C₆-cycloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, C₁-C₆-alkylamino,Di-C₁-C₆-alkylamino, C₁-C₆-alkylaminocarbonyl,Di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,Di-C₁-C₆-alkylaminothiocarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy,benzyl, benzyloxy, aryl, aryloxy, arylthio, hetaryl, hetaryloxy,hetarylthio, C₃-C₆-alkynyloxy and C₁-C₄-alkylenedioxy or halogenatedC₁-C₄-alkylenedioxy.

Other preferred compounds I are those where R^(c) and R^(d)independently of one another are:

hydrogen;

C₁-C₆-alkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, C₁-C₆-alkylcarbonyl,C₂-C₆-alkenylcarbonyl, C₂-C₆-alkynylcarbonyl, C₁-C₆-alkoxycarbonyl,C₂-C₆-alkenyloxycarbonyl, C₂-C₆-alkynyloxycarbonyl, it being possiblefor these radicals to be partially or fully halogenated and/or to haveattached to them one to three of the following groups: cyano, nitro,hydroxyl, mercapto, amino, carboxyl, aminocarbonyl, aminothiocarbonyl,C₁-C₆-alkylaminocarbonyl, di-C₁-C₆-alkylaminocarbonyl,C₁-C₆-alkylaminothiocarbonyl, di-C₁-C₆-alkylaminothiocarbonyl,C₁-C₆-alkylsulfonyl, C₁-C₆-alkylsulfoxyl, C₁-C₆-alkoxy,C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio,C₁-C₆-alkylamino, di-C₁-C₆-alkylamino, C₂-C₆-alkenyloxy,C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, heterocyclyl, heterocyclyloxy,aryl, aryloxy, arylthio, hetaryl, hetaryloxy, hetarylthio, it beingpossible for the cyclic groups, in turn, to be partially or fullyhalogenated and/or to have attached to them one to three of thefollowing substituents: cyano, nitro, hydroxyl, mercapto, amino,carboxyl, aminocarbonyl, aminothiocarbonyl, C₁-C₆-alkyl,C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylsulfonyl,C₁-C₆-alkylsulfoxyl, C₃-C₆-cycloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, C₁-C₆-alkylamino,di-C₁-C₆-alkylamino, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy,benzyl, benzyloxy, aryl, aryloxy, arylthio, hetaryl, hetaryloxy,hetarylthio and C₃-C₆-alkynyloxy;

C₃-C₆-cycloalkyl, cycloalkylcarbonyl, cycloalkyloxycarbonyl, it beingpossible for these radicals to be partially or fully halogenated and/orto have attached to them one to three of the following groups: cyano,C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl, C₁-C₆-alkoxy andC₁-C₆-alkylthio;

arylcarbonyl or hetarylcarbonyl, it being possible for these radicals,in turn, to be partially or fully halogenated and/or to have attached tothem one to three of the following groups: cyano, nitro, hydroxyl,mercapto, amino, carboxyl, aminocarbonyl, aminothiocarbonyl,C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylsulfonyl,C₁-C₆-alkylsulfoxyl, C₃-C₆-cycloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, C₁-C₆-alkylamino,di-C₁-C₆-alkylamino, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy,benzyl, benzyloxy, aryl, aryloxy, arylthio, hetaryl, hetaryloxy,hetarylthio, C₃-C₆-alkynyloxy and C₁-C₄-alkylenedioxy or halogenatedC₁-C₄-alkylenedioxy.

Moreover, preferred compounds I are those where R⁵ is:

hydrogen;

C₁-C₆-alkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, it being possible for theseradicals to be partially or fully halogenated or to have attached tothem one to three of the following groups: cyano, hydroxyl,C₁-C₆-alkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, C₃-C₆-cycloalkyl oroxiranyl, it being possible for the cyclic groups, in turn, to haveattached to them one to five of the following substituents: halogen andC₁-C₄-alkyl.

Especially preferred compounds I are those where R^(a) and R^(b)independently of one another are:

hydrogen;

C₁-C₆-alkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, it being possible for theseradicals to be partially or fully halogenated and/or to have attached tothem one to three of the following groups: cyano, nitro, hydroxyl,C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio,C₂-C₆-alkenyloxy, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, heterocyclyl,heterocyclyloxy, aryl, aryloxy, hetaryl, hetaryloxy, it being possiblefor the cyclic groups, in turn, to be partially or fully halogenatedand/or to have attached to them one to three of the followingsubstituents: cyano, nitro, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,C₁-C₆-alkylcarbonyl, C₃-C₆-cycloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, C₁-C₆-alkylamino,di-C₁-C₆-alkylamino, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy andC₃-C₆-alkynyloxy;

C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, heterocyclyl, it being possiblefor these radicals to be partially or fully halogenated and/or to haveattached to them one to three of the following groups: cyano,C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl, C₁-C₆-alkoxy andC₁-C₆-alkylthio;

aryl or hetaryl, it being possible for these radicals, in turn, to bepartially or fully halogenated and/or to have attached to them one tothree of the following groups: cyano, nitro, hydroxyl, C₁-C₆-alkyl,C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₃-C₆-cycloalkyl, C₁-C₆-alkoxy,C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio,C₁-C₆-alkylamino, di-C₁-C₆-alkylamino, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy,C₃-C₆-alkynyloxy and C₁-C₄-alkylenedioxy or halogenatedC₁-C₄-alkylenedioxy.

Furthermore, especially preferred compounds I are those where R^(c) andR^(d) independently of one another are:

hydrogen;

C₁-C₆-alkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, C₁-C₆-alkylcarbonyl,C₂-C₆-alkenylcarbonyl, C₂-C₆-alkynylcarbonyl, C₁-C₆-alkoxycarbonyl,C₂-C₆-alkenyloxycarbonyl, C₂-C₆-alkynyloxycarbonyl, it being possiblefor these radicals to be partially or fully halogenated and/or to haveattached to them one to three of the following groups: cyano, nitro,hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,C₁-C₆-alkylthio, C₂-C₆-alkenyloxy, C₃-C₆-cycloalkyl,C₃-C₆-cycloalkyloxy, heterocyclyl, heterocyclyloxy, aryl, aryloxy,hetaryl, hetaryloxy, it being possible for the cyclic groups, in turn,to be partially or fully halogenated and/or to have attached to them oneto three of the following substituents: cyano, nitro, hydroxyl,C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₃-C₆-cycloalkyl,C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio,C₁-C₆-alkylamino, di-C₁-C₆-alkylamino, C₂-C₆-alkenyl, C₂-C₆-alkenyloxyand C₃-C₆-alkynyloxy;

C₃-C₆-cycloalkyl, cycloalkylcarbonyl, cycloalkyloxycarbonyl, it beingpossible for these radicals to be partially or fully halogenated and/orto have attached to them one to three of the following groups: cyano,C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl, C₁-C₆-alkoxy andC₁-C₆-alkylthio;

arylcarbonyl or hetarylcarbonyl, it being possible for these radicals,in turn, to be partially or fully halogenated and/or to have attached tothem one to three of the following groups: cyano, nitro, hydroxyl,C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₃-C₆-cycloalkyl,C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio,C₁-C₆-alkylamino, di-C₁-C₆-alkylamino, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy,C₃-C₆-alkynyloxy and C₁-C₄-alkylenedioxy or halogenatedC₁-C₄-alkylenedioxy.

Furthermore, preferred compounds of the formula I are those where m is0.

Equally, preferred compounds of the formula I are those where R¹ ismethyl.

Other preferred compounds I are those where R¹ is hydrogen.

Besides, preferred compounds I are those where R³ is hydrogen,cyclopropyl, methyl, ethyl, 1-methylethyl, methoxy, cyano ortrifluoromethyl.

Especially preferred compounds I are those where R³ is methyl.

Furthermore, preferred compounds I are those where R³ is methoxy.

Moreover, preferred compounds I are those where R³ is cyano.

Furthermore, preferred compounds I are those where R³ istrifluoromethyl.

Furthermore, preferred compounds I are those where n is 1.

Moreover, preferred compounds I are those where R⁴ is —(C═O)—R^(a).

Furthermore, preferred compounds I are those where R⁴ isC₁-C₄-alkylcarbonyl.

Moreover, preferred compounds I are those where R⁴ is—C(═NOR^(a))—A_(p)—R^(b).

Furthermore, preferred compounds I are those where R⁴ is—C(═NOR^(a))—R^(b).

Moreover, preferred compounds I are those where R⁴ isNR^(c)—(C═O)—A_(p)—R^(a).

Moreover, preferred compounds I are those where R⁴ is—O—(C═O)—NR^(a)R^(b).

Furthermore, preferred compounds I are those where R⁴ isN(R^(c))—OR^(d).

Furthermore, preferred compounds I are those where R^(a) or R^(b) isC₁-C₆-alkyl or C₂-C₆-alkenyl.

Furthermore, preferred compounds I are those where R⁴ isC₁-C₄-alkylenedioxy, the alkylene groups being partially or fullyhalogenated, preferably fluorinated.

Especially preferred compounds I are those where R⁴ isdifluoromethylenedioxy.

Moreover, preferred compounds I are those where R⁵ is hydrogen,C₃-C₆-cycloalkyl, arylalkyl, hetarylalkyl, aryloxyalkyl,hetaryloxyalkyl.

Especially preferred compounds I are those where R⁵ is C₁-C₆-alkyl.

Very especially preferred compounds I are those where R⁵ is methyl orethyl.

Furthermore, preferred compounds I are those where R⁵ isC₁-C₆-alkylsulfonyl.

Besides, preferred compounds of the formula I are those where X isNOCH₃.

Besides, preferred compounds of the formula I are those where X isCHOCH₃ and Y is O.

Besides, preferred compounds of the formula I are those where X is CHCH₃and Y is O.

Moreover, preferred compounds of the formula I are those where Y is O.

Furthermore, preferred compounds of the formula I are those where Y isNH or N—CH₃.

Especially preferred compounds of the formula I are those where Y is NHand R¹ is methyl.

Especially preferred compounds of the formula I are those where Y is Oand R¹ is methyl.

Compounds I which are particularly preferred with a view to their useare those compiled in the tables which follow.

The tables which follow (1 to 596) are based on the formulae I.1, I.2,I.3 and 1.4, the double bonds marked “E” having the E configuration:

TABLE 1 Compounds of the formula I.1 where R³ = hydrogen; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 2 Compounds of the formula I.2 where R³ = hydrogen; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 3 Compounds of the formula I.3 where R³ = hydrogen; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 4 Compounds of the formula I.4 where R³ = hydrogen; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 5 Compounds of the formula I.1 where R³ = hydrogen; R⁵ = methyl;R⁴ = in each case one line of Table A.

TABLE 6 Compounds of the formula I.2 where R³ = hydrogen; R⁵ = methyl;R⁴ = in each case one line of Table A.

TABLE 7 Compounds of the formula I.3 where R³ = hydrogen; R⁵ = methyl;R⁴ = in each case one line of Table A.

TABLE 8 Compounds of the formula I.4 where R³ = hydrogen; R⁵ = methyl;R⁴ = in each case one line of Table A.

TABLE 9 Compounds of the formula I.1 where R³ = hydrogen; R⁵ = ethyl; R⁴= in each case one line of Table A.

TABLE 10 Compounds of the formula I.2 where R³ = hydrogen; R⁵ = ethyl;R⁴ = in each case one line of Table A.

TABLE 11 Compounds of the formula I.3 where R³ = hydrogen; R⁵ = ethyl;R⁴ = in each case one line of Table A.

TABLE 12 Compounds of the formula I.4 where R³ = hydrogen; R⁵ = ethyl;R⁴ = in each case one line of Table A.

TABLE 13 Compounds of the formula I.1 where R³ = hydrogen; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 14 Compounds of the formula I.2 where R³ = hydrogen; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 15 Compounds of the formula I.3 where R³ = hydrogen; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 16 Compounds of the formula I.4 where R³ = hydrogen; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 17 Compounds of the formula I.1 where R³ = hydrogen; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 18 Compounds of the formula I.2 where R³ = hydrogen; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 19 Compounds of the formula I.3 where R³ = hydrogen; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 20 Compounds of the formula I.4 where R³ = hydrogen; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 21 Compounds of the formula I.1 where R³ = hydrogen; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 22 Compounds of the formula I.2 where R³ = hydrogen; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 23 Compounds of the formula I.3 where R³ = hydrogen; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 24 Compounds of the formula I.4 where R³ = hydrogen; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 25 Compounds of the formula I.1 where R³ = hydrogen; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 26 Compounds of the formula I.2 where R³ = hydrogen; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 27 Compounds of the formula I.3 where R³ = hydrogen; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 28 Compounds of the formula I.4 where R³ = hydrogen; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 29 Compounds of the formula I.1 where R³ = hydrogen; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 30 Compounds of the formula I.2 where R³ = hydrogen; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 31 Compounds of the formula I.3 where R³ = hydrogen; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 32 Compounds of the formula I.4 where R³ = hydrogen; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 33 Compounds of the formula I.1 where R³ = hydrogen; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 34 Compounds of the formula I.2 where R³ = hydrogen; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 35 Compounds of the formula I.3 where R³ = hydrogen; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 36 Compounds of the formula I.4 where R³ = hydrogen; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 37 Compounds of the formula I.1 where R³ = hydrogen; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 38 Compounds of the formula I.2 where R³ = hydrogen; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 39 Compounds of the formula I.3 where R³ = hydrogen; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 40 Compounds of the formula I.4 where R³ = hydrogen; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 41 Compound of the formula I.1 where R³ = hydrogen; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 42 Compounds of the formula I.2 where R³ = hydrogen; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 43 Compounds of the formula I.3 where R³ = hydrogen; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 44 Compounds of the formula I.4 where R³ = hydrogen; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 45 Compounds of the formula I.1 where R³ = hydrogen; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 46 Compounds of the formula I.2 where R³ = hydrogen; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 47 Compounds of the formula I.3 where R³ = hydrogen; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 48 Compounds of the formula I.4 where R³ = hydrogen; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 49 Compounds of the formula I.1 where R³ = hydrogen; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 50 Compounds of the formula I.2 where R³ = hydrogen; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 51 Compounds of the formula I.3 where R³ = hydrogen; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 52 Compounds of the formula I.4 where R³ = hydrogen; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 53 Compounds of the formula I.1 where R³ = hydrogen; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 54 Compounds of the formula I.2 where R³ = hydrogen; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 55 Compounds of the formula I.3 where R³ = hydrogen; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 56 Compounds of the formula I.4 where R³ = hydrogen; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 57 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =hydrogen; R⁴ = in each case one line of Table A.

TABLE 58 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =hydrogen; R⁴ = in each case one line of Table A.

TABLE 59 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =hydrogen; R⁴ = in each case one line of Table A.

TABLE 60 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =hydrogen; R⁴ = in each case one line of Table A.

TABLE 61 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =methyl; R⁴ = in each case one line of Table A.

TABLE 62 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =methyl; R⁴ = in each case one line of Table A.

TABLE 63 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =methyl; R⁴ = in each case one line of Table A.

TABLE 64 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =methyl; R⁴ = in each case one line of Table A.

TABLE 65 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =ethyl; R⁴ = in each case one line of Table A.

TABLE 66 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =ethyl; R⁴ = in each case one line of Table A.

TABLE 67 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =ethyl; R⁴ = in each case one line of Table A.

TABLE 68 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =ethyl; R⁴ = in each case one line of Table A.

TABLE 69 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 70 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 71 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 72 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 73 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 74 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 75 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 76 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 77 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 78 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 79 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 80 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 81 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =n-butyl; R⁴ = in each case one line of Table A.

TABLE 82 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =n-butyl; R⁴ = in each case one line of Table A.

TABLE 83 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =n-butyl; R⁴ = in each case one line of Table A.

TABLE 84 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =n-butyl; R⁴ = in each case one line of Table A.

TABLE 85 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 86 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 87 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 88 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 89 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 90 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 91 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 92 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 93 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 94 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 95 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 96 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 97 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 98 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 99 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 100 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 101 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 102 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 103 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 104 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 105 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 106 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 107 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 108 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 109 Compounds of the formula I.1 where R³ = cyclopropyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 110 Compounds of the formula I.2 where R³ = cyclopropyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 111 Compounds of the formula I.3 where R³ = cyclopropyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 112 Compounds of the formula I.4 where R³ = cyclopropyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 113 Compounds of the formula I.1 where R³ = ethyl; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 114 Compounds of the formula I.2 where R³ = ethyl; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 115 Compounds of the formula I.3 where R³ = ethyl; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 116 Compounds of the formula I.4 where R³ = ethyl; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 117 Compounds of the formula I.1 where R³ = ethyl; R⁵ = methyl; R⁴= in each case one line of Table A.

TABLE 118 Compounds of the formula I.2 where R³ = ethyl; R⁵ = methyl; R⁴= in each case one line of Table A.

TABLE 119 Compounds of the formula I.3 where R³ = ethyl; R⁵ = methyl; R⁴= in each case one line of Table A.

TABLE 120 Compounds of the formula I.4 where R³ = ethyl; R⁵ = methyl; R⁴= in each case one line of Table A.

TABLE 121 Compounds of the formula I.1 where R³ = ethyl; R⁵ = ethyl; R⁴= in each case one line of Table A.

TABLE 122 Compounds of the formula I.2 where R³ = ethyl; R⁵ = ethyl; R⁴= in each case one line of Table A.

TABLE 123 Compounds of the formula I.3 where R³ = ethyl; R⁵ = ethyl; R⁴= in each case one line of Table A.

TABLE 124 Compounds of the formula I.4 where R³ = ethyl; R⁵ = ethyl; R⁴= in each case one line of Table A.

TABLE 125 Compounds of the formula I.1 where R³ = ethyl; R⁵ = n-propyl;R⁴ = in each case one line of Table A.

TABLE 126 Compounds of the formula I.2 where R³ = ethyl; R⁵ = n-propyl;R⁴ = in each case one line of Table A.

TABLE 127 Compounds of the formula I.3 where R³ = ethyl; R⁵ = n-propyl;R⁴ = in each case one line of Table A.

TABLE 128 Compounds of the formula I.4 where R³ = ethyl; R⁵ = n-propyl;R⁴ = in each case one line of Table A.

TABLE 129 Compounds of the formula I.1 where R³ = ethyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 130 Compounds of the formula I.2 where R³ = ethyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 131 Compounds of the formula I.3 where R³ = ethyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 132 Compounds of the formula I.4 where R³ = ethyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 133 Compounds of the formula I.1 where R³ = ethyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 134 Compounds of the formula I.2 where R³ = ethyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 135 Compounds of the formula I.3 where R³ = ethyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 136 Compounds of the formula I.4 where R³ = ethyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 137 Compounds of the formula I.1 where R³ = ethyl; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 138 Compounds of the formula I.2 where R³ = ethyl; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 139 Compounds of the formula I.3 where R³ = ethyl; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 140 Compounds of the formula I.4 where R³ = ethyl; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 141 Compounds of the formula I.1 where R³ = ethyl; R⁵ =2-methoxyeth-1-yl; R⁴= in each case one line of Table A.

TABLE 142 Compoundss of the formula I.2 where R³ = ethyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 143 Compounds of the formula I.3 where R³ = ethyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 144 Compounds of the formula I.4 where R³ = ethyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 145 Compounds of the formula I.1 where R³ = ethyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 146 Compounds of the formula I.2 where R³ = ethyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 147 Compounds of the formula I.3 where R³ = ethyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 148 Compounds of the formula I.4 where R³ = ethyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 149 Compounds of the formula I.1 where R³ = ethyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 150 Compounds of the formula I.2 where R³ = ethyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 151 Compounds of the formula I.3 where R³ = ethyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 152 Compounds of the formula I.4 where R³ = ethyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 153 Compounds of the formula I.1 where R³ = ethyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 154 Compounds of the formula I.2 where R³ = ethyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 155 Compounds of the formula I.3 where R³ = ethyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 156 Compounds of the formula I.4 where R³ = ethyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 157 Compounds of the formula I.1 where R³ = ethyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 158 Compounds of the formula I.2 where R³ = ethyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 159 Compounds of the formula I.3 where R³ = ethyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 160 Compounds of the formula I.4 where R³ = ethyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 161 Compounds of the formula I.1 where R³ = ethyl; R⁵ =Z-3-chloroprop-2-en-1-yl, R⁴ = in each case one line of Table A.

TABLE 162 Compounds of the formula I.2 where R³ = ethyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 163 Compounds of the formula I.3 where R³ = ethyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 164 Compounds of the formula I.4 where R³ = ethyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 165 Compounds of the formula I.1 where R³ = ethyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 166 Compounds of the formula I.2 where R³ = ethyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 167 Compounds of the formula I.3 where R³ = ethyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 168 Compounds of the formula I.4 where R³ = ethyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 169 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =hydrogen; R⁴ = in each case one line of Table A.

TABLE 170 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =hydrogen; R⁴ = in each case one line of Table A.

TABLE 171 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =hydrogen; R⁴ = in each case one line of Table A.

TABLE 172 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =hydrogen; R⁴ = in each case one line of Table A.

TABLE 173 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =methyl; R⁴ = in each case one line of Table A.

TABLE 174 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =methyl; R⁴ = in each case one line of Table A.

TABLE 175 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =methyl; R⁴ = in each case one line of Table A.

TABLE 176 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =methyl; R⁴ = in each case one line of Table A.

TABLE 177 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =ethyl; R⁴ = in each case one line of Table A.

TABLE 178 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =ethyl; R⁴ = in each case one line of Table A.

TABLE 179 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =ethyl; R⁴ = in each case one line of Table A.

TABLE 180 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =ethyl; R⁴ = in each case one line of Table A.

TABLE 181 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 182 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 183 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 184 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =n-propyl; R⁴ = in each case one line of Table A.

TABLE 185 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 186 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 187 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 188 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 189 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 190 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 191 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 192 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 193 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =n-butyl; R⁴ = in each case one line of Table A.

TABLE 194 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =n-butyl; R⁴ = in each case one line of Table A.

TABLE 195 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =n-butyl; R⁴ = in each case one line of Table A.

TABLE 196 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =n-butyl; R⁴ = in each case one line of Table A.

TABLE 197 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 198 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 199 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 200 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 201 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 202 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 203 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 204 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 205 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 206 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 207 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 208 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 209 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 210 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 211 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 212 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 213 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 214 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 215 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 216 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 217 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 218 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 219 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 220 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 221 Compounds of the formula I.1 where R³ = trifluoromethyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 222 Compounds of the formula I.2 where R³ = trifluoromethyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 223 Compounds of the formula I.3 where R³ = trifluoromethyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 224 Compounds of the formula I.4 where R³ = trifluoromethyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 225 Compounds of the formula I.1 where R³ = methyl; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 226 Compounds of the formula I.2 where R³ = methyl; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 227 Compounds of the formula I.3 where R³ = methyl; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 228 Compounds of the formula I.4 where R³ = methyl; R⁵ = hydrogen;R⁴ = in each case one line of Table A.

TABLE 229 Compounds of the formula I.1 where R³ = methyl; R⁵ = methyl;R⁴ = in each case one line of Table A.

TABLE 230 Compounds of the formula I.2 where R³ = methyl; R⁵ = methyl;R⁴ = in each case one line of Table A.

TABLE 231 Compounds of the formula I.3 where R³ = methyl; R⁵ = methyl;R⁴ = in each case one line of Table A.

TABLE 232 Compounds of the formula I.4 where R³ = methyl; R⁵ = methyl;R⁴ = in each case one line of Table A.

TABLE 233 Compounds of the formula I.1 where R³ = methyl; R⁵ = ethyl; R⁴= in each case one line of Table A.

TABLE 234 Compounds of the formula I.2 where R³ = methyl; R⁵ = ethyl; R⁴= in each case one line of Table A.

TABLE 235 Compounds of the formula I.3 where R³ = methyl; R⁵ = ethyl; R⁴= in each case one line of Table A.

TABLE 236 Compounds of the formula I.4 where R³ = methyl; R⁵ = ethyl; R⁴= in each case one line of Table A.

TABLE 237 Compounds of the formula I.1 where R³ = methyl; R⁵ = n-propyl;R⁴ = in each case one line of Table A.

TABLE 238 Compounds of the formula I.2 where R³ = methyl; R⁵ = n-propyl;R⁴ = in each case one line of Table A.

TABLE 239 Compounds of the formula I.3 where R³ = methyl; R⁵ = n-propyl;R⁴ = in each case one line of Table A.

TABLE 240 Compounds of the formula I.4 where R³ = methyl; R⁵ = n-propyl;R⁴ = in each case one line of Table A.

TABLE 241 Compounds of the formula I.1 where R³ = methyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 242 Compounds of the formula I.2 where R³ = methyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 243 Compounds of the formula I.3 where R³ = methyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 244 Compounds of the formula I.4 where R³ = methyl; R⁵ =iso-propyl; R⁴ = in each case one line of Table A.

TABLE 245 Compounds of the formula I.1 where R³ = methyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 246 Compounds of the formula I.2 where R³ = methyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 247 Compounds of the formula I.3 where R³ = methyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 248 Compounds of the formula I.4 where R³ = methyl; R⁵ =cyclopropyl; R⁴ = in each case one line of Table A.

TABLE 249 Compounds of the formula I.1 where R³ = methyl; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 250 Compounds of the formula I.2 where R³ = methyl; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 251 Compounds of the formula I.3 where R³ = methyl; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 252 Compounds of the formula I.4 where R³ = methyl; R⁵ = n-butyl;R⁴ = in each case one line of Table A.

TABLE 253 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 254 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 255 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 256 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-methoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 257 Compounds of the formula I.1 where R³ = methyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 258 Compounds of the formula I.2 where R³ = methyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 259 Compounds of the formula I.3 where R³ = methyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 260 Compounds of the formula I.4 where R³ = methyl; R⁵ =prop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 261 Compounds of the formula I.1 where R³ = methyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 262 Compounds of the formula I.2 where R³ = methyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 263 Compounds of the formula I.3 where R³ = methyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 264 Compounds of the formula I.4 where R³ = methyl; R⁵ =E-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 265 Compounds of the formula I.1 where R³ = methyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 266 Compounds of the formula I.2 where R³ = methyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 267 Compounds of the formula I.3 where R³ = methyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 268 Compounds of the formula I.4 where R³ = methyl; R⁵ =Z-but-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 269 Compounds of the formula I.1 where R³ = methyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 270 Compounds of the formula I.2 where R³ = methyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 271 Compounds of the formula I.3 where R³ = methyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 272 Compounds of the formula I.4 where R³ = methyl; R⁵ =E-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 273 Compounds of the formula I.1 where R³ = methyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 274 Compounds of the formula I.2 where R³ = methyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 275 Compounds of the formula I.3 where R³ = methyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 276 Compounds of the formula I.4 where R³ = methyl; R⁵ =Z-3-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 277 Compounds of the formula I.1 where R³ = methyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 278 Compounds of the formula I.2 where R³ = methyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 279 Compounds of the formula I.3 where R³ = methyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 280 Compounds of the formula I.4 where R³ = methyl; R⁵ =prop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 281 Compounds of the formula I.1 where R³ = methyl; R⁵ = 2-butyl;R⁴ = in each case one line of Table A.

TABLE 282 Compounds of the formula I.2 where R³ = methyl; R⁵ = 2-butyl;R⁴ = in each case one line of Table A.

TABLE 283 Compounds of the formula I.3 where R³ = methyl; R⁵ = 2-butyl;R⁴ = in each case one line of Table A.

TABLE 284 Compounds of the formula I.4 where R³ = methyl; R⁵ = 2-butyl;R⁴ = in each case one line of Table A.

TABLE 285 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-methylprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 286 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-methylprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 287 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-methylprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 288 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-methylprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 289 Compounds of the formula I.1 where R³ = methyl; R⁵ =1,1-dimethyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 290 Compounds of the formula I.2 where R³ = methyl; R⁵ =1,1-dimethyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 291 Compounds of the formula I.3 where R³ = methyl; R⁵ =1,1-dimethyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 292 Compounds of the formula I.4 where R³ = methyl; R⁵ =1,1-dimethyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 293 Compounds of the formula I.1 where R³ = methyl; R⁵ = 1-pentyl;R⁴ = in each case one line of Table A.

TABLE 294 Compounds of the formula I.2 where R³ = methyl; R⁵ = 1-pentyl;R⁴ = in each case one line of Table A.

TABLE 295 Compounds of the formula I.3 where R³ = methyl; R⁵ = 1-pentyl;R⁴ = in each case one line of Table A.

TABLE 296 Compounds of the formula I.4 where R³ = methyl; R⁵ = 1-pentyl;R⁴ = in each case one line of Table A.

TABLE 297 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 298 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 299 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 300 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 301 Compounds of the formula I.1 where R³ = methyl; R⁵ =2,2-dimethylprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 302 Compounds of the formula I.2 where R³ = methyl; R⁵ =2,2-dimethylprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 303 Compounds of the formula I.3 where R³ = methyl; R⁵ =2,2-dimethylprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 304 Compounds of the formula I.4 where R³ = methyl; R⁵ =2,2-dimethylprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 305 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 306 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 307 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 308 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 309 Compounds of the formula I.1 where R³ = methyl; R⁵ =1-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 310 Compounds of the formula I.2 where R³ = methyl; R⁵ =1-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 311 Compounds of the formula I.3 where R³ = methyl; R⁵ =1-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 312 Compounds of the formula I.4 where R³ = methyl; R⁵ =1-methylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 313 Compounds of the formula I.1 where R³ = methyl; R⁵ = 3-pentyl;R⁴ = in each case one line of Table A.

TABLE 314 Compounds of the formula I.2 where R³ = methyl; R⁵ = 3-pentyl;R⁴ = in each case one line of Table A.

TABLE 315 Compounds of the formula I.3 where R³ = methyl; R⁵ = 3-pentyl;R⁴ = in each case one line of Table A.

TABLE 316 Compounds of the formula I.4 where R³ = methyl; R⁵ = 3-pentyl;R⁴ = in each case one line of Table A.

TABLE 317 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-methylbut-2-yl; R⁴ = in each case one line of Table A.

TABLE 318 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-methylbut-2-yl; R⁴ = in each case one line of Table A.

TABLE 319 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-methylbut-2-yl; R⁴ = in each case one line of Table A.

TABLE 320 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-methylbut-2-yl; R⁴ = in each case one line of Table A.

TABLE 321 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-methylbut-2-yl; R⁴ = in each case one line of Table A.

TABLE 322 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-methylbut-2-yl; R⁴ = in each case one line of Table A.

TABLE 323 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-methylbut-2-yl; R⁴ = in each case one line of Table A.

TABLE 324 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-methylbut-2-yl; R⁴ = in each case one line of Table A.

TABLE 325 Compounds of the formula I.1 where R³ = methyl; R⁵ = 1-hexyl;R⁴ = in each case one line of Table A.

TABLE 326 Compounds of the formula I.2 where R³ = methyl; R⁵ = 1-hexyl;R⁴ = in each case one line of Table A.

TABLE 327 Compounds of the formula I.3 where R³ = methyl; R⁵ = 1-hexyl;R⁴ = in each case one line of Table A.

TABLE 328 Compounds of the formula I.4 where R³ = methyl; R⁵ = 1-hexyl;R⁴ = in each case one line of Table A.

TABLE 329 Compounds of the formula I.1 where R³ = methyl; R⁵ =3,3-dimethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 330 Compounds of the formula I.2 where R³ = methyl; R⁵ =3,3-dimethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 331 Compounds of the formula I.3 where R³ = methyl; R⁵ =3,3-dimethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 332 Compounds of the formula I.4 where R³ = methyl; R⁵ =3,3-dimethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 333 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-ethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 334 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-ethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 335 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-ethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 336 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-ethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 337 Compounds of the formula I.1 where R³ = methyl; R⁵ =1-ethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 338 Compounds of the formula I.2 where R³ = methyl; R⁵ =1-ethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 339 Compounds of the formula I.3 where R³ = methyl; R⁵ =1-ethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 340 Compounds of the formula I.4 where R³ = methyl; R⁵ =1-ethylbut-1-yl; R⁴ = in each case one line of Table A.

TABLE 341 Compounds of the formula I.1 where R³ = methyl; R⁵ =4-methylpent-1-yl; R⁴ = in each case one line of Table A.

TABLE 342 Compounds of the formula I.2 where R³ = methyl; R⁵ =4-methylpent-1-yl; R⁴ = in each case one line of Table A.

TABLE 343 Compounds of the formula I.3 where R³ = methyl; R⁵ =4-methylpent-1-yl; R⁴ = in each case one line of Table A.

TABLE 344 Compounds of the formula I.4 where R³ = methyl; R⁵ =4-methylpent-1-yl; R⁴ = in each case one line of Table A.

TABLE 345 Compounds of the formula I.1 where R³ = methyl; R⁵ =cyclopropylmethyl; R⁴ = in each case one line of Table A.

TABLE 346 Compounds of the formula I.2 where R³ = methyl; R⁵ =cyclopropylmethyl; R⁴ = in each case one line of Table A.

TABLE 347 Compounds of the formula I.3 where R³ = methyl; R⁵ =cyclopropylmethyl; R⁴ = in each case one line of Table A.

TABLE 348 Compounds of the formula I.4 where R³ = methyl; R⁵ =cyclopropylmethyl; R⁴ = in each case one line of Table A.

TABLE 349 Compounds of the formula I.1 where R³ = methyl; R⁵ =cyclopentylmethyl; R⁴ = in each case one line of Table A.

TABLE 350 Compounds of the formula I.2 where R³ = methyl; R⁵ =cyclopentylmethyl; R⁴ = in each case one line of Table A.

TABLE 351 Compounds of the formula I.3 where R³ = methyl; R⁵ =cyclopentylmethyl; R⁴ = in each case one line of Table A.

TABLE 352 Compounds of the formula I.4 where R³ = methyl; R⁵ =cyclopentylmethyl; R⁴ = in each case one line of Table A.

TABLE 353 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-cyclopropyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 354 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-cyclopropyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 355 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-cyclopropyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 356 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-cyclopropyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 357 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-cyclopentyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 358 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-cyclopentyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 359 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-cyclopentyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 360 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-cyclopentyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 361 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-cyclohexyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 362 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-cyclohexyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 363 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-cyclohexyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 364 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-cyclohexyleth-1-yl; R⁴ = in each case one line of Table A.

TABLE 365 Compounds of the formula I.1 where R³ = methyl; R⁵ =fluoromethyl; R⁴ = in each case one line of Table A.

TABLE 366 Compounds of the formula I.2 where R³ = methyl; R⁵ =fluoromethyl; R⁴ = in each case one line of Table A.

TABLE 367 Compounds of the formula I.3 where R³ = methyl; R⁵ =fluoromethyl; R⁴ = in each case one line of Table A.

TABLE 368 Compounds of the formula I.4 where R³ = methyl; R⁵ =fluoromethyl; R⁴ = in each case one line of Table A.

TABLE 369 Compounds of the formula I.1 where R³ = methyl; R⁵ =difluoromethyl; R⁴ = in each case one line of Table A.

TABLE 370 Compounds of the formula I.2 where R³ = methyl; R⁵ =difluoromethyl; R⁴ = in each case one line of Table A.

TABLE 371 Compounds of the formula I.3 where R³ = methyl; R⁵ =difluoromethyl; R⁴ = in each case one line of Table A.

TABLE 372 Compounds of the formula I.4 where R³ = methyl; R⁵ =difluoromethyl; R⁴ = in each case one line of Table A.

TABLE 373 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-fluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 374 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-fluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 375 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-fluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 376 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-fluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 377 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-fluoroprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 378 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-fluoroprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 379 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-fluoroprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 380 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-fluoroprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 381 Compounds of the formula I.1 where R³ = methyl; R⁵ =2,2-difluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 382 Compounds of the formula I.2 where R³ = methyl; R⁵ =2,2-difluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 383 Compounds of the formula I.3 where R³ = methyl; R⁵ =2,2-difluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 384 Compounds of the formula I.4 where R³ = methyl; R⁵ =2,2-difluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 385 Compounds of the formula I.1 where R³ = methyl; R⁵ =2,2,2-trifluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 386 Compounds of the formula I.2 where R³ = methyl; R⁵ =2,2,2-trifluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 387 Compounds of the formula I.3 where R³ = methyl; R⁵ =2,2,2-trifluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 388 Compounds of the formula I.4 where R³ = methyl; R⁵ =2,2,2-trifluoroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 389 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-bromoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 390 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-bromoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 391 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-bromoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 392 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-bromoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 393 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-bromoprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 394 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-bromoprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 395 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-bromoprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 396 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-bromoprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 397 Compounds of the formula I.1 where R³ = methyl; R⁵ =4-bromobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 398 Compounds of the formula I.2 where R³ = methyl; R⁵ =4-bromobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 399 Compounds of the formula I.3 where R³ = methyl; R⁵ =4-bromobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 400 Compounds of the formula I.4 where R³ = methyl; R⁵ =4-bromobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 401 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-iodoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 402 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-iodoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 403 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-iodoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 404 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-iodoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 405 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-chloroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 406 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-chloroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 407 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-chloroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 408 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-chloroeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 409 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-chloroprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 410 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-chloroprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 411 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-chloroprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 412 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-chloroprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 413 Compounds of the formula I.1 where R³ = methyl; R⁵ =4-chlorobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 414 Compounds of the formula I.2 where R³ = methyl; R⁵ =4-chlorobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 415 Compounds of the formula I.3 where R³ = methyl; R⁵ =4-chlorobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 416 Compounds of the formula I.4 where R³ = methyl; R⁵ =4-chlorobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 417 Compounds of the formula I.1 where R³ = methyl; R⁵ =cyanomethyl; R⁴ = in each case one line of Table A.

TABLE 418 Compounds of the formula I.2 where R³ = methyl; R⁵ =cyanomethyl; R⁴ = in each case one line of Table A.

TABLE 419 Compounds of the formula I.3 where R³ = methyl; R⁵ =cyanomethyl; R⁴ = in each case one line of Table A.

TABLE 420 Compounds of the formula I.4 where R³ = methyl; R⁵ =cyanomethyl; R⁴ = in each case one line of Table A.

TABLE 421 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-cyanoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 422 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-cyanoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 423 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-cyanoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 424 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-cyanoeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 425 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-cyanoprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 426 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-cyanoprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 427 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-cyanoprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 428 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-cyanoprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 429 Compounds of the formula I.1 where R³ = methyl; R⁵ =4-cyanobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 430 Compounds of the formula I.2 where R³ = methyl; R⁵ =4-cyanobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 431 Compounds of the formula I.3 where R³ = methyl; R⁵ =4-cyanobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 432 Compounds of the formula I.4 where R³ = methyl; R⁵ =4-cyanobut-1-yl; R⁴ = in each case one line of Table A.

TABLE 433 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-ethoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 434 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-ethoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 435 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-ethoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 436 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-ethoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 437 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-isopropoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 438 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-isopropoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 439 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-isopropoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 440 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-isopropoxyeth-1-yl; R⁴ = in each case one line of Table A.

TABLE 441 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-methoxyprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 442 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-methoxyprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 443 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-methoxyprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 444 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-methoxyprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 445 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-ethoxyprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 446 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-ethoxyprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 447 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-ethoxyprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 448 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-ethoxyprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 449 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-isopropoxyprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 450 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-isopropoxyprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 451 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-isopropoxyprop-1-yl; R⁴ = in each case one line of Table A.

TABLE 452 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-isopropoxypro#-1-yl; R⁴ = in each case one line of Table A.

TABLE 453 Compounds of the formula I.1 where R³ = methyl; R⁵ =4-methoxybut-1-yl; R⁴ = in each case one line of Table A.

TABLE 454 Compounds of the formula I.2 where R³ = methyl; R⁵ =4-methoxybut-1-yl; R⁴ = in each case one line of Table A.

TABLE 455 Compounds of the formula I.3 where R³ = methyl; R⁵ =4-methoxybut-1-y1; R⁴ = in each case one line of Table A.

TABLE 456 Compounds of the formula I.4 where R³ = methyl; R⁵ =4-methoxybut-1-yl; R⁴ = in each case one line of Table A.

TABLE 457 Compounds of the formula I.1 where R³ = methyl; R⁵ =4-ethoxybut-1-yl; R⁴ = in each case one line of Table A.

TABLE 458 Compounds of the formula I.2 where R³ = methyl; R⁵ =4-ethoxybut-1-yl; R⁴ = in each case one line of Table A.

TABLE 459 Compounds of the formula I.3 where R³ = methyl; R⁵ =4-ethoxybut-1-yl; R⁴ = in each case one line of Table A.

TABLE 460 Compounds of the formula I.4 where R³ = methyl; R⁵ =4-ethoxybut-1-yl; R⁴ = in each case one line of Table A.

TABLE 461 Compounds of the formula I.1 where R³ = methyl; R⁵ =4-isopropoxybut-1-yl; R⁴ = in each case one line of Table A.

TABLE 462 Compounds of the formula I.2 where R³ = methyl; R⁵ =4-isopropoxybut-1-yl; R⁴ = in each case one line of Table A.

TABLE 463 Compounds of the formula I.3 where R³ = methyl; R⁵ =4-isopropoxybut-1-yl; R⁴ = in each case one line of Table A.

TABLE 464 Compounds of the formula I.4 where R³ = methyl; R⁵ =4-isopropoxybut-1-yl; R⁴ = in each case one line of Table A.

TABLE 465 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-methylbut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 466 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-methylbut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 467 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-methylbut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 468 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-methylbut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 469 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-methylprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 470 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-methylprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 471 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-methylprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 472 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-methylprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 473 Compounds of the formula I.1 where R³ = methyl; R⁵ =but-3-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 474 Compounds of the formula I.2 where R³ = methyl; R⁵ =but-3-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 475 Compounds of the formula I.3 where R³ = methyl; R⁵ =but-3-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 476 Compounds of the formula I.4 where R³ = methyl; R⁵ =but-3-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 477 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 478 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 479 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 480 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-chloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 481 Compounds of the formula I.1 where R³ = methyl; R⁵ =3,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 482 Compounds of the formula I.2 where R³ = methyl; R⁵ =3,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 483 Compounds of the formula I.3 where R³ = methyl; R⁵ =3,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 484 Compounds of the formula I.4 where R³ = methyl; R⁵ =3,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 485 Compounds of the formula I.1 where R³ = methyl; R⁵ =2,3,3-trichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 486 Compounds of the formula I.2 where R³ = methyl; R⁵ =2,3,3-trichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 487 Compounds of the formula I.3 where R³ = methyl; R⁵ =2,3,3-trichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 488 Compounds of the formula I.4 where R³ = methyl; R⁵ =2,3,3-trichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 489 Compounds of the formula I.1 where R³ = methyl; R⁵ =Z-2,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 490 Compounds of the formula I.2 where R³ = methyl; R⁵ =Z-2,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 491 Compounds of the formula I.3 where R³ = methyl; R⁵ =Z-2,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 492 Compounds of the formula I.4 where R³ = methyl; R⁵ =Z-2,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 493 Compounds of the formula I.1 where R³ = methyl; R⁵ =E-2,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 494 Compounds of the formula I.2 where R³ = methyl; R⁵ =E-2,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 495 Compounds of the formula I.3 where R³ = methyl; R⁵ =E-2,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 496 Compounds of the formula I.4 where R³ = methyl; R⁵ =E-2,3-dichloroprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 497 Compounds of the formula I.1 where R³ = methyl; R⁵ =Z-3-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 498 Compounds of the formula I.2 where R³ = methyl; R⁵ =Z-3-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 499 Compounds of the formula I.3 where R³ = methyl; R⁵ =Z-3-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 500 Compounds of the formula I.4 where R³ = methyl; R⁵ =Z-3-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 501 Compounds of the formula I.1 where R³ = methyl; R⁵ =E-3-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 502 Compounds of the formula I.2 where R³ = methyl; R⁵ =E-3-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 503 Compounds of the formula I.3 where R³ = methyl; R⁵ =E-3-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 504 Compounds of the formula I.4 where R³ = methyl; R⁵ =E-3-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 505 Compounds of the formula I.1 where R³ = methyl; R⁵ =2-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 506 Compounds of the formula I.2 where R³ = methyl; R⁵ =2-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 507 Compounds of the formula I.3 where R³ = methyl; R⁵ =2-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 508 Compounds of the formula I.4 where R³ = methyl; R⁵ =2-bromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 509 Compounds of the formula I.1 where R³ = methyl; R⁵ =3,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 510 Compounds of the formula I.2 where R³ = methyl; R⁵ =3,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 511 Compounds of the formula I.3 where R³ = methyl; R⁵ =3,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 512 Compounds of the formula I.4 where R³ = methyl; R⁵ =3,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 513 Compounds of the formula I.1 where R³ = methyl; R⁵ =2,3,3-tribromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 514 Compounds of the formula I.2 where R³ = methyl; R⁵ =2,3,3-tribromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 515 Compounds of the formula I.3 where R³ = methyl; R⁵ =2,3,3-tribromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 516 Compounds of the formula I.4 where R³ = methyl; R⁵ =2,3,3-tribromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 517 Compounds of the formula I.1 where R³ = methyl; R⁵ =Z-2,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 518 Compounds of the formula I.2 where R³ = methyl; R⁵ =Z-2,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 519 Compounds of the formula I.3 where R³ = methyl; R⁵ =Z-2,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 520 Compounds of the formula I.4 where R³ = methyl; R⁵ =Z-2,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 521 Compounds of the formula I.1 where R³ = methyl; R⁵ =E-2,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 522 Compounds of the formula I.2 where R³ = methyl; R⁵ =E-2,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 523 Compounds of the formula I.3 where R³ = methyl; R⁵ =E-2,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 524 Compounds of the formula I.4 where R³ = methyl; R⁵ =E-2,3-dibromoprop-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 525 Compounds of the formula I.1 where R³ = methyl; R⁵ =E-2-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 526 Compounds of the formula I.2 where R³ = methyl; R⁵ =E-2-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 527 Compounds of the formula I.3 where R³ = methyl; R⁵ =E-2-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 528 Compounds of the formula I.4 where R³ = methyl; R⁵ =E-2-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 529 Compounds of the formula I.1 where R³ = methyl; R⁵ =Z-2-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 530 Compounds of the formula I.2 where R³ = methyl; R⁵ =Z-2-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 531 Compounds of the formula I.3 where R³ = methyl; R⁵ =Z-2-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 532 Compounds of the formula I.4 where R³ = methyl; R⁵ =Z-2-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 533 Compounds of the formula I.1 where R³ = methyl; R⁵ =E-3-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 534 Compounds of the formula I.2 where R³ = methyl; R⁵ =E-3-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 535 Compounds of the formula I.3 where R³ = methyl; R⁵ =E-3-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 536 Compounds of the formula I.4 where R³ = methyl; R⁵ =E-3-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 537 Compounds of the formula I.1 where R³ = methyl; R⁵ =Z-3-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 538 Compounds of the formula I.2 where R³ = methyl; R⁵ =Z-3-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 539 Compounds of the formula I.3 where R³ = methyl; R⁵ =Z-3-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 540 Compounds of the formula I.4 where R³ = methyl; R⁵ =Z-3-chlorobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 541 Compounds of the formula I.1 where R³ = methyl; R⁵ =E-2-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 542 Compounds of the formula I.2 where R³ = methyl; R⁵ =E-2-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 543 Compounds of the formula I.3 where R³ = methyl; R⁵ =E-2-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 544 Compounds of the formula I.4 where R³ = methyl; R⁵ =E-2-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 545 Compounds of the formula I.1 where R³ = methyl; R⁵ =Z-2-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 546 Compounds of the formula I.2 where R³ = methyl; R⁵ =Z-2-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 547 Compounds of the formula I.3 where R³ = methyl; R⁵ =Z-2-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 548 Compounds of the formula I.4 where R³ = methyl; R⁵ =Z-2-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 549 Compounds of the formula I.1 where R³ = methyl; R⁵ =E-3-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 550 Compounds of the formula I.2 where R³ = methyl; R⁵ =E-3-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 551 Compounds of the formula I.3 where R³ = methyl; R⁵ =E-3-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 552 Compounds of the formula I.4 where R³ = methyl; R⁵ =E-3-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 553 Compounds of the formula I.1 where R³ = methyl; R⁵ =Z-3-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 554 Compounds of the formula I.2 where R³ = methyl; R⁵ =Z-3-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 555 Compounds of the formula I.3 where R³ = methyl; R⁵ =Z-3-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 556 Compounds of the formula I.4 where R³ = methyl; R⁵ =Z-3-bromobut-2-en-1-yl; R⁴ = in each case one line of Table A.

TABLE 557 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-chloroprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 558 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-chloroprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 559 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-chloroprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 560 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-chloroprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 561 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-bromoprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 562 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-bromoprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 563 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-bromoprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 564 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-bromoprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 565 Compounds of the formula I.1 where R³ = methyl; R⁵ =3-iodoprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 566 Compounds of the formula I.2 where R³ = methyl; R⁵ =3-iodoprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 567 Compounds of the formula I.3 where R³ = methyl; R⁵ =3-iodoprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 568 Compounds of the formula I.4 where R³ = methyl; R⁵ =3-iodoprop-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 569 Compounds of the formula I.1 where R³ = methyl; R⁵ =but-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 570 Compounds of the formula I.2 where R³ = methyl; R⁵ =but-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 571 Compounds of the formula I.3 where R³ = methyl; R⁵ =but-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 572 Compounds of the formula I.4 where R³ = methyl; R⁵ =but-2-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 573 Compounds of the formula I.1 where R³ = methyl; R⁵ =but-3-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 574 Compounds of the formula I.2 where R³ = methyl; R⁵ =but-3-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 575 Compounds of the formula I.3 where R³ = methyl; R⁵ =but-3-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 576 Compounds of the formula I.4 where R³ = methyl; R⁵ =but-3-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 577 Compounds of the formula I.1 where R³ = methyl; R⁵ =but-3-yn-2-yl; R⁴ = in each case one line of Table A.

TABLE 578 Compounds of the formula I.2 where R³ = methyl; R⁵ =but-3-yn-2-yl; R⁴ = in each case one line of Table A.

TABLE 579 Compounds of the formula I.3 where R³ = methyl; R⁵ =but-3-yn-2-yl; R⁴ = in each case one line of Table A.

TABLE 580 Compounds of the formula I.4 where R³ = methyl; R⁵ =but-3-yn-2-yl; R⁴ = in each case one line of Table A.

TABLE 581 Compounds of the formula I.1 where R³ = methyl; R⁵ =pent-3-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 582 Compounds of the formula I.2 where R³ = methyl; R⁵ =pent-3-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 583 Compounds of the formula I.3 where R³ = methyl; R⁵ =pent-3-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 584 Compounds of the formula I.4 where R³ = methyl; R⁵ =pent-3-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 585 Compounds of the formula I.1 where R³ = methyl; R⁵ =pent-4-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 586 Compounds of the formula I.2 where R³ = methyl; R⁵ =pent-4-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 587 Compounds of the formula I.3 where R³ = methyl; R⁵ =pent-4-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 588 Compounds of the formula I.4 where R³ = methyl; R⁵ =pent-4-yn-1-yl; R⁴ = in each case one line of Table A.

TABLE 589 Compounds of the formula I.1 where R³ = methyl; R⁵ =pent-3-yn-2-yl; R⁴ = in each case one line of Table A.

TABLE 590 Compounds of the formula I.2 where R³ = methyl; R⁵ =pent-3-yn-2-yl; R⁴ = in each case one line of Table A.

TABLE 591 Compounds of the formula I.3 where R³ = methyl; R⁵ =pent-3-yn-2-yl; R⁴ = in each case one line of Table A.

TABLE 592 Compounds of the formula I.4 where R³ = methyl; R⁵ =pent-3-yn-2-yl; R⁴ = in each case one line of Table A.

TABLE 593 Compounds of the formula I.1 where R³ = methyl; R⁵ =cyclohexylmethyl; R⁴ = in each case one line of Table A.

TABLE 594 Compounds of the formula I.2 where R³ = methyl; R⁵ =cyclohexylmethyl; R⁴ = in each case one line of Table A.

TABLE 595 Compounds of the formula I.3 where R³ = methyl; R⁵ =cyclohexylmethyl; R⁴ = in each case one line of Table A.

TABLE 596 Compounds of the formula I.4 where R³ = methyl; R⁵ =cyclohexylmethyl; R⁴ = in each case one line of Table A.

TABLE A No. Ap R^(b) R^(a) a) R⁴ = 3-(C═O)—R^(a) 1 H 2 CH₃ 3 C₂H₅ 4n-C₃H₇ 5 i-C₃H₇ 6 cyclopropyl 7 n-C₄H₉ 8 s-C₄H₉ 9 i-C₄H₉ 10 t-C₄H₉ 11n-C₅H₁₁ 12 i-C₅H₁₁ 13 neo-C₅H₁₁ 14 cyclopentyl 15 n-C₆H₁₃ 16 cyclohexyl17 CH₂CN 18 CH₂OCH₃ 19 CH₂Cl 20 CF₃ 21 ethenyl b) R⁴ = 4-(C═O)—R^(a) 22H 23 CH₃ 24 C₂H₅ 25 n-C₃H₇ 26 i-C₃H₇ 27 cyclopropyl 28 n-C₄H₉ 29 s-C₄H₉30 i-C₄H₉ 31 t-C₄H₉ 32 n-C₅H₁₁ 33 i-C₅H₁₁ 34 neo-C₅H₁₁ 35 cyclopentyl 36n-C₆H₁₃ 37 cyclohexyl 38 CH₂CN 39 CH₂OCH₃ 40 CH₂Cl 41 CF₃ 42 ethenyl c)R⁴ = 3-C(═NOR^(a))—Ap—R^(b) 43 — CH₃ H 44 — CH₃ CH₃ 45 — CH₃ C₂H₅ 46 —CH₃ n-C₃H₇ 47 — CH₃ i-C₃H₇ 48 — CH₃ cyclopropyl 49 — CH₃ n-C₄H₉ 50 — CH₃s-C₄H₉ 51 — CH₃ i-C₄H₉ 52 — CH₃ t-C₄H₉ 53 — CH₃ n-C₅H₁₁ 54 — CH₃ i-C₅H₁₁55 — CH₃ neo-C₅H₁₁ 56 — CH₃ cyclopentyl 57 — CH₃ n-C₆H₁₃ 58 — CH₃cyclohexyl 59 — CH₃ CH₂CH₂Cl 60 — CH₃ (CH₂)₄Cl 61 — CH₃ CH₂CN 62 — CH₃CH₂CH₂CN 63 — CH₃ (CH₂)₃CN 64 — CH₃ (CH₂)₄CN 65 — CH₃ (CH₂)₆CN 66 — CH₃cyclohexylmethyl 67 — CH₃ 2-cyclohexyleth-1-yl 68 — CH₃cyclopropylmethyl 69 — CH₃ 2-cyclopropyleth-1-yl 70 — CH₃2-methoxyeth-1-yl 71 — CH₃ 2-ethoxyeth-1-yl 72 — CH₃2-isopropoxyeth-1-yl 73 — CH₃ 3-methoxyprop-1-yl 74 — CH₃3-ethoxyprop-1-yl 75 — CH₃ 3-isopropoxyprop-1-yl 76 — CH₃4-methoxybut-1-yl 77 — CH₃ 4-isopropoxybut-1-yl 78 — CH₃ propen-3-yl 79— CH₃ but-2-en-1-yl 80 — CH₃ 3-methylbut-2-en-1-yl 81 — CH₃2-vinyloxyeth-1-yl 82 — CH₃ allyloxyeth-1-yl 83 — CH₃2-trifluoromethoxyeth-1-yl 84 — CH₃ 3-trifluoromethoxyprop-1-yl 85 — CH₃4-difluoromethoxybut-1-yl 86 — CH₃ hydroxycarbonylmethyl 87 — CH₃methoxycarbonylmethyl 88 — CH₃ aminocarbonylmethyl 89 — CH₃N-methylaminocarbonylmethyl 90 — CH₃ N,N-dimethylaminocarbonyl-methyl 91— CH₃ 2-hydroxycarbonyleth-1-yl 92 — CH₃ 2-methoxycarbonyleth-1-yl 93 —CH₃ 2-aminocarbonyleth-1-yl 94 — CH₃ 2-N-methylaminocarbonyleth-1-yl 95— CH₃ 2-dimethylaminocarbonyleth-1-yl 96 — CH₃ 2-aminoeth-1-yl 97 — CH₃2-aminoprop-1-yl 98 — CH₃ 4-aminobut-1-yl 99 — CH₃3-dimethylaminoprop-1-yl 100 — CH₃ 4-aminothiocarbonylbut-1-yl 101 — CH₃6-aminocarbonylhex-1-yl 102 — CH₃ 3-aminothiocarbonylprop-1-yl 103 — CH₃2-aminothiocarbonyleth-1-yl 104 — CH₃ aminothiocarbonylmethyl 105 — CH₃4-(N,N-dimethylamino)but-1-yl 106 — CH₃ 2-(methylthio)eth-1-yl 107 — CH₃2-(methylsulfonyl)eth-1-yl 108 — CH₃ 4-(methylthio)prop-1-yl 109 — CH₃4-(methylsulfonyl)prop-1-yl 110 — CH₃ benzyl [sic] 111 — CH₃2-F—C₆H₄—CH₂ 112 — CH₃ 3-F—C₆H₄—CH₂ 113 — CH₃ 4-F—C₆H₄—CH₂ 114 — CH₃2,3-F₂—C₆H₃—CH₂ 115 — CH₃ 2,4-F₂—C₆H₃—CH₂ 116 — CH₃ 2,5-F₂—C₆H₃—CH₂ 117— CH₃ 2,6-F₂—C₆H₃—CH₂ 118 — CH₃ 3,4-F₂—C₆H₃—CH₂ 119 — CH₃3,5-F₂—C₆H₃—CH₂ 120 — CH₃ 2-Cl—C₆H₄—CH₂ 121 — CH₃ 3-Cl—C₆H₄—CH₂ 122 —CH₃ 4-Cl—C₆H₄—CH₂ 123 — CH₃ 2,3-Cl₂—C₆H₃—CH₂ 124 — CH₃ 2,4-Cl₂—C₆H₃—CH₂125 — CH₃ 2,5-Cl₂—C₆H₃—CH₂ 126 — CH₃ 2,6-Cl₂—C₆H₃—CH₂ 127 — CH₃3,4-Cl₂—C₆H₃—CH₂ 128 — CH₃ 3,5-Cl₂—C₆H₃—CH₂ 129 — CH₃ 2,3,4-Cl₃—C₆H₂—CH₂130 — CH₃ 2,3,5-Cl₃—C₆H₂—CH₂ 131 — CH₃ 2,3,6-Cl₃—C₆H₂—CH₂ 132 — CH₃2,4,5-Cl₃—C₆H₂—CH₂ 133 — CH₃ 2,4,6-Cl₃—C₆H₂—CH₂ 134 — CH₃3,4,5-Cl₃—C₆H₂—CH₂ 135 — CH₃ 2-Br—C₆H₄—CH₂ 136 — CH₃ 3-Br—C₆H₄—CH₂ 137 —CH₃ 4-Br—C₆H₄—CH₂ 138 — CH₃ 2,3-Br₂—C₆H₃—CH₂ 139 — CH₃ 2,4-Br₂—C₆H₃—CH₂140 — CH₃ 2,5-Br₂—C₆H₃—CH₂ 141 — CH₃ 2,6-Br₂—C₆H₃—CH₂ 142 — CH₃3,4-Br₂—C₆H₃—CH₂ 143 — CH₃ 3,5-Br₂—C₆H₃—CH₂ 144 — CH₃ 2-F, 3-Cl—C₆H₃—CH₂145 — CH₃ 2-F, 4-Cl—C₆H₃—CH₂ 146 — CH₃ 2-F, 5-Cl—C₆H₃—CH₂ 147 — CH₃ 2-F,3-Br—C₆H₃—CH₂ 148 — CH₃ 2-F, 4-Br—C₆H₃—CH₂ 149 — CH₃ 2-F, 5-Br—C₆H₃—CH₂150 — CH₃ 2-Cl, 3-Br—C₆H₃—CH₂ 151 — CH₃ 2-Cl, 4-Br—C₆H₃—CH₂ 152 — CH₃2-Cl, 5-Br—C₆H₃—CH₂ 153 — CH₃ 3-F, 4-Cl—C₆H₃—CH₂ 154 — CH₃ 3-F,5-Cl—C₆H₃—CH₂ 155 — CH₃ 3-F, 6-Cl—C₆H₃—CH₂ 156 — CH₃ 3-F, 4-Br—C₆H₃—CH₂157 — CH₃ 3-F, 5-Br—C₆H₃—CH₂ 158 — CH₃ 3-F, 6-Br—C₆H₃—CH₂ 159 — CH₃3-Cl, 4-Br—C₆H₃—CH₂ 160 — CH₃ 3-Cl, 5-Br—C₆H₃—CH₂ 161 — CH₃ 3-Cl,6-Br—C₆H₃—CH₂ 162 — CH₃ 4-F, 5-Cl—C₆H₃—CH₂ 163 — CH₃ 4-F, 6-Cl—C₆H₃—CH₂164 — CH₃ 4-F, 5-Br—C₆H₃—CH₂ 165 — CH₃ 4-F, 6-Br—C₆H₃—CH₂ 166 — CH₃4-Cl, 5-Br—C₆H₃—CH₂ 167 — CH₃ 5-F, 6-Cl—C₆H₃—CH₂ 168 — CH₃ 5-F,6-Br—C₆H₃—CH₂ 169 — CH₃ 5-Cl, 6-Br—C₆H₃—CH₂ 170 — CH₃ 3-Br, 4-Cl,5-Br—C₆H₂—CH₂ 171 — CH₃ 2-CN—C₆H₄—CH₂ 172 — CH₃ 3-CN—C₆H₄—CH₂ 173 — CH₃4-CN—C₆H₄—CH₂ 174 — CH₃ 2-NO₂—C₆H₄—CH₂ 175 — CH₃ 3-NO₂—C₆H₄—CH₂ 176 —CH₃ 4-NO₂—C₆H₄—CH₂ 177 — CH₃ 2-CH₃—C₆H₄—CH₂ 178 — CH₃ 3-CH₃—C₆H₄—CH₂ 179— CH₃ 4-CH₃—C₆H₄—CH₂ 180 — CH₃ 2,3-(CH₃)₂—C₆H₃—CH₂ 181 — CH₃2,4-(CH₃)₂—C₆H₃—CH₂ 182 — CH₃ 2,5-(CH₃)₂—C₆H₃—CH₂ 183 — CH₃2,6-(CH₃)₂—C₆H₃—CH₂ 184 — CH₃ 3,4-(CH₃)₂—C₆H₃—CH₂ 185 — CH₃3,5-(CH₃)₂—C₆H₃—CH₂ 186 — CH₃ 2-C₂H₅—C₆H₄—CH₂ 187 — CH₃ 3-C₂H₅—C₆H₄—CH₂188 — CH₃ 4-C₂H₅—C₆H₄—CH₂ 189 — CH₃ 2-i-C₃H₇—C₆H₄—CH₂ 190 — CH₃3-i-C₃H₇—C₆H₄—CH₂ 191 — CH₃ 4-i-C₃H₇—C₆H₄—CH₂ 192 — CH₃2-cyclohexyl-C₆H₄—CH₂ 193 — CH₃ 3-cyclohexyl-C₆H₄—CH₂ 194 — CH₃4-cyclohexyl-C₆H₄—CH₂ 195 — CH₃ 2-vinyl-C₆H₄—CH₂ 196 — CH₃3-vinyl-C₆H₄—CH₂ 197 — CH₃ 4-vinyl-C₆H₄—CH₂ 198 — CH₃ 2-allyl-C₆H₄—CH₂199 — CH₃ 3-allyl-C₆H₄—CH₂ 200 — CH₃ 4-allyl-C₆H₄—CH₂ 201 — CH₃2-C₆H₅—C₆H₄—CH₂ 202 — CH₃ 3-C₆H₅—C₆H₄—CH₂ 203 — CH₃ 4-C₆H₅—C₆H₄—CH₂ 204— CH₃ 3-CH₃, 5-t-C₄H₉—C₆H₃—CH₂ 205 — CH₃ 2-OH—C₆H₄—CH₂ 206 — CH₃3-OH—C₆H₄—CH₂ 207 — CH₃ 4-OH—C₆H₄—CH₂ 208 — CH₃ 2-OCH₃—C₆H₄—CH₂ 209 —CH₃ 3-OCH₃—C₆H₄—CH₂ 210 — CH₃ 4-OCH₃—C₆H₄—CH₂ 211 — CH₃2-O-allyl-C₆H₄—CH₂ 212 — CH₃ 3-O-allyl-C₆H₄—CH₂ 213 — CH₃4-O-allyl-C₆H₄—CH₂ 214 — CH₃ 2-CF₃—C₆H₄—CH₂ 215 — CH₃ 3-CF₃—C₆H₄—CH₂ 216— CH₃ 4-CF₃—C₆H₄—CH₂ 217 — CH₃ 2-acetyl-C₆H₄—CH₂ 218 — CH₃3-acetyl-C₆H₄—CH₂ 219 — CH₃ 4-acetyl-C₆H₄—CH₂ 220 — CH₃2-methoxycarbonyl-C₆H₄—CH₂ 221 — CH₃ 3-methoxycarbonyl-C₆H₄—CH₂ 222 —CH₃ 4-methoxycarbonyl-C₆H₄—CH₂ 223 — CH₃ 2-aminocarbonyl-C₆H₄—CH₂ 224 —CH₃ 3-aminocarbonyl-C₆H₄—CH₂ 225 — CH₃ 4-aminocarbonyl-C₆H₄—CH₂ 226 —CH₃ 2-dimethylaminocarbonyl-C₆H₄—CH₂ 227 — CH₃3-dimethylaminocarbonyl-C₆H₄—CH₂ 228 — CH₃4-dimethylaminocarbonyl-C₆H₄—CH₂ 229 — CH₃2-(N-methylaminocarbonyl)-C₆H₄—CH₂ 230 — CH₃3-(N-methylaminocarbonyl)-C₆H₄—CH₂ 231 — CH₃4-(N-methylaminocarbonyl)-C₆H₄—CH₂ 232 — CH₃ 2-H₂N—C₆H₄—CH₂ 233 — CH₃3-H₂N—C₆H₄—CH₂ 234 — CH₃ 4-H₂N—C₆H₄—CH₂ 235 — CH₃2-aminothiocarbonyl-C₆H₄—CH₂ 236 — CH₃ 3-aminothiocarbonyl-C₆H₄—CH₂ 237— CH₃ 4-aminothiocarbonyl-C₆H₄—CH₂ 238 — CH₃ 2-SCH₃—C₆H₄—CH₂ 239 — CH₃3-SCH₃—C₆H₄—CH₂ 240 — CH₃ 4-SCH₃—C₆H₄—CH₂ 241 — CH₃ 2-SO₂CH₃—C₆H₄—CH₂242 — CH₃ 3-SO₂CH₃—C₆H₄—CH₂ 243 — CH₃ 4-SO₂CH₃—C₆H₄—CH₂ 244 — CH₃2-OCF₃—C₆H₄—CH₂ 245 — CH₃ 3-OCF₃—C₆H₄—CH₂ 246 — CH₃ 4-OCF₃—C₆H₄—CH₂ 247— CH₃ 2-OCHF₂—C₆H₄—CH₂ 248 — CH₃ 3-OCHF₂—C₆H₄—CH₂ 249 — CH₃4-OCHF₂—C₆H₄—CH₂ 250 — CH₃ 3-CF₃, 4-OCF₃—C₆H₃—CH₂ 251 — CH₃1-naphthyl-CH₂ 252 — CH₃ 2-naphthyl-CH₂ 253 — CH₃ 2-phenoxyeth-1-yl 254— CH₃ 2-(2′-chlorophenoxy)eth-1-yl 255 — CH₃2-(3′-chlorophenoxy)eth-1-yl 256 — CH₃ 2-(4′-chlorophenoxy)eth-1-yl 257— CH₃ 2-(3′,5′-dichlorophenoxy)eth-1-yl 258 — CH₃2-(4′-cyanophenoxy)eth-1-yl 259 — CH₃ 2-(3′-methylphenoxy)eth-1-yl 260 —CH₃ 2-(2′-nitrophenoxy)eth-1-yl 261 — CH₃ 3-phenoxyprop-1-yl 262 — CH₃3-(4′-chlorophenoxy)prop-1-yl 263 — CH₃ 3-(3′-cyanophenoxy)prop-1-yl 264— CH₃ 3-(2′-methylphenoxy)prop-1-yl 265 — CH₃ 4-phenoxybut-1-yl 266 —CH₃ 2-phenyleth-1-yl 267 — CH₃ 2-(4′-chlorophenyl)eth-1-yl 268 — CH₃2-(3′-cyanophenyl)eth-1-yl 269 — CH₃ 2-(2′-methylphenyl)eth-1-yl 270 —CH₃ 3-phenylprop-1-yl 271 — CH₃ 4-phenylbut-1-yl 272 — CH₃2-pyridylmethyl 273 — CH₃ 3-pyridylmethyl 274 — CH₃ 4-pyridylmethyl 275— CH₃ 4-chloropyridin-2-ylmethyl 276 — CH₃ 5-chloropyridin-2-ylmethyl277 — CH₃ 6-chloropyridin-2-ylmethyl 278 — CH₃5-chloropyridin-3-ylmethyl 279 — CH₃ 6-chloropyridin-3-ylmethyl 280 —CH₃ 2-chloropyridin-4-ylmethyl 281 — CH₃ 2-pyrimidinylmethyl 282 — CH₃4-chloropyrimidin-2-ylmethyl 283 — CH₃ 5-chloropyrimidin-2-ylmethyl 284— CH₃ 2-chloropyrimidin-4-ylmethyl 285 — CH₃6-chloropyrimidin-4-ylmethyl 286 — CH₃ 2-chloropyrimidin-5-ylmethyl 287— CH₃ 4-pyridazinylmethyl 288 — CH₃ 2-pyrazinylmethyl 289 — CH₃5-chloropyrazin-2-ylmethyl 290 — CH₃ 6-chloropyrazin-2-ylmethyl 291 —CH₃ 3-pyridazinylmethyl 292 — CH₃ 6-chloropyridazin-3-ylmethyl 293 — CH₃1,3,5-triazinylmethyl 294 — CH₃ 2-furylmethyl 295 — CH₃ 3-furylmethyl296 — CH₃ 4-bromofur-2-ylmethyl 297 — CH₃ 5-chlorofur-2-ylmethyl 298 —CH₃ 2-thienylmethyl 299 — CH₃ 3-thienylmethyl 300 — CH₃5-methylthien-3-ylmethyl 301 — CH₃ 5-chlorothien-2-ylmethyl 302 — CH₃2-chlorothien-4-ylmethyl 303 — CH₃ 2-pyrrolylmethyl 304 — CH₃3-pyrrolylmethyl 305 — CH₃ 2-oxazolylmethyl 306 — CH₃4-methyloxazol-2-ylmethyl 307 — CH₃ 5-methyloxazol-2-ylmethyl 308 — CH₃4-chlorooxazol-2-ylmethyl 309 — CH₃ 5-chlorooxazol-2-ylmethyl 310 — CH₃4-oxazolylmethyl 311 — CH₃ 2-methyloxazol-4-ylmethyl 312 — CH₃5-methyloxazol-4-ylmethyl 313 — CH₃ 2-chlorooxazol-4-ylmethyl 314 — CH₃5-chlorooxazol-4-ylmethyl 315 — CH₃ 5-oxazolylmethyl 316 — CH₃2-methyloxazol-5-ylmethyl 317 — CH₃ 4-methyloxazol-5-ylmethyl 318 — CH₃2-chlorooxazol-5-ylmethyl 319 — CH₃ 4-chlorooxazol-5-ylmethyl 320 — CH₃2-thiazolylmethyl 321 — CH₃ 4-methylthiazol-2-ylmethyl 322 — CH₃5-methylthiazol-2-ylmethyl 323 — CH₃ 4-chlorothiazol-2-ylmethyl 324 —CH₃ 5-chlorothiazol-2-ylmethyl 325 — CH₃ 4-thiazolylmethyl 326 — CH₃2-methylthiazol-4-ylmethyl 327 — CH₃ 5-methylthiazol-4-ylmethyl 328 —CH₃ 2-chlorothiazol-4-ylmethyl 329 — CH₃ 5-chlorothiazol-4-ylmethyl 330— CH₃ 5-thiazolylmethyl 331 — CH₃ 2-methylthiazol-5-ylmethyl 332 — CH₃4-methylthiazol-5-ylmethyl 333 — CH₃ 2-chlorothiazol-5-ylmethyl 334 —CH₃ 4-chlorothiazol-5-ylmethyl 335 — CH₃ 3-isoxazolylmethyl 336 — CH₃4-methylisoxazol-3-ylmethyl 337 — CH₃ 5-methylisoxazol-3-ylmethyl 338 —CH₃ 4-chloroisoxazol-3-ylmethyl 339 — CH₃ 5-chloroisoxazol-3-ylmethyl340 — CH₃ 4-isoxazolylmethyl 341 — CH₃ 3-methylisoxazol-4-ylmethyl 342 —CH₃ 5-methylisoxazol-4-ylmethyl 343 — CH₃ 3-chloroisoxazol-4-ylmethyl344 — CH₃ 5-chloroisoxazol-4-ylmethyl 345 — CH₃ 5-isoxazolylmethyl 346 —CH₃ 3-methylisoxazol-5-ylmethyl 347 — CH₃ 4-methylisoxazol-5-ylmethyl348 — CH₃ 3-chloroisoxazol-5-ylmethyl 349 — CH₃4-chloroisoxazol-5-ylmethyl 350 — CH₃ 3-isothiazolylmethyl 351 — CH₃4-methylisothiazol-3-ylmethyl 352 — CH₃ 5-methylisothiazol-3-ylmethyl353 — CH₃ 4-chloroisothiazol-3-ylmethyl 354 — CH₃5-chloroisothiazol-3-ylmethyl 355 — CH₃ 4-isothiazolylmethyl 356 — CH₃3-methylisothiazol-4-ylmethyl 357 — CH₃ 5-methylisothiazol-4-ylmethyl358 — CH₃ 3-chloroisothiazol-4-ylmethyl 359 — CH₃5-chloroisothiazol-4-ylmethyl 360 — CH₃ 5-isothiazolylmethyl 361 — CH₃3-methylisothiazol-5-ylmethyl 362 — CH₃ 4-methylisothiazol-5-ylmethyl363 — CH₃ 3-chloroisothiazol-5-ylmethyl 364 — CH₃4-chloroisothiazol-5-ylmethyl 365 — CH₃ 4-imidazolylmethyl 366 — CH₃1-phenylpyrazol-3-ylmethyl 367 — CH₃ 1-methylimidazol-4-ylmethyl 368 —CH₃ 1-phenyl-1,2,4-triazol-3-ylmethyl 369 — CH₃1,2,4-oxadiazol-3-ylmethyl 370 — CH₃ 5-chloro-1,2,4-oxadiazol-3-ylmethyl371 — CH₃ 5-methyl-1,2,4-oxadiazol-3-ylmethyl 372 — CH₃5-trifluoromethyl-1,2,4-oxadiazol-3-ylmethyl 373 — CH₃1,3,4-oxadiazol-2-ylmethyl 374 — CH₃ 5-chloro-1,3,4-oxadiazol-2-ylmethyl375 — CH₃ 5-methyl-1,3,4-oxadiazol-2-ylmethyl 376 — CH₃5-methoxy-1,3,4-oxadiazol-2-ylmethyl 377 — CH₃1,2,4-thiadiazol-3-ylmethyl 378 — CH₃5-chloro-1,2,4-thiadiazol-3-ylmethyl 379 — CH₃5-methyl-1,2,4-thiadiazol-3-ylmethyl 380 — CH₃1,3,4-thiadiazol-2-ylmethyl 381 — CH₃5-chloro-1,3,4-thiadiazol-2-ylmethyl 382 — CH₃5-methyl-1,3,4-thiadiazol-2-ylmethyl 383 — CH₃5-cyano-1,3,4-thiadiazol-2-ylmethyl 384 — CH₃2-(2′-pyridinyloxy)eth-1-yl 385 — CH₃ 2-(3′-pyridinyloxy)eth-1-yl 386 —CH₃ 2-(4′-pyridinyloxy)eth-1-yl 387 — CH₃ C₆H₅ 388 — CH₃ 2-Cl—C₆H₄ 389 —CH₃ 3-Cl—C₆H₄ 390 — CH₃ 4-Cl—C₆H₄ 391 — CH₃ 2,3-Cl₂—C₆H₃ 392 — CH₃2,4-Cl₂—C₆H₃ 393 — CH₃ 2,5-Cl₂—C₆H₃ 394 — CH₃ 3,4-Cl₂—C₆H₃ 395 — CH₃3,5-Cl₂—C₆H₃ 396 — CH₃ 4-CN—C₆H₄ 397 — CH₃ 2-NO₂—C₆H₄ 398 — CH₃3-NO₂—C₆H₄ 399 — CH₃ 4-NO₂—C₆H₄ 400 — CH₃ 2,4-(NO₂)₂—C₆H₃ 401 — CH₃2-CH₃—C₆H₄ 402 — CH₃ 3-CH₃—C₆H₄ 403 — CH₃ 4-CH₃—C₆H₄ 404 — CH₃2,3-(CH₃)₂—C₆H₃ 405 — CH₃ 2,4-(CH₃)₂—C₆H₃ 406 — CH₃ 2,5-(CH₃)₂—C₆H₃ 407— CH₃ 2,6-(CH₃)₂—C₆H₃ 408 — CH₃ 2-C₆H₅—C₆H₄ 409 — CH₃ 3-C₆H₅—C₆H₄ 410 —CH₃ 4-C₆H₅—C₆H₄ 411 — CH₃ 3-OCH₃—C₆H₄ 412 — CH₃ 4-OCH₃—C₆H₄ 413 — CH₃3-acetyl-C₆H₄ 414 — CH₃ 4-acetyl-C₆H₄ 415 — CH₃ 3-methoxycarbonyl-C₆H₄416 — CH₃ 4-methoxycarbonyl-C₆H₄ 417 — CH₃ 3-CF₃—C₆H₄ 418 — CH₃4-CF₃—C₆H₄ 419 — CH₃ 2-naphthyl 420 — CH₃ 6-chloropyridazin-3-yl 421 —CH₃ 5-chloropyrazin-2-yl 422 — CH₃ quinolin-2-yl 423 — CH₃2,5-dimethylpyrazin-3-yl 424 — CH₃ pyrazin-2-yl 425 — CH₃3-chloropyrid-2-yl 426 — CH₃ 6-chloropyrid-2-yl 427 — CH₃4-trifluoromethyl, 6-chloropyrid-2-yl 428 — CH₃4-trifluoromethylpyrid-2-yl 429 — CH₃ 6-trifluoromethylpyrid-2-yl 430 —CH₃ 6-methoxypyrid-2-yl 431 — CH₃ 5-chloropyrid-2-yl 432 — CH₃pyrid-2-yl 433 — CH₃ benzothiazol-2-yl 434 — CH₃ 7-chloroquinolin-4-yl435 — CH₃ 3-nitropyrid-2-yl 436 — CH₃ pyrrol-3-yl 437 — CH₃ pyrrol-2-yl438 — CH₃ 2,6-dioctylpyrid-4-yl 439 — CH₃ 5-nitropyrid-2-yl 440 — CH₃pyrid-4-yl 441 — CH₃ pyrid-3-yl 442 — CH₃ pyrimidin-2-yl 443 — CH₃pyrimidin-4-yl 444 — CH₃ quinazolin-4-yl 445 — CH₃6-chloropyrimidin-4-yl 446 — CH₃ 6-methoxypyrimidin-4-yl 447 — CH₃2,5,6-trichloropyrimidin-4-yl 448 — CH₃ 2,6-dimethylpyrimidin-4-yl 449 —CH₃ 2-methyl, 6-chloropyrimidin-4-yl 450 — CH₃ 2-methyl,6-ethoxypyrimidin-4-yl 451 — CH₃ 4,5,6-trichloropyrimidin-2-yl 452 — CH₃4,6-dimethoxypyrimidin-2-yl 453 — CH₃ 4,6-dimethylpyrimidin-2-yl 454 —CH₃ 4,6-dichloropyrimidin-2-yl 455 — CH₃ 4-methyl,6-methoxypyrimidin-2-yl 456 — CH₃ 4-chloro, 6-methoxypyrimidin-2-yl 457— CH₃ 6-chloroquinoxalin-2-yl 458 — CH₃ 3,6-dichloro-1,2,4-triazin-5-yl459 — CH₃ 4-methoxy-1,3,5-triazin-2-yl 460 — CH₃4-ethoxy-1,3,5-triazin-2-yl 461 — CH₃ 4,6-dichloro-1,3,5-triazin-2-yl462 — CH₃ 4-ethoxy, 6-chloro-1,3,5-triazin-2-yl 463 — CH₃ isoxazol-3-yl464 — CH₃ thien-2-yl 465 — CH₃ fur-2-yl 466 — CH₃ thiatriazol-5-yl 467 —CH₃ (E)-1-chloropropen-3-yl 468 — CH₃(E)-4-(4′-chlorophenyl)but-2-en-1-yl 469 — CH₃ propyn-3-yl 470 — CH₃methylcarbonyl 471 — CH₃ 2-t-C₄H₉—C₆H₄—CH₂ 472 — CH₃ 3-t-C₄H₉—C₆H₄—CH₂473 — CH₃ 4-t-C₄H₉—C₆H₄—CH₂ 474 — CH₃2-(4′-chlorothiazol-2′-yloxy)eth-1-yl 475 — CH₃2-(1′-methylpyrazol-4′-yloxy)eth-1-yl 476 — CH₃ 4-Br—C₆H₄ 477 — CH₃3,5-(CH₃)₂—C₆H₃ 478 — CH₃ 4-C₂H₅—C₆H₄ 479 — CH₃3-dimethylaminocarbonyl-C₆H₄ 480 — CH₃ 4-dimethylaminocarbonyl-C₆H₄ 481— CH₃ 2-hydroxyprop-1-yl 482 — CH₃6-hydroxy-2-methylpyrimidin-4-ylmethyl 483 — CH₃[6-OH,2-CH(CH₃)₂-pyrimidin-4-yl]-CH₂ 484 — CH₃[6-OH,2-CH(CH₂)₂-pyrimidin-4-yl]-CH₂ 1 — CH₃ 5-(2′-furan)pent-1-yl 2 —CH₃ 5-(2′-N-methylpyrrole)pent-1-yl 3 — CH₃[2-(4-Cl—C₆H₄)-oxazol-4-yl]-CH₂ 4 — CH₃ 3-CF₃-pyridin-2-yl 5 — CH₃5-CF₃-pyridin-2-yl 6 — CH₃ 6-(2′-thienyl)hex-1-yl 7 — H H 8 — H CH₃ 9 —H C₂H₅ 10 — H n-C₃H₇ 11 — H i-C₃H₇ 12 — H cyclopropyl 13 — H n-C₄H₉ 14 —H s-C₄H₉ 15 — H i-C₄H₉ 16 — H t-C₄H₉ 17 — H n-C₅H₁₁ 18 H i-C₅H₁₁ 19 — Hneo-C₅H₁₁ 20 — H cyclopentyl 21 — H n-C₆H₁₃ 22 — H cyclohexyl 23 — HCH₂CH₂Cl 24 — H (CH₂)₄Cl 25 — H CH₂CN 26 — H CH₂CH₂CN 27 — H (CH₂)₃CN 28— H (CH₂)₄CN 29 — H (CH₂)₆CN 30 — H cyclohexylmethyl 31 — H2-cyclohexyleth-1-yl 32 — H cyclopropylmethyl 33 — H2-cyclopropyleth-1-yl 34 — H 2-methoxyeth-1-yl 35 — H 2-ethoxyeth-1-yl36 — H 2-isopropoxyeth-1-yl 37 — H 3-methoxyprop-1-yl 38 — H3-ethoxyprop-1-yl 39 — H 3-isopropoxyprop-1-yl 40 — H 4-methoxybut-1-yl41 — H 4-isopropoxybut-1-yl 42 — H propen-3-yl 43 — H but-2-en-1-yl 44 —H 3-methylbut-2-en-1-yl 45 — H 2-vinyloxyeth-1-yl 46 — Hallyloxyeth-1-yl 47 — H 2-trifluoromethoxyeth-1-yl 48 — H3-trifluoromethoxyprop-1-yl 49 — H 4-difluoromethoxybut-1-yl 50 — Hhydroxycarbonylmethyl 51 — H methoxycarbonylmethyl 52 — Haminocarbonylmethyl 53 — H N-methylaminocarbonylmethyl 54 — HN,N-dimethylaminocarbonyl-methyl 55 — H 2-hydroxycarbonyleth-1-yl 56 — H2-methoxycarbonyleth-1-yl 57 — H 2-aminocarbonyleth-1-yl 58 — H2-N-methylaminocarbonyleth-1-yl 59 — H 2-dimethylaminocarbonyleth-1-yl60 — H 2-aminoeth-1-yl 61 — H 2-aminoprop-1-yl 62 — H 4-aminobut-1-yl 63— H 3-dimethylaminoprop-1-yl 64 — H 4-aminothiocarbonylbut-1-yl 65 — H6-aminocarbonylhex-1-yl 66 — H 3-aminothiocarbonylprop-1-yl 67 — H2-aminothiocarbonyleth-1-yl 68 — H aminothiocarbonylmethyl 69 — H4-(N,N-dimethylamino)but-1-yl 70 — H 2-(methylthio)eth-1-yl 71 — H2-(methylsulfonyl)eth-1-yl 72 — H 4-(methylthio)prop-1-yl 73 — H4-(methylsulfonyl)prop-1-yl 74 — H benzyl 75 — H 2-F—C₆H₄—CH₂ 76 — H3-F—C₆H₄—CH₂ 77 — H 4-F—C₆H₄—CH₂ 78 — H 2,3-F₂—C₆H₃—CH₂ 79 — H2,4-F₂—C₆H₃—CH₂ 80 — H 2,5-F₂—C₆H₃—CH₂ 81 — H 2,6-F₂—C₆H₃—CH₂ 82 — H3,4-F₂—C₆H₃—CH₂ 83 — H 3,5-F₂—C₆H₃—CH₂ 84 — H 2-Cl—C₆H₄—CH₂ 85 — H3-Cl—C₆H₄—CH₂ 86 — H 4-Cl—C₆H₄—CH₂ 87 — H 2,3-Cl₂—C₆H₃—CH₂ 88 — H2,4-Cl₂—C₆H₃—CH₂ 89 — H 2,5-Cl₂—C₆H₃—CH₂ 90 — H 2,6-Cl₂—C₆H₃—CH₂ 91 — H3,4-Cl₂—C₆H₃—CH₂ 92 — H 3,5-Cl₂—C₆H₃—CH₂ 93 — H 2,3,4-Cl₃—C₆H₂—CH₂ 94 —H 2,3,5-Cl₃—C₆H₂—CH₂ 95 — H 2,3,6-Cl₃—C₆H₂—CH₂ 96 — H 2,4,5-Cl₃—C₆H₂—CH₂97 — H 2,4,6-Cl₃—C₆H₂—CH₂ 98 — H 3,4,5-Cl₃—C₆H₂—CH₂ 99 — H 2-Br—C₆H₄—CH₂100 — H 3-Br—C₆H₄—CH₂ 101 — H 4-Br—C₆H₄—CH₂ 102 — H 2,3-Br₂—C₆H₃—CH₂ 103— H 2,4-Br₂—C₆H₃—CH₂ 104 — H 2,5-Br₂—C₆H₃—CH₂ 105 — H 2,6-Br₂—C₆H₃—CH₂106 — H 3,4-Br₂—C₆H₃—CH₂ 107 — H 3,5-Br₂—C₆H₃—CH₂ 108 — H 2-F,3-Cl—C₆H₃—CH₂ 109 — H 2-F, 4-Cl—C₆H₃—CH₂ 110 — H 2-F, 5-Cl—C₆H₃—CH₂ 111— H 2-F, 3-Br—C₆H₃—CH₂ 112 — H 2-F, 4-Br—C₆H₃—CH₂ 113 — H 2-F,5-Br—C₆H₃—CH₂ 114 — H 2-Cl, 3-Br—C₆H₃—CH₂ 115 — H 2-Cl, 4-Br—C₆H₃—CH₂116 — H 2-Cl, 5-Br—C₆H₃—CH₂ 117 — H 3-F, 4-Cl—C₆H₃—CH₂ 118 — H 3-F,5-Cl—C₆H₃—CH₂ 119 — H 3-F, 6-Cl—C₆H₃—CH₂ 120 — H 3-F, 4-Br—C₆H₃—CH₂ 121— H 3-F, 5-Br—C₆H₃—CH₂ 122 — H 3-F, 6-Br—C₆H₃—CH₂ 123 — H 3-Cl,4-Br—C₆H₃—CH₂ 124 — H 3-Cl, 5-Br—C₆H₃—CH₂ 125 — H 3-Cl, 6-Br—C₆H₃—CH₂126 — H 4-F, 5-Cl—C₆H₃—CH₂ 127 — H 4-F, 6-Cl—C₆H₃—CH₂ 128 — H 4-F,5-Br—C₆H₃—CH₂ 129 — H 4-F, 6-Br—C₆H₃—CH₂ 130 — H 4-Cl, 5-Br—C₆H₃—CH₂ 131— H 5-F, 6-Cl—C₆H₃—CH₂ 132 — H 5-F, 6-Br—C₆H₃—CH₂ 133 — H 5-Cl,6-Br—C₆H₃—CH₂ 134 — H 3-Br, 4-Cl, 5-Br—C₆H₂—CH₂ 135 — H 2-CN—C₆H₄—CH₂136 — H 3-CN—C₆H₄—CH₂ 137 — H 4-CN—C₆H₄—CH₂ 138 — H 2-NO₂—C₆H₄—CH₂ 139 —H 3-NO₂—C₆H₄—CH₂ 140 — H 4-NO₂—C₆H₄—CH₂ 141 — H 2-CH₃—C₆H₄—CH₂ 142 — H3-CH₃—C₆H₄—CH₂ 143 — H 4-CH₃—C₆H₄—CH₂ 144 — H 2,3-(CH₃)₂—C₆H₃—CH₂ 145 —H 2,4-(CH₃)₂—C₆H₃—CH₂ 146 — H 2,5-(CH₃)₂—C₆H₃—CH₂ 147 — H2,6-(CH₃)₂—C₆H₃—CH₂ 148 — H 3,4-(CH₃)₂—C₆H₃—CH₂ 149 — H3,5-(CH₃)₂—C₆H₃—CH₂ 150 — H 2-C₂H₅—C₆H₄—CH₂ 151 — H 3-C₂H₅—C₆H₄—CH₂ 152— H 4-C₂H₅—C₆H₄—CH₂ 153 — H 2-i-C₃H₇—C₆H₄—CH₂ 154 — H 3-i-C₃H₇—C₆H₄—CH₂155 — H 4-i-C₃H₇—C₆H₄—CH₂ 156 — H 2-cyclohexyl-C₆H₄—CH₂ 157 — H3-cyclohexyl-C₆H₄—CH₂ 158 — H 4-cyclohexyl-C₆H₄—CH₂ 159 — H2-vinyl-C₆H₄—CH₂ 160 — H 3-vinyl-C₆H₄—CH₂ 161 — H 4-vinyl-C₆H₄—CH₂ 162 —H 2-allyl-C₆H₄—CH₂ 163 — H 3-allyl-C₆H₄—CH₂ 164 — H 4-allyl-C₆H₄—CH₂ 165— H 2-C₆H₅—C₆H₄—CH₂ 166 — H 3-C₆H₅—C₆H₄—CH₂ 167 — H 4-C₆H₅—C₆H₄—CH₂ 168— H 3-CH₃, 5-t-C₄H₉—C₆H₃—CH₂ 169 — H 2-OH—C₆H₄—CH₂ 170 — H 3-OH—C₆H₄—CH₂171 — H 4-OH—C₆H₄—CH₂ 172 — H 2-OCH₃—C₆H₄—CH₂ 173 — H 3-OCH₃—C₆H₄—CH₂174 — H 4-OCH₃—C₆H₄—CH₂ 175 — H 2-O-allyl-C₆H₄—CH₂ 176 — H3-O-allyl-C₆H₄—CH₂ 177 — H 4-O-allyl-C₆H₄—CH₂ 178 — H 2-CF₃—C₆H₄—CH₂ 179— H 3-CF₃—C₆H₄—CH₂ 180 — H 4-CF₃—C₆H₄—CH₂ 181 — H 2-acetyl-C₆H₄—CH₂ 182— H 3-acetyl-C₆H₄—CH₂ 183 — H 4-acetyl-C₆H₄—CH₂ 184 — H2-methoxycarbonyl-C₆H₄—CH₂ 185 — H 3-methoxycarbonyl-C₆H₄—CH₂ 186 — H4-methoxycarbonyl-C₆H₄—CH₂ 187 — H 2-aminocarbonyl-C₆H₄—CH₂ 188 — H3-aminocarbonyl-C₆H₄—CH₂ 189 — H 4-aminocarbonyl-C₆H₄—CH₂ 190 — H2-dimethylaminocarbonyl-C₆H₄—CH₂ 191 — H3-dimethylaminocarbonyl-C₆H₄—CH₂ 192 — H4-dimethylaminocarbonyl-C₆H₄—CH₂ 193 — H2-(N-methylaminocarbonyl)-C₆H₄—CH₂ 194 — H3-(N-methylaminocarbonyl)-C₆H₄—CH₂ 195 — H4-(N-methylaminocarbonyl)-C₆H₄—CH₂ 196 — H 2-H₂N—C₆H₄—CH₂ 197 — H3-H₂N—C₆H₄—CH₂ 198 — H 4-H₂N—C₆H₄—CH₂ 199 — H2-aminothiocarbonyl-C₆H₄—CH₂ 200 — H 3-aminothiocarbonyl-C₆H₄—CH₂ 201 —H 4-aminothiocarbonyl-C₆H₄—CH₂ 202 — H 2-SCH₃—C₆H₄—CH₂ 203 — H3-SCH₃—C₆H₄—CH₂ 204 — H 4-SCH₃—C₆H₄—CH₂ 205 — H 2-SO₂CH₃—C₆H₄—CH₂ 206 —H 3-SO₂CH₃—C₆H₄—CH₂ 207 — H 4-SO₂CH₃—C₆H₄—CH₂ 208 — H 2-OCF₃—C₆H₄—CH₂209 — H 3-OCF₃—C₆H₄—CH₂ 210 — H 4-OCF₃—C₆H₄—CH₂ 211 — H 2-OCHF₂—C₆H₄—CH₂212 — H 3-OCHF₂—C₆H₄—CH₂ 213 — H 4-OCHF₂—C₆H₄—CH₂ 214 — H 3-CF₃,4-OCF₃—C₆H₃—CH₂ 215 — H 1-naphthyl-CH₂ 216 — H 2-naphthyl-CH₂ 217 — H2-phenoxyeth-1-yl 218 — H 2-(2′-chlorophenoxy)eth-1-yl 219 — H2-(3′-chlorophenoxy)eth-1-yl 220 — H 2-(4′-chlorophenoxy)eth-1-yl 221 —H 2-(3′,5′-dichlorophenoxy)eth-1-yl 222 — H 2-(4′-cyanophenoxy)eth-1-yl223 — H 2-(3′-methylphenoxy)eth-1-yl 224 — H 2-(2′-nitrophenoxy)eth-1-yl225 — H 3-phenoxyprop-1-yl 226 — H 3-(4′-chlorophenoxy)prop-1-yl 227 — H3-(3′-cyanophenoxy)prop-1-yl 228 — H 3-(2′-methylphenoxy)prop-1-yl 229 —H 4-phenoxybut-1-yl 230 — H 2-phenyleth-1-yl 231 — H2-(4′-chlorophenyl)eth-1-yl 232 — H 2-(3′-cyanophenyl)eth-1-yl 233 — H2-(2′-methylphenyl)eth-1-yl 234 — H 3-phenylprop-1-yl 235 — H4-phenylbut-1-yl 236 — H 2-pyridylmethyl 237 — H 3-pyridylmethyl 238 — H4-pyridylmethyl 239 — H 4-chloropyridin-2-ylmethyl 240 — H5-chloropyridin-2-ylmethyl 241 — H 6-chloropyridin-2-ylmethyl 242 — H5-chloropyridin-3-ylmethyl 243 — H 6-chloropyridin-3-ylmethyl 244 — H2-chloropyridin-4-ylmethyl 245 — H 2-pyrimidinylmethyl 246 — H4-chloropyrimidin-2-ylmethyl 247 — H 5-chloropyrimidin-2-ylmethyl 248 —H 2-chloropyrimidin-4-ylmethyl 249 — H 6-chloropyrimidin-4-ylmethyl 250— H 2-chloropyrimidin-5-ylmethyl 251 — H 4-pyridazinylmethyl 252 — H2-pyrazinylmethyl 253 — H 5-chloropyrazin-2-ylmethyl 254 — H6-chloropyrazin-2-ylmethyl 255 — H 3-pyridazinylmethyl 256 — H6-chloropyridazin-3-ylmethyl 257 — H 1,3,5-triazinylmethyl 258 — H2-furylmethyl 259 — H 3-furylmethyl 260 — H 4-bromofur-2-ylmethyl 261 —H 5-chlorofur-2-ylmethyl 262 — H 2-thienylmethyl 263 — H 3-thienylmethyl264 — H 5-methylthien-3-ylmethyl 265 — H 5-chlorothien-2-ylmethyl 266 —H 2-chlorothien-4-ylmethyl 267 — H 2-pyrrolylmethyl 268 — H3-pyrrolylmethyl 269 — H 2-oxazolylmethyl 270 — H4-methyloxazol-2-ylmethyl 271 — H 5-methyloxazol-2-ylmethyl 272 — H4-chlorooxazol-2-ylmethyl 273 — H 5-chlorooxazol-2-ylmethyl 274 — H4-oxazolylmethyl 275 — H 2-methyloxazol-4-ylmethyl 276 — H5-methyloxazol-4-ylmethyl 277 — H 2-chlorooxazol-4-ylmethyl 278 — H5-chlorooxazol-4-ylmethyl 279 — H 5-oxazolylmethyl 280 — H2-methyloxazol-5-ylmethyl 281 — H 4-methyloxazol-5-ylmethyl 282 — H2-chlorooxazol-5-ylmethyl 283 — H 4-chlorooxazol-5-ylmethyl 284 — H2-thiazolylmethyl 285 — H 4-methylthiazol-2-ylmethyl 286 — H5-methylthiazol-2-ylmethyl 287 — H 4-chlorothiazol-2-ylmethyl 288 — H5-chlorothiazol-2-ylmethyl 289 — H 4-thiazolylmethyl 290 — H2-methylthiazol-4-ylmethyl 291 — H 5-methylthiazol-4-ylmethyl 292 — H2-chlorothiazol-4-ylmethyl 293 — H 5-chlorothiazol-4-ylmethyl 294 — H5-thiazolylmethyl 295 — H 2-methylthiazol-5-ylmethyl 296 — H4-methylthiazol-5-ylmethyl 297 — H 2-chlorothiazol-5-ylmethyl 298 — H4-chlorothiazol-5-ylmethyl 299 — H 3-isoxazolylmethyl 300 — H4-methylisoxazol-3-ylmethyl 301 — H 5-methylisoxazol-3-ylmethyl 302 — H4-chloroisoxazol-3-ylmethyl 303 — H 5-chloroisoxazol-3-ylmethyl 304 — H4-isoxazolylmethyl 305 — H 3-methylisoxazol-4-ylmethyl 306 — H5-methylisoxazol-4-ylmethyl 307 — H 3-chloroisoxazol-4-ylmethyl 308 — H5-chloroisoxazol-4-ylmethyl 309 — H 5-isoxazolylmethyl 310 — H3-methylisoxazol-5-ylmethyl 311 — H 4-methylisoxazol-5-ylmethyl 312 — H3-chloroisoxazol-5-ylmethyl 313 — H 4-chloroisoxazol-5-ylmethyl 314 — H3-isothiazolylmethyl 315 — H 4-methylisothiazol-3-ylmethyl 316 — H5-methylisothiazol-3-ylmethyl 317 — H 4-chloroisothiazol-3-ylmethyl 318— H 5-chloroisothiazol-3-ylmethyl 319 — H 4-isothiazolylmethyl 320 — H3-methylisothiazol-4-ylmethyl 321 — H 5-methylisothiazol-4-ylmethyl 322— H 3-chloroisothiazol-4-ylmethyl 323 — H 5-chloroisothiazol-4-ylmethyl324 — H 5-isothiazolylmethyl 325 — H 3-methylisothiazol-5-ylmethyl 326 —H 4-methylisothiazol-5-ylmethyl 327 — H 3-chloroisothiazol-5-ylmethyl328 — H 4-chloroisothiazol-5-ylmethyl 329 — H 4-imidazolylmethyl 330 — H1-phenylpyrazol-3-ylmethyl 331 — H 1-methylimidazol-4-ylmethyl 332 — H1-phenyl-1,2,4-triazol-3-ylmethyl 333 — H 1,2,4-oxadiazol-3-ylmethyl 334— H 5-chloro-1,2,4-oxadiazol-3-ylmethyl 335 — H5-methyl-1,2,4-oxadiazol-3-ylmethyl 336 — H5-trifluoromethyl-1,2,4-oxadiazol-3-ylmethyl 337 — H1,3,4-oxadiazol-2-ylmethyl 338 — H 5-chloro-1,3,4-oxadiazol-2-ylmethyl339 — H 5-methyl-1,3,4-oxadiazol-2-ylmethyl 340 — H5-methoxy-1,3,4-oxadiazol-2-ylmethyl 341 — H 1,2,4-thiadiazol-3-ylmethyl342 — H 5-chloro-1,2,4-thiadiazol-3-ylmethyl 343 — H5-methyl-1,2,4-thiadiazol-3-ylmethyl 344 — H 1,3,4-thiadiazol-2-ylmethyl345 — H 5-chloro-1,3,4-thiadiazol-2-ylmethyl 346 — H5-methyl-1,3,4-thiadiazol-2-ylmethyl 347 — H5-cyano-1,3,4-thiadiazol-2-ylmethyl 348 — H 2-(2′-pyridinyloxy)eth-1-yl349 — H 2-(3′-pyridinyloxy)eth-1-yl 350 — H 2-(4′-pyridinyloxy)eth-1-yl351 — H C₆H₅ 352 — H 2-Cl—C₆H₄ 353 — H 3-Cl—C₆H₄ 354 — H 4-Cl—C₆H₄ 355 —H 2,3-Cl₂—C₆H₃ 356 — H 2,4-Cl₂—C₆H₃ 357 — H 2,5-Cl₂—C₆H₃ 358 — H3,4-Cl₂—C₆H₃ 359 — H 3,5-Cl₂—C₆H₃ 360 — H 4-CN—C₆H₄ 361 — H 2-NO₂—C₆H₄362 — H 3-NO₂—C₆H₄ 363 — H 4-NO₂—C₆H₄ 364 — H 2,4-(NO₂)₂—C₆H₃ 365 — H2-CH₃—C₆H₄ 366 — H 3-CH₃—C₆H₄ 367 — H 4-CH₃—C₆H₄ 368 — H 2,3-(CH₃)₂—C₆H₃369 — H 2,4-(CH₃)₂—C₆H₃ 370 — H 2,5-(CH₃)₂—C₆H₃ 371 — H 2,6-(CH₃)₂—C₆H₃372 — H 2-C₆H₅—C₆H₄ 373 — H 3-C₆H₅—C₆H₄ 374 — H 4-C₆H₅—C₆H₄ 375 — H3-OCH₃—C₆H₄ 376 — H 4-OCH₃—C₆H₄ 377 — H 3-acetyl-C₆H₄ 378 — H4-acetyl-C₆H₄ 379 — H 3-methoxycarbonyl-C₆H₄ 380 — H4-methoxycarbonyl-C₆H₄ 381 — H 3-CF₃—C₆H₄ 382 — H 4-CF₃—C₆H₄ 383 — H2-naphthyl 384 — H 6-chloropyridazin-3-yl 385 — H 5-chloropyrazin-2-yl386 — H quinolin-2-yl 387 — H 2,5-dimethylpyrazin-3-yl 388 — Hpyrazin-2-yl 389 — H 3-chloropyrid-2-yl 390 — H 6-chloropyrid-2-yl 391 —H 4-trifluoromethyl, 6-chloropyrid-2-yl 392 — H4-trifluoromethylpyrid-2-yl 393 — H 6-trifluoromethylpyrid-2-yl 394 — H6-methoxypyrid-2-yl 395 — H 5-chloropyrid-2-yl 396 — H pyrid-2-yl 397 —H benzothiazol-2-yl 398 — H 7-chloroquinolin-4-yl 399 — H3-nitropyrid-2-yl 400 — H pyrrol-3-yl 401 — H pyrrol-2-yl 402 — H2,6-dioctylpyrid-4-yl 403 — H 5-nitropyrid-2-yl 404 — H pyrid-4-yl 405 —H pyrid-3-yl 406 — H pyrimidin-2-yl 407 — H pyrimidin-4-yl 408 — Hquinazolin-4-yl 409 — H 6-chloropyrimidin-4-yl 410 — H6-methoxypyrimidin-4-yl 411 — H 2,5,6-trichloropyrimidin-4-yl 412 — H2,6-dimethylpyrimidin-4-yl 413 — H 2-methyl, 6-chloropyrimidin-4-yl 414— H 2-methyl, 6-ethoxypyrimidin-4-yl 415 — H4,5,6-trichloropyrimidin-2-yl 416 — H 4,6-dimethoxypyrimidin-2-yl 417 —H 4,6-dimethylpyrimidin-2-yl 418 — H 4,6-dichloropyrimidin-2-yl 419 — H4-methyl, 6-methoxypyrimidin-2-yl 420 — H 4-chloro,6-methoxypyrimidin-2-yl 421 — H 6-chloroquinoxalin-2-yl 422 — H3,6-dichloro-1,2,4-triazin-5-yl 423 — H 4-methoxy-1,3,5-triazin-2-yl 424— H 4-ethoxy-1,3,5-triazin-2-yl 425 — H 4,6-dichloro-1,3,5-triazin-2-yl426 — H 4-ethoxy, 6-chloro-1,3,5-triazin-2-yl 427 — H isoxazol-3-yl 428— H thien-2-yl 429 — H fur-2-yl 430 — H thiatriazol-5-yl 431 — H(E)-1-chloropropen-3-yl 432 — H (E)-4-(4′-chlorophenyl)but-2-en-1-yl 433— H propyn-3-yl 434 — H methylcarbonyl 435 — H 2-t-C₄H₉—C₆H₄—CH₂ 436 — H3-t-C₄H₉—C₆H₄—CH₂ 437 — H 4-t-C₄H₉—C₆H₄—CH₂ 438 — H2-(4′-chlorothiazol-2′-yloxy)eth-1-yl 439 — H2-(1′-methylpyrazol-4′-yloxy)eth-1-yl 440 — H 4-Br—C₆H₄ 441 — H3,5-(CH₃)₂—C₆H₃ 442 — H 4-C₂H₅—C₆H₄ 443 — H 3-dimethylaminocarbonyl-C₆H₄444 — H 4-dimethylaminocarbonyl-C₆H₄ 445 — H 2-hydroxyprop-1-yl 446 — H6-hydroxy-2-methylpyrimidin-4-ylmethyl 447 — H[6-OH,2-CH(CH₃)₂-pyrimidin-4-yl]-CH₂ 448 — H[6-OH,2-CH(CH₂)₂-pyrimidin-4-yl]-CH₂ 449 — H 5-(2′-furan)pent-1-yl 450 —H 5-(2′-N-methylpyrrole)pent-1-yl 451 — H[2-(4-Cl—C₆H₄)-oxazol-4-yl]-CH₂ 452 — H 3-CF₃-pyridin-2-yl 453 — H5-CF₃-pyridin-2-yl 454 — H 6-(2′-thienyl)hex-1-yl 455 O CH₃ H 456 O CH₃CH₃ 457 O CH₃ C₂H₅ 458 O CH₃ n-C₃H₇ 459 O CH₃ i-C₃H₇ 460 O CH₃cyclopropyl 461 O CH₃ n-C₄H₉ 462 O CH₃ s-C₄H₉ 463 O CH₃ i-C₄H₉ 464 O CH₃t-C₄H₉ 465 O CH₃ n-C₅H₁₁ 466 O CH₃ i-C₅H₁₁ 467 O CH₃ neo-C₅H₁₁ 468 O CH₃cyclopentyl 469 O CH₃ n-C₆H₁₃ 470 O CH₃ cyclohexyl 471 O CH₃ CH₂CH₂Cl472 O CH₃ (CH₂)₄Cl 473 O CH₃ CH₂CN 474 O CH₃ CH₂CH₂CN 475 O CH₃ (CH₂)₃CN476 O CH₃ (CH₂)₄CN 477 O CH₃ (CH₂)₆CN 478 O CH₃ cyclohexylmethyl 479 OCH₃ 2-cyclohexyleth-1-yl 480 O CH₃ cyclopropylmethyl 481 O CH₃2-cyclopropyleth-1-yl 482 O CH₃ 2-methoxyeth-1-yl 483 O CH₃2-ethoxyeth-1-yl 484 O CH₃ 2-isopropoxyeth-1-yl 485 O CH₃3-methoxyprop-1-yl 486 O CH₃ 3-ethoxyprop-1-yl 487 O CH₃3-isopropoxyprop-1-yl 488 O CH₃ 4-methoxybut-1-yl 489 O CH₃4-isopropoxybut-1-yl 490 O CH₃ propen-3-yl 491 O CH₃ but-2-en-1-yl 492 OCH₃ 3-methylbut-2-en-1-yl 493 O CH₃ 2-vinyloxyeth-1-yl 494 O CH₃allyloxyeth-1-yl 495 O CH₃ 2-trifluoromethoxyeth-1-yl 496 O CH₃3-trifluoromethoxyprop-1-yl 497 O CH₃ 4-difluoromethoxybut-1-yl 498 OCH₃ hydroxycarbonylmethyl 499 O CH₃ methoxycarbonylmethyl 500 O CH₃aminocarbonylmethyl 501 O CH₃ N-methylaminocarbonylmethyl 502 O CH₃N,N-dimethylaminocarbonyl-methyl 503 O CH₃ 2-hydroxycarbonyleth-1-yl 504O CH₃ 2-methoxycarbonyleth-1-yl 505 O CH₃ 2-aminocarbonyleth-1-yl 506 OCH₃ 2-N-methylaminocarbonyleth-1-yl 507 O CH₃2-dimethylaminocarbonyleth-1-yl 508 O CH₃ 2-aminoeth-1-yl 509 O CH₃2-aminoprop-1-yl 510 O CH₃ 4-aminobut-1-yl 511 O CH₃3-dimethylaminoprop-1-yl 512 O CH₃ 4-aminothiocarbonylbut-1-yl 513 O CH₃6-aminocarbonylhex-1-yl 514 O CH₃ 3-aminothiocarbonylprop-1-yl 515 O CH₃2-aminothiocarbonyleth-1-yl 516 O CH₃ aminothiocarbonylmethyl 517 O CH₃4-(N,N-dimethylamino)but-1-yl 518 O CH₃ 2-(methylthio)eth-1-yl 519 O CH₃2-(methylsulfonyl)eth-1-yl 520 O CH₃ 4-(methylthio)prop-1-yl 521 O CH₃4-(methylsulfonyl)prop-1-yl 522 O CH₃ benzyl 523 O CH₃ 2-F—C₆H₄—CH₂ 524O CH₃ 3-F—C₆H₄—CH₂ 525 O CH₃ 4-F—C₆H₄—CH₂ 526 O CH₃ 2,3-F₂—C₆H₃—CH₂ 527O CH₃ 2,4-F₂—C₆H₃—CH₂ 528 O CH₃ 2,5-F₂—C₆H₃—CH₂ 529 O CH₃2,6-F₂—C₆H₃—CH₂ 530 O CH₃ 3,4-F₂—C₆H₃—CH₂ 531 O CH₃ 3,5-F₂—C₆H₃—CH₂ 532O CH₃ 2-Cl—C₆H₄—CH₂ 533 O CH₃ 3-Cl—C₆H₄—CH₂ 534 O CH₃ 4-Cl—C₆H₄—CH₂ 535O CH₃ 2,3-Cl₂—C₆H₃—CH₂ 536 O CH₃ 2,4-Cl₂—C₆H₃—CH₂ 537 O CH₃2,5-Cl₂—C₆H₃—CH₂ 538 O CH₃ 2,6-Cl₂—C₆H₃—CH₂ 539 O CH₃ 3,4-Cl₂—C₆H₃—CH₂540 O CH₃ 3,5-Cl₂—C₆H₃—CH₂ 541 O CH₃ 2,3,4-Cl₃—C₆H₂—CH₂ 542 O CH₃2,3,5-Cl₃—C₆H₂—CH₂ 543 O CH₃ 2,3,6-Cl₃—C₆H₂—CH₂ 544 O CH₃2,4,5-Cl₃—C₆H₂—CH₂ 545 O CH₃ 2,4,6-Cl₃—C₆H₂—CH₂ 546 O CH₃3,4,5-Cl₃—C₆H₂—CH₂ 547 O CH₃ 2-Br—C₆H₄—CH₂ 548 O CH₃ 3-Br—C₆H₄—CH₂ 549 OCH₃ 4-Br—C₆H₄—CH₂ 550 O CH₃ 2,3-Br₂—C₆H₃—CH₂ 551 O CH₃ 2,4-Br₂—C₆H₃—CH₂552 O CH₃ 2,5-Br₂—C₆H₃—CH₂ 553 O CH₃ 2,6-Br₂—C₆H₃—CH₂ 554 O CH₃3,4-Br₂—C₆H₃—CH₂ 555 O CH₃ 3,5-Br₂—C₆H₃—CH₂ 556 O CH₃ 2-F, 3-Cl—C₆H₃—CH₂557 O CH₃ 2-F, 4-Cl—C₆H₃—CH₂ 558 O CH₃ 2-F, 5-Cl—C₆H₃—CH₂ 559 O CH₃ 2-F,3-Br—C₆H₃—CH₂ 560 O CH₃ 2-F, 4-Br—C₆H₃—CH₂ 561 O CH₃ 2-F, 5-Br—C₆H₃—CH₂562 O CH₃ 2-Cl, 3-Br—C₆H₃—CH₂ 563 O CH₃ 2-Cl, 4-Br—C₆H₃—CH₂ 564 O CH₃2-Cl, 5-Br—C₆H₃—CH₂ 565 O CH₃ 3-F, 4-Cl—C₆H₃—CH₂ 566 O CH₃ 3-F,5-Cl—C₆H₃—CH₂ 567 O CH₃ 3-F, 6-Cl—C₆H₃—CH₂ 568 O CH₃ 3-F, 4-Br—C₆H₃—CH₂569 O CH₃ 3-F, 5-Br—C₆H₃—CH₂ 570 O CH₃ 3-F, 6-Br—C₆H₃—CH₂ 571 O CH₃3-Cl, 4-Br—C₆H₃—CH₂ 572 O CH₃ 3-Cl, 5-Br—C₆H₃—CH₂ 573 O CH₃ 3-Cl,6-Br—C₆H₃—CH₂ 574 O CH₃ 4-F, 5-Cl—C₆H₃—CH₂ 575 O CH₃ 4-F, 6-Cl—C₆H₃—CH₂576 O CH₃ 4-F, 5-Br—C₆H₃—CH₂ 577 O CH₃ 4-F, 6-Br—C₆H₃—CH₂ 578 O CH₃4-Cl, 5-Br—C₆H₃—CH₂ 579 O CH₃ 5-F, 6-Cl—C₆H₃—CH₂ 580 O CH₃ 5-F,6-Br—C₆H₃—CH₂ 581 O CH₃ 5-Cl, 6-Br—C₆H₃—CH₂ 582 O CH₃ 3-Br, 4-Cl,5-Br—C₆H₂—CH₂ 583 O CH₃ 2-CN—C₆H₄—CH₂ 584 O CH₃ 3-CN—C₆H₄—CH₂ 585 O CH₃4-CN—C₆H₄—CH₂ 586 O CH₃ 2-NO₂—C₆H₄—CH₂ 587 O CH₃ 3-NO₂—C₆H₄—CH₂ 588 OCH₃ 4-NO₂—C₆H₄—CH₂ 589 O CH₃ 2-CH₃—C₆H₄—CH₂ 590 O CH₃ 3-CH₃—C₆H₄—CH₂ 591O CH₃ 4-CH₃—C₆H₄—CH₂ 592 O CH₃ 2,3-(CH₃)₂—C₆H₃—CH₂ 593 O CH₃2,4-(CH₃)₂—C₆H₃—CH₂ 594 O CH₃ 2,5-(CH₃)₂—C₆H₃—CH₂ 595 O CH₃2,6-(CH₃)₂—C₆H₃—CH₂ 596 O CH₃ 3,4-(CH₃)₂—C₆H₃—CH₂ 597 O CH₃3,5-(CH₃)₂—C₆H₃—CH₂ 598 O CH₃ 2-C₂H₅—C₆H₄—CH₂ 599 O CH₃ 3-C₂H₅—C₆H₄—CH₂600 O CH₃ 4-C₂H₅—C₆H₄—CH₂ 601 O CH₃ 2-i-C₃H₇—C₆H₄—CH₂ 602 O CH₃3-i-C₃H₇—C₆H₄—CH₂ 603 O CH₃ 4-i-C₃H₇—C₆H₄—CH₂ 604 O CH₃2-cyclohexyl-C₆H₄—CH₂ 605 O CH₃ 3-cyclohexyl-C₆H₄—CH₂ 606 O CH₃4-cyclohexyl-C₆H₄—CH₂ 607 O CH₃ 2-vinyl-C₆H₄—CH₂ 608 O CH₃3-vinyl-C₆H₄—CH₂ 609 O CH₃ 4-vinyl-C₆H₄—CH₂ 610 O CH₃ 2-allyl-C₆H₄—CH₂611 O CH₃ 3-allyl-C₆H₄—CH₂ 612 O CH₃ 4-allyl-C₆H₄—CH₂ 613 O CH₃2-C₆H₅—C₆H₄—CH₂ 614 O CH₃ 3-C₆H₅—C₆H₄—CH₂ 615 O CH₃ 4-C₆H₅—C₆H₄—CH₂ 616O CH₃ 3-CH₃, 5-t-C₄H₉—C₆H₃—CH₂ 617 O CH₃ 2-OH—C₆H₄—CH₂ 618 O CH₃3-OH—C₆H₄—CH₂ 619 O CH₃ 4-OH—C₆H₄—CH₂ 620 O CH₃ 2-OCH₃—C₆H₄—CH₂ 621 OCH₃ 3-OCH₃—C₆H₄—CH₂ 622 O CH₃ 4-OCH₃—C₆H₄—CH₂ 623 O CH₃2-O-allyl-C₆H₄—CH₂ 624 O CH₃ 3-O-allyl-C₆H₄—CH₂ 625 O CH₃4-O-allyl-C₆H₄—CH₂ 626 O CH₃ 2-CF₃—C₆H₄—CH₂ 627 O CH₃ 3-CF₃—C₆H₄—CH₂ 628O CH₃ 4-CF₃—C₆H₄—CH₂ 629 O CH₃ 2-acetyl-C₆H₄—CH₂ 630 O CH₃3-acetyl-C₆H₄—CH₂ 631 O CH₃ 4-acetyl-C₆H₄—CH₂ 632 O CH₃2-methoxycarbonyl-C₆H₄—CH₂ 633 O CH₃ 3-methoxycarbonyl-C₆H₄—CH₂ 634 OCH₃ 4-methoxycarbonyl-C₆H₄—CH₂ 635 O CH₃ 2-aminocarbonyl-C₆H₄—CH₂ 636 OCH₃ 3-aminocarbonyl-C₆H₄—CH₂ 637 O CH₃ 4-aminocarbonyl-C₆H₄—CH₂ 638 OCH₃ 2-dimethylaminocarbonyl-C₆H₄—CH₂ 639 O CH₃3-dimethylaminocarbonyl-C₆H₄—CH₂ 640 O CH₃4-dimethylaminocarbonyl-C₆H₄—CH₂ 641 O CH₃2-(N-methylaminocarbonyl)-C₆H₄—CH₂ 642 O CH₃3-(N-methylaminocarbonyl)-C₆H₄—CH₂ 643 O CH₃4-(N-methylaminocarbonyl)-C₆H₄—CH₂ 644 O CH₃ 2-H₂N—C₆H₄—CH₂ 645 O CH₃3-H₂N—C₆H₄—CH₂ 646 O CH₃ 4-H₂N—C₆H₄—CH₂ 647 O CH₃2-aminothiocarbonyl-C₆H₄—CH₂ 648 O CH₃ 3-aminothiocarbonyl-C₆H₄—CH₂ 649O CH₃ 4-aminothiocarbonyl-C₆H₄—CH₂ 650 O CH₃ 2-SCH₃—C₆H₄—CH₂ 651 O CH₃3-SCH₃—C₆H₄—CH₂ 652 O CH₃ 4-SCH₃—C₆H₄—CH₂ 653 O CH₃ 2-SO₂CH₃—C₆H₄—CH₂654 O CH₃ 3-SO₂CH₃—C₆H₄—CH₂ 655 O CH₃ 4-SO₂CH₃—C₆H₄—CH₂ 656 O CH₃2-OCF₃—C₆H₄—CH₂ 657 O CH₃ 3-OCF₃—C₆H₄—CH₂ 658 O CH₃ 4-OCF₃—C₆H₄—CH₂ 659O CH₃ 2-OCHF₂—C₆H₄—CH₂ 660 O CH₃ 3-OCHF₂—C₆H₄—CH₂ 661 O CH₃4-OCHF₂—C₆H₄—CH₂ 662 O CH₃ 3-CF₃, 4-OCF₃—C₆H₃—CH₂ 663 O CH₃1-naphthyl-CH₂ 664 O CH₃ 2-naphthyl-CH₂ 665 O CH₃ 2-phenoxyeth-1-yl 666O CH₃ 2-(2′-chlorophenoxy)eth-1-yl 667 O CH₃2-(3′-chlorophenoxy)eth-1-yl 668 O CH₃ 2-(4′-chlorophenoxy)eth-1-yl 669O CH₃ 2-(3′,5′-dichlorophenoxy)eth-1-yl 670 O CH₃2-(4′-cyanophenoxy)eth-1-yl 671 O CH₃ 2-(3′-methylphenoxy)eth-1-yl 672 OCH₃ 2-(2′-nitrophenoxy)eth-1-yl 673 O CH₃ 3-phenoxyprop-1-yl 674 O CH₃3-(4′-chlorophenoxy)prop-1-yl 675 O CH₃ 3-(3′-cyanophenoxy)prop-1-yl 676O CH₃ 3-(2′-methylphenoxy)prop-1-yl 677 O CH₃ 4-phenoxybut-1-yl 678 OCH₃ 2-phenyleth-1-yl 679 O CH₃ 2-(4′-chlorophenyl)eth-1-yl 680 O CH₃2-(3′-cyanophenyl)eth-1-yl 1 O CH₃ 2-(2′-methylphenyl)eth-1-yl 2 O CH₃3-phenylprop-1-yl 3 O CH₃ 4-phenylbut-1-yl 4 O CH₃ 2-pyridylmethyl 5 OCH₃ 3-pyridylmethyl 6 O CH₃ 4-pyridylmethyl 7 O CH₃4-chloropyridin-2-ylmethyl 8 O CH₃ 5-chloropyridin-2-ylmethyl 9 O CH₃6-chloropyridin-2-ylmethyl 10 O CH₃ 5-chloropyridin-3-ylmethyl 11 O CH₃6-chloropyridin-3-ylmethyl 12 O CH₃ 2-chloropyridin-4-ylmethyl 13 O CH₃2-pyrimidinylmethyl 14 O CH₃ 4-chloropyrimidin-2-ylmethyl 15 O CH₃5-chloropyrimidin-2-ylmethyl 16 O CH₃ 2-chloropyrimidin-4-ylmethyl 17 OCH₃ 6-chloropyrimidin-4-ylmethyl 18 O CH₃ 2-chloropyrimidin-5-ylmethyl19 O CH₃ 4-pyridazinylmethyl 20 O CH₃ 2-pyrazinylmethyl 21 O CH₃5-chloropyrazin-2-ylmethyl 22 O CH₃ 6-chloropyrazin-2-ylmethyl 23 O CH₃3-pyridazinylmethyl 24 O CH₃ 6-chloropyridazin-3-ylmethyl 25 O CH₃1,3,5-triazinylmethyl 26 O CH₃ 2-furylmethyl 27 O CH₃ 3-furylmethyl 28 OCH₃ 4-bromofur-2-ylmethyl 29 O CH₃ 5-chlorofur-2-ylmethyl 30 O CH₃2-thienylmethyl 31 O CH₃ 3-thienylmethyl 32 O CH₃5-methylthien-3-ylmethyl 33 O CH₃ 5-chlorothien-2-ylmethyl 34 O CH₃2-chlorothien-4-ylmethyl 35 O CH₃ 2-pyrrolylmethyl 36 O CH₃3-pyrrolylmethyl 37 O CH₃ 2-oxazolylmethyl 38 O CH₃4-methyloxazol-2-ylmethyl 39 O CH₃ 5-methyloxazol-2-ylmethyl 40 O CH₃4-chlorooxazol-2-ylmethyl 41 O CH₃ 5-chlorooxazol-2-ylmethyl 42 O CH₃4-oxazolylmethyl 43 O CH₃ 2-methyloxazol-4-ylmethyl 44 O CH₃5-methyloxazol-4-ylmethyl 45 O CH₃ 2-chlorooxazol-4-ylmethyl 46 O CH₃5-chlorooxazol-4-ylmethyl 47 O CH₃ 5-oxazolylmethyl 48 O CH₃2-methyloxazol-5-ylmethyl 49 O CH₃ 4-methyloxazol-5-ylmethyl 50 O CH₃2-chlorooxazol-5-ylmethyl 51 O CH₃ 4-chlorooxazol-5-ylmethyl 52 O CH₃2-thiazolylmethyl 53 O CH₃ 4-methylthiazol-2-ylmethyl 54 O CH₃5-methylthiazol-2-ylmethyl 55 O CH₃ 4-chlorothiazol-2-ylmethyl 56 O CH₃5-chlorothiazol-2-ylmethyl 57 O CH₃ 4-thiazolylmethyl 58 O CH₃2-methylthiazol-4-ylmethyl 59 O CH₃ 5-methylthiazol-4-ylmethyl 60 O CH₃2-chlorothiazol-4-ylmethyl 61 O CH₃ 5-chlorothiazol-4-ylmethyl 62 O CH₃5-thiazolylmethyl 63 O CH₃ 2-methylthiazol-5-ylmethyl 64 O CH₃4-methylthiazol-5-ylmethyl 65 O CH₃ 2-chlorothiazol-5-ylmethyl 66 O CH₃4-chlorothiazol-5-ylmethyl 67 O CH₃ 3-isoxazolylmethyl 68 O CH₃4-methylisoxazol-3-ylmethyl 69 O CH₃ 5-methylisoxazol-3-ylmethyl 70 OCH₃ 4-chloroisoxazol-3-ylmethyl 71 O CH₃ 5-chloroisoxazol-3-ylmethyl 72O CH₃ 4-isoxazolylmethyl 73 O CH₃ 3-methylisoxazol-4-ylmethyl 74 O CH₃5-methylisoxazol-4-ylmethyl 75 O CH₃ 3-chloroisoxazol-4-ylmethyl 76 OCH₃ 5-chloroisoxazol-4-ylmethyl 77 O CH₃ 5-isoxazolylmethyl 78 O CH₃3-methylisoxazol-5-ylmethyl 79 O CH₃ 4-methylisoxazol-5-ylmethyl 80 OCH₃ 3-chloroisoxazol-5-ylmethyl 81 O CH₃ 4-chloroisoxazol-5-ylmethyl 82O CH₃ 3-isothiazolylmethyl 83 O CH₃ 4-methylisothiazol-3-ylmethyl 84 OCH₃ 5-methylisothiazol-3-ylmethyl 85 O CH₃ 4-chloroisothiazol-3-ylmethyl86 O CH₃ 5-chloroisothiazol-3-ylmethyl 87 O CH₃ 4-isothiazolylmethyl 88O CH₃ 3-methylisothiazol-4-ylmethyl 89 O CH₃5-methylisothiazol-4-ylmethyl 90 O CH₃ 3-chloroisothiazol-4-ylmethyl 91O CH₃ 5-chloroisothiazol-4-ylmethyl 92 O CH₃ 5-isothiazolylmethyl 93 OCH₃ 3-methylisothiazol-5-ylmethyl 94 O CH₃ 4-methylisothiazol-5-ylmethyl95 O CH₃ 3-chloroisothiazol-5-ylmethyl 96 O CH₃4-chloroisothiazol-5-ylmethyl 97 O CH₃ 4-imidazolylmethyl 98 O CH₃1-phenylpyrazol-3-ylmethyl 99 O CH₃ 1-methylimidazol-4-ylmethyl 100 OCH₃ 1-phenyl-1,2,4-triazol-3-ylmethyl 101 O CH₃1,2,4-oxadiazol-3-ylmethyl 102 O CH₃ 5-chloro-1,2,4-oxadiazol-3-ylmethyl103 O CH₃ 5-methyl-1,2,4-oxadiazol-3-ylmethyl 104 O CH₃5-trifluoromethyl-1,2,4-oxadiazol-3-ylmethyl 105 O CH₃1,3,4-oxadiazol-2-ylmethyl 106 O CH₃ 5-chloro-1,3,4-oxadiazol-2-ylmethyl107 O CH₃ 5-methyl-1,3,4-oxadiazol-2-ylmethyl 108 O CH₃5-methoxy-1,3,4-oxadiazol-2-ylmethyl 109 O CH₃1,2,4-thiadiazol-3-ylmethyl 110 O CH₃5-chloro-1,2,4-thiadiazol-3-ylmethyl 111 O CH₃5-methyl-1,2,4-thiadiazol-3-ylmethyl 112 O CH₃1,3,4-thiadiazol-2-ylmethyl 113 O CH₃5-chloro-1,3,4-thiadiazol-2-ylmethyl 114 O CH₃5-methyl-1,3,4-thiadiazol-2-ylmethyl 115 O CH₃5-cyano-1,3,4-thiadiazol-2-ylmethyl 116 O CH₃2-(2′-pyridinyloxy)eth-1-yl 117 O CH₃ 2-(3′-pyridinyloxy)eth-1-yl 118 OCH₃ 2-(4′-pyridinyloxy)eth-1-yl 119 O CH₃ C₆H₅ 120 O CH₃ 2-Cl—C₆H₄ 121 OCH₃ 3-Cl—C₆H₄ 122 O CH₃ 4-Cl—C₆H₄ 123 O CH₃ 2,3-Cl₂—C₆H₃ 124 O CH₃2,4-Cl₂—C₆H₃ 125 O CH₃ 2,5-Cl₂—C₆H₃ 126 O CH₃ 3,4-Cl₂—C₆H₃ 127 O CH₃3,5-Cl₂—C₆H₃ 128 O CH₃ 4-CN—C₆H₄ 129 O CH₃ 2-NO₂—C₆H₄ 130 O CH₃3-NO₂—C₆H₄ 131 O CH₃ 4-NO₂—C₆H₄ 132 O CH₃ 2,4-(NO₂)₂—C₆H₃ 133 O CH₃2-CH₃—C₆H₄ 134 O CH₃ 3-CH₃—C₆H₄ 135 O CH₃ 4-CH₃—C₆H₄ 136 O CH₃2,3-(CH₃)₂—C₆H₃ 137 O CH₃ 2,4-(CH₃)₂—C₆H₃ 138 O CH₃ 2,5-(CH₃)₂—C₆H₃ 139O CH₃ 2,6-(CH₃)₂—C₆H₃ 140 O CH₃ 2-C₆H₅—C₆H₄ 141 O CH₃ 3-C₆H₅—C₆H₄ 142 OCH₃ 4-C₆H₅—C₆H₄ 143 O CH₃ 3-OCH₃—C₆H₄ 144 O CH₃ 4-OCH₃—C₆H₄ 145 O CH₃3-acetyl-C₆H₄ 146 O CH₃ 4-acetyl-C₆H₄ 147 O CH₃ 3-methoxycarbonyl-C₆H₄148 O CH₃ 4-methoxycarbonyl-C₆H₄ 149 O CH₃ 3-CF₃—C₆H₄ 150 O CH₃4-CF₃—C₆H₄ 151 O CH₃ 2-naphthyl 152 O CH₃ 6-chloropyridazin-3-yl 153 OCH₃ 5-chloropyrazin-2-yl 154 O CH₃ quinolin-2-yl 155 O CH₃2,5-dimethylpyrazin-3-yl 156 O CH₃ pyrazin-2-yl 157 O CH₃3-chloropyrid-2-yl 158 O CH₃ 6-chloropyrid-2-yl 159 O CH₃4-trifluoromethyl, 6-chloropyrid-2-yl 160 O CH₃4-trifluoromethylpyrid-2-yl 161 O CH₃ 6-trifluoromethylpyrid-2-yl 162 OCH₃ 6-methoxypyrid-2-yl 163 O CH₃ 5-chloropyrid-2-yl 164 O CH₃pyrid-2-yl 165 O CH₃ benzothiazol-2-yl 166 O CH₃ 7-chloroquinolin-4-yl167 O CH₃ 3-nitropyrid-2-yl 168 O CH₃ pyrrol-3-yl 169 O CH₃ pyrrol-2-yl170 O CH₃ 2,6-dioctylpyrid-4-yl 171 O CH₃ 5-nitropyrid-2-yl 172 O CH₃pyrid-4-yl 173 O CH₃ pyrid-3-yl 174 O CH₃ pyrimidin-2-yl 175 O CH₃pyrimidin-4-yl 176 O CH₃ quinazolin-4-yl 177 O CH₃6-chloropyrimidin-4-yl 178 O CH₃ 6-methoxypyrimidin-4-yl 179 O CH₃2,5,6-trichloropyrimidin-4-yl 180 O CH₃ 2,6-dimethylpyrimidin-4-yl 181 OCH₃ 2-methyl, 6-chloropyrimidin-4-yl 182 O CH₃ 2-methyl,6-ethoxypyrimidin-4-yl 183 O CH₃ 4,5,6-trichloropyrimidin-2-yl 184 O CH₃4,6-dimethoxypyrimidin-2-yl 185 O CH₃ 4,6-dimethylpyrimidin-2-yl 186 OCH₃ 4,6-dichloropyrimidin-2-yl 187 O CH₃ 4-methyl,6-methoxypyrimidin-2-yl 188 O CH₃ 4-chloro, 6-methoxypyrimidin-2-yl 189O CH₃ 6-chloroquinoxalin-2-yl 190 O CH₃ 3,6-dichloro-1,2,4-triazin-5-yl191 O CH₃ 4-methoxy-1,3,5-triazin-2-yl 192 O CH₃4-ethoxy-1,3,5-triazin-2-yl 193 O CH₃ 4,6-dichloro-1,3,5-triazin-2-yl194 O CH₃ 4-ethoxy, 6-chloro-1,3,5-triazin-2-yl 195 O CH₃ isoxazol-3-yl196 O CH₃ thien-2-yl 197 O CH₃ fur-2-yl 198 O CH₃ thiatriazol-5-yl 199 OCH₃ (E)-1-chloropropen-3-yl 200 O CH₃(E)-4-(4′-chlorophenyl)but-2-en-1-yl 201 O CH₃ propyn-3-yl 202 O CH₃methylcarbonyl 203 O CH₃ 2-t-C₄H₉—C₆H₄—CH₂ 204 O CH₃ 3-t-C₄H₉—C₆H₄—CH₂205 O CH₃ 4-t-C₄H₉—C₆H₄—CH₂ 206 O CH₃2-(4′-chlorothiazol-2′-yloxy)eth-1-yl 207 O CH₃2-(1′-methylpyrazol-4′-yloxy)eth-1-yl 208 O CH₃ 4-Br—C₆H₄ 209 O CH₃3,5-(CH₃)₂—C₆H₃ 210 O CH₃ 4-C₂H₅—C₆H₄ 211 O CH₃3-dimethylaminocarbonyl-C₆H₄ 212 O CH₃ 4-dimethylaminocarbonyl-C₆H₄ 213O CH₃ 2-hydroxyprop-1-yl 214 O CH₃6-hydroxy-2-methylpyrimidin-4-ylmethyl 215 O CH₃[6-OH,2-CH(CH₃)₂-pyrimidin-4-yl]-CH₂ 216 O CH₃[6-OH,2-CH(CH₂)₂-pyrimidin-4-yl]-CH₂ 217 O CH₃ 5-(2′-furan)-pent-1-yl218 O CH₃ 5-(2′-N-methylpyrrole)-pent-1-yl 219 O CH₃[2-(4-Cl—C₆H₄)-oxazol-4-yl]-CH₂ 220 O CH₃ 3-CF₃-pyridin-2-yl 221 O CH₃5-CF₃-pyridin-2-yl 222 O CH₃ 6-(2′-thienyl)hex-1-yl 223 O C₂H₅ H 224 OC₂H₅ CH₃ 225 O C₂H₅ C₆H₅—CH₂ 226 O i-C₃H₇ CH₃ 227 NH H H 228 NH H CH₃229 NH H 4-Cl—C₆H₄—CH₂ 230 NH CH₃ CH₃ 231 NH CH₃ C₆H₅—CH₂ 232 NCH₃ CH₃CH₃ 233 NCH₃ CH₃ 4-CH₃—C₆H₄—CH₂ 234 S CH₃ H 235 S CH₃ CH₃ 236 S CH₃ C₂H₅237 S CH₃ C₆H₅—CH₂ 238 — C₂H₅ H 239 — C₂H₅ CH₃ 240 — C₂H₅ C₆H₅—CH₂ 241 —C₂H₅ 3-CN—C₆H₄—CH₂ 242 — C₂H₅ prop-2-en-1-yl 243 — n-C₃H₇ H 244 — n-C₃H₇CH₃ 245 — C₆H₅ H 246 — C₆H₅ CH₃ 247 — C₆H₅ 3-OCH₃—C₆H₄—CH₂ d) R⁴ =4-C(═NOR^(a))—Ap—R^(b) 1 — CH₃ H 2 — CH₃ CH₃ 3 — CH₃ C₂H₅ 4 — CH₃ n-C₃H₇5 — CH₃ i-C₃H₇ 6 — CH₃ cyclopropyl 7 — CH₃ n-C₄H₉ 8 — CH₃ s-C₄H₉ 9 — CH₃i-C₄H₉ 10 — CH₃ t-C₄H₉ 11 — CH₃ n-C₅H₁₁ 12 — CH₃ i-C₅H₁₁ 13 — CH₃neo-C₅H₁₁ 14 — CH₃ cyclopentyl 15 — CH₃ n-C₆H₁₃ 16 — CH₃ cyclohexyl 17 —CH₃ CH₂CH₂Cl 18 — CH₃ (CH₂)₄Cl 19 — CH₃ CH₂CN 20 — CH₃ CH₂CH₂CN 21 — CH₃(CH₂)₃CN 22 — CH₃ (CH₂)₄CN 23 — CH₃ (CH₂)₆CN 24 — CH₃ cyclohexylmethyl25 — CH₃ 2-cyclohexyleth-1-yl 26 — CH₃ cyclopropylmethyl 27 — CH₃2-cyclopropyleth-1-yl 28 — CH₃ 2-methoxyeth-1-yl 29 — CH₃2-ethoxyeth-1-yl 30 — CH₃ 2-isopropoxyeth-1-yl 31 — CH₃3-methoxyprop-1-yl 32 — CH₃ 3-ethoxyprop-1-yl 33 — CH₃3-isopropoxyprop-1-yl 34 — CH₃ 4-methoxybut-1-yl 35 — CH₃4-isopropoxybut-1-yl 36 — CH₃ propen-3-yl 37 — CH₃ but-2-en-1-yl 38 —CH₃ 3-methylbut-2-en-1-yl 39 — CH₃ 2-vinyloxyeth-1-yl 40 — CH₃allyloxyeth-1-yl 41 — CH₃ 2-trifluoromethoxyeth-1-yl 42 — CH₃3-trifluoromethoxyprop-1-yl 43 — CH₃ 4-difluoromethoxybut-1-yl 44 — CH₃hydroxycarbonylmethyl 45 — CH₃ methoxycarbonylmethyl 46 — CH₃aminocarbonylmethyl 47 — CH₃ N-methylaminocarbonylmethyl 48 — CH₃N,N-dimethylaminocarbonyl-methyl 49 — CH₃ 2-hydroxycarbonyleth-1-yl 50 —CH₃ 2-methoxycarbonyleth-1-yl 51 — CH₃ 2-aminocarbonyleth-1-yl 52 — CH₃2-N-methylaminocarbonyleth-1-yl 53 — CH₃ 2-dimethylaminocarbonyleth-1-yl54 — CH₃ 2-aminoeth-1-yl 55 — CH₃ 2-aminoprop-1-yl 56 — CH₃4-aminobut-1-yl 57 — CH₃ 3-dimethylaminoprop-1-yl 58 — CH₃4-aminothiocarbonylbut-1-yl 59 — CH₃ 6-aminocarbonylhex-1-yl 60 — CH₃3-aminothiocarbonylprop-1-yl 61 — CH₃ 2-aminothiocarbonyleth-1-yl 62 —CH₃ aminothiocarbonylmethyl 63 — CH₃ 4-(N,N-dimethylamino)but-1-yl 64 —CH₃ 2-(methylthio)eth-1-yl 65 — CH₃ 2-(methylsulfonyl)eth-1-yl 66 — CH₃4-(methylthio)prop-1-yl 67 — CH₃ 4-(methylsulfonyl)prop-1-yl 68 — CH₃benzyl 69 — CH₃ 2-F—C₆H₄—CH₂ 70 — CH₃ 3-F—C₆H₄—CH₂ 71 — CH₃ 4-F—C₆H₄—CH₂72 — CH₃ 2,3-F₂—C₆H₃—CH₂ 73 — CH₃ 2,4-F₂—C₆H₃—CH₂ 74 — CH₃2,5-F₂—C₆H₃—CH₂ 75 — CH₃ 2,6-F₂—C₆H₃—CH₂ 76 — CH₃ 3,4-F₂—C₆H₃—CH₂ 77 —CH₃ 3,5-F₂—C₆H₃—CH₂ 78 — CH₃ 2-Cl—C₆H₄—CH₂ 79 — CH₃ 3-Cl—C₆H₄—CH₂ 80 —CH₃ 4-Cl—C₆H₄—CH₂ 81 — CH₃ 2,3-Cl₂—C₆H₃—CH₂ 82 — CH₃ 2,4-Cl₂—C₆H₃—CH₂ 83— CH₃ 2,5-Cl₂—C₆H₃—CH₂ 84 — CH₃ 2,6-Cl₂—C₆H₃—CH₂ 85 — CH₃3,4-Cl₂—C₆H₃—CH₂ 86 — CH₃ 3,5-Cl₂—C₆H₃—CH₂ 87 — CH₃ 2,3,4-Cl₃—C₆H₂—CH₂88 — CH₃ 2,3,5-Cl₃—C₆H₂—CH₂ 89 — CH₃ 2,3,6-Cl₃—C₆H₂—CH₂ 90 — CH₃2,4,5-Cl₃—C₆H₂—CH₂ 91 — CH₃ 2,4,6-Cl₃—C₆H₂—CH₂ 92 — CH₃3,4,5-Cl₃—C₆H₂—CH₂ 93 — CH₃ 2-Br—C₆H₄—CH₂ 94 — CH₃ 3-Br—C₆H₄—CH₂ 95 —CH₃ 4-Br—C₆H₄—CH₂ 96 — CH₃ 2,3-Br₂—C₆H₃—CH₂ 97 — CH₃ 2,4-Br₂—C₆H₃—CH₂ 98— CH₃ 2,5-Br₂—C₆H₃—CH₂ 99 — CH₃ 2,6-Br₂—C₆H₃—CH₂ 100 — CH₃3,4-Br₂—C₆H₃—CH₂ 101 — CH₃ 3,5-Br₂—C₆H₃—CH₂ 102 — CH₃ 2-F, 3-Cl—C₆H₃—CH₂103 — CH₃ 2-F, 4-Cl—C₆H₃—CH₂ 104 — CH₃ 2-F, 5-Cl—C₆H₃—CH₂ 105 — CH₃ 2-F,3-Br—C₆H₃—CH₂ 106 — CH₃ 2-F, 4-Br—C₆H₃—CH₂ 107 — CH₃ 2-F, 5-Br—C₆H₃—CH₂108 — CH₃ 2-Cl, 3-Br—C₆H₃—CH₂ 109 — CH₃ 2-Cl, 4-Br—C₆H₃—CH₂ 110 — CH₃2-Cl, 5-Br—C₆H₃—CH₂ 111 — CH₃ 3-F, 4-Cl—C₆H₃—CH₂ 112 — CH₃ 3-F,5-Cl—C₆H₃—CH₂ 113 — CH₃ 3-F, 6-Cl—C₆H₃—CH₂ 114 — CH₃ 3-F, 4-Br—C₆H₃—CH₂115 — CH₃ 3-F, 5-Br—C₆H₃—CH₂ 116 — CH₃ 3-F, 6-Br—C₆H₃—CH₂ 117 — CH₃3-Cl, 4-Br—C₆H₃—CH₂ 118 — CH₃ 3-Cl, 5-Br—C₆H₃—CH₂ 119 — CH₃ 3-Cl,6-Br—C₆H₃—CH₂ 120 — CH₃ 4-F, 5-Cl—C₆H₃—CH₂ 121 — CH₃ 4-F, 6-Cl—C₆H₃—CH₂122 — CH₃ 4-F, 5-Br—C₆H₃—CH₂ 123 — CH₃ 4-F, 6-Br—C₆H₃—CH₂ 124 — CH₃4-Cl, 5-Br—C₆H₃—CH₂ 125 — CH₃ 5-F, 6-Cl—C₆H₃—CH₂ 126 — CH₃ 5-F,6-Br—C₆H₃—CH₂ 127 — CH₃ 5-Cl, 6-Br—C₆H₃—CH₂ 128 — CH₃ 3-Br, 4-Cl,5-Br—C₆H₂—CH₂ 129 — CH₃ 2-CN—C₆H₄—CH₂ 130 — CH₃ 3-CN—C₆H₄—CH₂ 131 — CH₃4-CN—C₆H₄—CH₂ 132 — CH₃ 2-NO₂—C₆H₄—CH₂ 133 — CH₃ 3-NO₂—C₆H₄—CH₂ 134 —CH₃ 4-NO₂—C₆H₄—CH₂ 135 — CH₃ 2-CH₃—C₆H₄—CH₂ 136 — CH₃ 3-CH₃—C₆H₄—CH₂ 137— CH₃ 4-CH₃—C₆H₄—CH₂ 138 — CH₃ 2,3-(CH₃)₂—C₆H₃—CH₂ 139 — CH₃2,4-(CH₃)₂—C₆H₃—CH₂ 140 — CH₃ 2,5-(CH₃)₂—C₆H₃—CH₂ 141 — CH₃2,6-(CH₃)₂—C₆H₃—CH₂ 142 — CH₃ 3,4-(CH₃)₂—C₆H₃—CH₂ 143 — CH₃3,5-(CH₃)₂—C₆H₃—CH₂ 144 — CH₃ 2-C₂H₅—C₆H₄—CH₂ 145 — CH₃ 3-C₂H₅—C₆H₄—CH₂146 — CH₃ 4-C₂H₅—C₆H₄—CH₂ 147 — CH₃ 2-i-C₃H₇—C₆H₄—CH₂ 148 — CH₃3-i-C₃H₇—C₆H₄—CH₂ 149 — CH₃ 4-i-C₃H₇—C₆H₄—CH₂ 150 — CH₃2-cyclohexyl-C₆H₄—CH₂ 151 — CH₃ 3-cyclohexyl-C₆H₄—CH₂ 152 — CH₃4-cyclohexyl-C₆H₄—CH₂ 153 — CH₃ 2-vinyl-C₆H₄—CH₂ 154 — CH₃3-vinyl-C₆H₄—CH₂ 155 — CH₃ 4-vinyl-C₆H₄—CH₂ 156 — CH₃ 2-allyl-C₆H₄—CH₂157 — CH₃ 3-allyl-C₆H₄—CH₂ 158 — CH₃ 4-allyl-C₆H₄—CH₂ 159 — CH₃2-C₆H₅—C₆H₄—CH₂ 160 — CH₃ 3-C₆H₅—C₆H₄—CH₂ 161 — CH₃ 4-C₆H₅—C₆H₄—CH₂ 162— CH₃ 3-CH₃, 5-t-C₄H₉—C₆H₃—CH₂ 163 — CH₃ 2-OH—C₆H₄—CH₂ 164 — CH₃3-OH—C₆H₄—CH₂ 165 — CH₃ 4-OH—C₆H₄—CH₂ 166 — CH₃ 2-OCH₃—C₆H₄—CH₂ 167 —CH₃ 3-OCH₃—C₆H₄—CH₂ 168 — CH₃ 4-OCH₃—C₆H₄—CH₂ 169 — CH₃2-O-allyl-C₆H₄—CH₂ 170 — CH₃ 3-O-allyl-C₆H₄—CH₂ 171 — CH₃4-O-allyl-C₆H₄—CH₂ 172 — CH₃ 2-CF₃—C₆H₄—CH₂ 173 — CH₃ 3-CF₃—C₆H₄—CH₂ 174— CH₃ 4-CF₃—C₆H₄—CH₂ 175 — CH₃ 2-acetyl-C₆H₄—CH₂ 176 — CH₃3-acetyl-C₆H₄—CH₂ 177 — CH₃ 4-acetyl-C₆H₄—CH₂ 178 — CH₃2-methoxycarbonyl-C₆H₄—CH₂ 179 — CH₃ 3-methoxycarbonyl-C₆H₄—CH₂ 180 —CH₃ 4-methoxycarbonyl-C₆H₄—CH₂ 181 — CH₃ 2-aminocarbonyl-C₆H₄—CH₂ 182 —CH₃ 3-aminocarbonyl-C₆H₄—CH₂ 183 — CH₃ 4-aminocarbonyl-C₆H₄—CH₂ 184 —CH₃ 2-dimethylaminocarbonyl-C₆H₄—CH₂ 185 — CH₃3-dimethylaminocarbonyl-C₆H₄—CH₂ 186 — CH₃4-dimethylaminocarbonyl-C₆H₄—CH₂ 187 — CH₃2-(N-methylaminocarbonyl)-C₆H₄—CH₂ 188 — CH₃3-(N-methylaminocarbonyl)-C₆H₄—CH₂ 189 — CH₃4-(N-methylaminocarbonyl)-C₆H₄—CH₂ 190 — CH₃ 2-H₂N—C₆H₄—CH₂ 191 — CH₃3-H₂N—C₆H₄—CH₂ 192 — CH₃ 4-H₂N—C₆H₄—CH₂ 193 — CH₃2-aminothiocarbonyl-C₆H₄—CH₂ 194 — CH₃ 3-aminothiocarbonyl-C₆H₄—CH₂ 195— CH₃ 4-aminothiocarbonyl-C₆H₄—CH₂ 196 — CH₃ 2-SCH₃—C₆H₄—CH₂ 197 — CH₃3-SCH₃—C₆H₄—CH₂ 198 — CH₃ 4-SCH₃—C₆H₄—CH₂ 199 — CH₃ 2-SO₂CH₃—C₆H₄—CH₂200 — CH₃ 3-SO₂CH₃—C₆H₄—CH₂ 201 — CH₃ 4-SO₂CH₃—C₆H₄—CH₂ 202 — CH₃2-OCF₃—C₆H₄—CH₂ 203 — CH₃ 3-OCF₃—C₆H₄—CH₂ 204 — CH₃ 4-OCF₃—C₆H₄—CH₂ 205— CH₃ 2-OCHF₂—C₆H₄—CH₂ 206 — CH₃ 3-OCHF₂—C₆H₄—CH₂ 207 — CH₃4-OCHF₂—C₆H₄—CH₂ 208 — CH₃ 3-CF₃, 4-OCF₃—C₆H₃—CH₂ 209 — CH₃1-naphthyl-CH₂ 210 — CH₃ 2-naphthyl-CH₂ 211 — CH₃ 2-phenoxyeth-1-yl 212— CH₃ 2-(2′-chlorophenoxy)eth-1-yl 213 — CH₃2-(3′-chlorophenoxy)eth-1-yl 214 — CH₃ 2-(4′-chlorophenoxy)eth-1-yl 215— CH₃ 2-(3′,5′-dichlorophenoxy)eth-1-yl 216 — CH₃2-(4′-cyanophenoxy)eth-1-yl 217 — CH₃ 2-(3′-methylphenoxy)eth-1-yl 218 —CH₃ 2-(2′-nitrophenoxy)eth-1-yl 219 — CH₃ 3-phenoxyprop-1-yl 220 — CH₃3-(4′-chlorophenoxy)prop-1-yl 221 — CH₃ 3-(3′-cyanophenoxy)prop-1-yl 222— CH₃ 3-(2′-methylphenoxy)prop-1-yl 223 — CH₃ 4-phenoxybut-1-yl 224 —CH₃ 2-phenyleth-1-yl 225 — CH₃ 2-(4′-chlorophenyl)eth-1-yl 226 — CH₃2-(3′-cyanophenyl)eth-1-yl 227 — CH₃ 2-(2′-methylphenyl)eth-1-yl 228 —CH₃ 3-phenylprop-1-yl 229 — CH₃ 4-phenylbut-1-yl 230 — CH₃2-pyridylmethyl 231 — CH₃ 3-pyridylmethyl 232 — CH₃ 4-pyridylmethyl 233— CH₃ 4-chloropyridin-2-ylmethyl 234 — CH₃ 5-chloropyridin-2-ylmethyl235 — CH₃ 6-chloropyridin-2-ylmethyl 236 — CH₃5-chloropyridin-3-ylmethyl 237 — CH₃ 6-chloropyridin-3-ylmethyl 238 —CH₃ 2-chloropyridin-4-ylmethyl 239 — CH₃ 2-pyrimidinylmethyl 240 — CH₃4-chloropyrimidin-2-ylmethyl 241 — CH₃ 5-chloropyrimidin-2-ylmethyl 242— CH₃ 2-chloropyrimidin-4-ylmethyl 243 — CH₃6-chloropyrimidin-4-ylmethyl 244 — CH₃ 2-chloropyrimidin-5-ylmethyl 245— CH₃ 4-pyridazinylmethyl 246 — CH₃ 2-pyrazinylmethyl 247 — CH₃5-chloropyrazin-2-ylmethyl 248 — CH₃ 6-chloropyrazin-2-ylmethyl 249 —CH₃ 3-pyridazinylmethyl 250 — CH₃ 6-chloropyridazin-3-ylmethyl 251 — CH₃1,3,5-triazinylmethyl 252 — CH₃ 2-furylmethyl 253 — CH₃ 3-furylmethyl254 — CH₃ 4-bromofur-2-ylmethyl 255 — CH₃ 5-chlorofur-2-ylmethyl 256 —CH₃ 2-thienylmethyl 257 — CH₃ 3-thienylmethyl 258 — CH₃5-methylthien-3-ylmethyl 259 — CH₃ 5-chlorothien-2-ylmethyl 260 — CH₃2-chlorothien-4-ylmethyl 261 — CH₃ 2-pyrrolylmethyl 262 — CH₃3-pyrrolylmethyl 263 — CH₃ 2-oxazolylmethyl 264 — CH₃4-methyloxazol-2-ylmethyl 265 — CH₃ 5-methyloxazol-2-ylmethyl 266 — CH₃4-chlorooxazol-2-ylmethyl 267 — CH₃ 5-chlorooxazol-2-ylmethyl 268 — CH₃4-oxazolylmethyl 269 — CH₃ 2-methyloxazol-4-ylmethyl 270 — CH₃5-methyloxazol-4-ylmethyl 271 — CH₃ 2-chlorooxazol-4-ylmethyl 272 — CH₃5-chlorooxazol-4-ylmethyl 273 — CH₃ 5-oxazolylmethyl 274 — CH₃2-methyloxazol-5-ylmethyl 275 — CH₃ 4-methyloxazol-5-ylmethyl 276 — CH₃2-chlorooxazol-5-ylmethyl 277 — CH₃ 4-chlorooxazol-5-ylmethyl 278 — CH₃2-thiazolylmethyl 279 — CH₃ 4-methylthiazol-2-ylmethyl 280 — CH₃5-methylthiazol-2-ylmethyl 281 — CH₃ 4-chlorothiazol-2-ylmethyl 282 —CH₃ 5-chlorothiazol-2-ylmethyl 283 — CH₃ 4-thiazolylmethyl 284 — CH₃2-methylthiazol-4-ylmethyl 285 — CH₃ 5-methylthiazol-4-ylmethyl 286 —CH₃ 2-chlorothiazol-4-ylmethyl 287 — CH₃ 5-chlorothiazol-4-ylmethyl 288— CH₃ 5-thiazolylmethyl 289 — CH₃ 2-methylthiazol-5-ylmethyl 290 — CH₃4-methylthiazol-5-ylmethyl 291 — CH₃ 2-chlorothiazol-5-ylmethyl 292 —CH₃ 4-chlorothiazol-5-ylmethyl 293 — CH₃ 3-isoxazolylmethyl 294 — CH₃4-methylisoxazol-3-ylmethyl 295 — CH₃ 5-methylisoxazol-3-ylmethyl 296 —CH₃ 4-chloroisoxazol-3-ylmethyl 297 — CH₃ 5-chloroisoxazol-3-ylmethyl298 — CH₃ 4-isoxazolylmethyl 299 — CH₃ 3-methylisoxazol-4-ylmethyl 300 —CH₃ 5-methylisoxazol-4-ylmethyl 301 — CH₃ 3-chloroisoxazol-4-ylmethyl302 — CH₃ 5-chloroisoxazol-4-ylmethyl 303 — CH₃ 5-isoxazolylmethyl 304 —CH₃ 3-methylisoxazol-5-ylmethyl 305 — CH₃ 4-methylisoxazol-5-ylmethyl306 — CH₃ 3-chloroisoxazol-5-ylmethyl 307 — CH₃4-chloroisoxazol-5-ylmethyl 308 — CH₃ 3-isothiazolylmethyl 309 — CH₃4-methylisothiazol-3-ylmethyl 310 — CH₃ 5-methylisothiazol-3-ylmethyl311 — CH₃ 4-chloroisothiazol-3-ylmethyl 312 — CH₃5-chloroisothiazol-3-ylmethyl 313 — CH₃ 4-isothiazolylmethyl 314 — CH₃3-methylisothiazol-4-ylmethyl 315 — CH₃ 5-methylisothiazol-4-ylmethyl316 — CH₃ 3-chloroisothiazol-4-ylmethyl 317 — CH₃5-chloroisothiazol-4-ylmethyl 318 — CH₃ 5-isothiazolylmethyl 319 — CH₃3-methylisothiazol-5-ylmethyl 320 — CH₃ 4-methylisothiazol-5-ylmethyl321 — CH₃ 3-chloroisothiazol-5-ylmethyl 322 — CH₃4-chloroisothiazol-5-ylmethyl 323 — CH₃ 4-imidazolylmethyl 324 — CH₃1-phenylpyrazol-3-ylmethyl 325 — CH₃ 1-methylimidazol-4-ylmethyl 326 —CH₃ 1-phenyl-1,2,4-triazol-3-ylmethyl 327 — CH₃1,2,4-oxadiazol-3-ylmethyl 328 — CH₃ 5-chloro-1,2,4-oxadiazol-3-ylmethyl329 — CH₃ 5-methyl-1,2,4-oxadiazol-3-ylmethyl 330 — CH₃5-trifluoromethyl-1,2,4-oxadiazol-3-ylmethyl 331 — CH₃1,3,4-oxadiazol-2-ylmethyl 332 — CH₃ 5-chloro-1,3,4-oxadiazol-2-ylmethyl333 — CH₃ 5-methyl-1,3,4-oxadiazol-2-ylmethyl 334 — CH₃5-methoxy-1,3,4-oxadiazol-2-ylmethyl 335 — CH₃1,2,4-thiadiazol-3-ylmethyl 336 — CH₃5-chloro-1,2,4-thiadiazol-3-ylmethyl 337 — CH₃5-methyl-1,2,4-thiadiazol-3-ylmethyl 338 — CH₃1,3,4-thiadiazol-2-ylmethyl 339 — CH₃5-chloro-1,3,4-thiadiazol-2-ylmethyl 340 — CH₃5-methyl-1,3,4-thiadiazol-2-ylmethyl 341 — CH₃5-cyano-1,3,4-thiadiazol-2-ylmethyl 342 — CH₃2-(2′-pyridinyloxy)eth-1-yl 343 — CH₃ 2-(3′-pyridinyloxy)eth-1-yl 344 —CH₃ 2-(4′-pyridinyloxy)eth-1-yl 345 — CH₃ C₆H₅ 346 — CH₃ 2-Cl—C₆H₄ 347 —CH₃ 3-Cl—C₆H₄ 348 — CH₃ 4-Cl—C₆H₄ 349 — CH₃ 2,3-Cl₂—C₆H₃ 350 — CH₃2,4-Cl₂—C₆H₃ 351 — CH₃ 2,5-Cl₂—C₆H₃ 352 — CH₃ 3,4-Cl₂—C₆H₃ 353 — CH₃3,5-Cl₂—C₆H₃ 354 — CH₃ 4-CN—C₆H₄ 355 — CH₃ 2-NO₂—C₆H₄ 356 — CH₃3-NO₂—C₆H₄ 357 — CH₃ 4-NO₂—C₆H₄ 358 — CH₃ 2,4-(NO₂)₂—C₆H₃ 359 — CH₃2-CH₃—C₆H₄ 360 — CH₃ 3-CH₃—C₆H₄ 361 — CH₃ 4-CH₃—C₆H₄ 362 — CH₃2,3-(CH₃)₂—C₆H₃ 363 — CH₃ 2,4-(CH₃)₂—C₆H₃ 364 — CH₃ 2,5-(CH₃)₂—C₆H₃ 365— CH₃ 2,6-(CH₃)₂—C₆H₃ 366 — CH₃ 2-C₆H₅—C₆H₄ 367 — CH₃ 3-C₆H₅—C₆H₄ 368 —CH₃ 4-C₆H₅—C₆H₄ 369 — CH₃ 3-OCH₃—C₆H₄ 370 — CH₃ 4-OCH₃—C₆H₄ 371 — CH₃3-acetyl-C₆H₄ 372 — CH₃ 4-acetyl-C₆H₄ 373 — CH₃ 3-methoxycarbonyl-C₆H₄374 — CH₃ 4-methoxycarbonyl-C₆H₄ 375 — CH₃ 3-CF₃—C₆H₄ 376 — CH₃4-CF₃—C₆H₄ 377 — CH₃ 2-naphthyl 378 — CH₃ 6-chloropyridazin-3-yl 379 —CH₃ 5-chloropyrazin-2-yl 380 — CH₃ quinolin-2-yl 381 — CH₃2,5-dimethylpyrazin-3-yl 382 — CH₃ pyrazin-2-yl 383 — CH₃3-chloropyrid-2-yl 384 — CH₃ 6-chloropyrid-2-yl 385 — CH₃4-trifluoromethyl, 6-chloropyrid-2-yl 386 — CH₃4-trifluoromethylpyrid-2-yl 387 — CH₃ 6-trifluoromethylpyrid-2-yl 388 —CH₃ 6-methoxypyrid-2-yl 389 — CH₃ 5-chloropyrid-2-yl 390 — CH₃pyrid-2-yl 391 — CH₃ benzothiazol-2-yl 392 — CH₃ 7-chloroquinolin-4-yl393 — CH₃ 3-nitropyrid-2-yl 394 — CH₃ pyrrol-3-yl 395 — CH₃ pyrrol-2-yl396 — CH₃ 2,6-dioctylpyrid-4-yl 397 — CH₃ 5-nitropyrid-2-yl 398 — CH₃pyrid-4-yl 399 — CH₃ pyrid-3-yl 400 — CH₃ pyrimidin-2-yl 401 — CH₃pyrimidin-4-yl 402 — CH₃ quinazolin-4-yl 403 — CH₃6-chloropyrimidin-4-yl 404 — CH₃ 6-methoxypyrimidin-4-yl 405 — CH₃2,5,6-trichloropyrimidin-4-yl 406 — CH₃ 2,6-dimethylpyrimidin-4-yl 407 —CH₃ 2-methyl, 6-chloropyrimidin-4-yl 408 — CH₃ 2-methyl,6-ethoxypyrimidin-4-yl 409 — CH₃ 4,5,6-trichloropyrimidin-2-yl 410 — CH₃4,6-dimethoxypyrimidin-2-yl 411 — CH₃ 4,6-dimethylpyrimidin-2-yl 412 —CH₃ 4,6-dichloropyrimidin-2-yl 413 — CH₃ 4-methyl,6-methoxypyrimidin-2-yl 414 — CH₃ 4-chloro, 6-methoxypyrimidin-2-yl 415— CH₃ 6-chloroquinoxalin-2-yl 416 — CH₃ 3,6-dichloro-1,2,4-triazin-5-yl417 — CH₃ 4-methoxy-1,3,5-triazin-2-yl 418 — CH₃4-ethoxy-1,3,5-triazin-2-yl 419 — CH₃ 4,6-dichloro-1,3,5-triazin-2-yl420 — CH₃ 4-ethoxy, 6-chloro-1,3,5-triazin-2-yl 421 — CH₃ isoxazol-3-yl422 — CH₃ thien-2-yl 423 — CH₃ fur-2-yl 424 — CH₃ thiatriazol-5-yl 425 —CH₃ (E)-1-chloropropen-3-yl 426 — CH₃(E)-4-(4′-chlorophenyl)but-2-en-1-yl 427 — CH₃ propyn-3-yl 428 — CH₃methylcarbonyl 429 — CH₃ 2-t-C₄H₉—C₆H₄—CH₂ 430 — CH₃ 3-t-C₄H₉—C₆H₄—CH₂431 — CH₃ 4-t-C₄H₉—C₆H₄—CH₂ 432 — CH₃2-(4′-chlorothiazol-2′-yloxy)eth-1-yl 433 — CH₃2-(1′-methylpyrazol-4′-yloxy)eth-1-yl 434 — CH₃ 4-Br—C₆H₄ 435 — CH₃3,5-(CH₃)₂—C₆H₃ 436 — CH₃ 4-C₂H₅—C₆H₄ 437 — CH₃3-dimethylaminocarbonyl-C₆H₄ 438 — CH₃ 4-dimethylaminocarbonyl-C₆H₄ 439— CH₃ 2-hydroxyprop-1-yl 440 — CH₃6-hydroxy-2-methylpyrimidin-4-ylmethyl 441 — CH₃[6-OH,2-CH(CH₃)₂-pyrimidin-4-yl]-CH₂ 442 — CH₃[6-OH,2-CH(CH₂)₂-pyrimidin-4-yl]-CH₂ 443 — CH₃ 5-(2′-furan)-pent-1-yl444 — CH₃ 5-(2′-N-methylpyrrole)-pent-1-yl 445 — CH₃[2-(4-Cl—C₆H₄)-oxazol-4-yl]-CH₂ 446 — CH₃ 3-CF₃-pyridin-2-yl 447 — CH₃5-CF₃-pyridin-2-yl 448 — CH₃ 6-(2′-thienyl)hex-1-yl 449 — H H 450 — HCH₃ 451 — H C₂H₅ 452 — H n-C₃H₇ 453 — H i-C₃H₇ 454 — H cyclopropyl 455 —H n-C₄H₉ 456 — H s-C₄H₉ 457 — H i-C₄H₉ 458 — H t-C₄H₉ 459 — H n-C₅H₁₁460 H i-C₅H₁₁ 461 — H neo-C₅H₁₁ 462 — H cyclopentyl 463 — H n-C₆H₁₃ 464— H cyclohexyl 465 — H CH₂CH₂Cl 466 — H (CH₂)₄Cl 467 — H CH₂CN 468 — HCH₂CH₂CN 469 — H (CH₂)₃CN 470 — H (CH₂₎ ₄CN 471 — H (CH₂)₆CN 472 — Hcyclohexylmethyl 473 — H 2-cyclohexyleth-1-yl 474 — H cyclopropylmethyl475 — H 2-cyclopropyleth-1-yl 476 — H 2-methoxyeth-1-yl 477 — H2-ethoxyeth-1-yl 478 — H 2-isopropoxyeth-1-yl 479 — H 3-methoxyprop-1-yl480 — H 3-ethoxyprop-1-yl 481 — H 3-isopropoxyprop-1-yl 482 — H4-methoxybut-1-yl 483 — H 4-isopropoxybut-1-yl 484 — H propen-3-yl 485 —H but-2-en-1-yl 486 — H 3-methylbut-2-en-1-yl 487 — H 2-vinyloxyeth-1-yl488 — H allyloxyeth-1-yl 489 — H 2-trifluoromethoxyeth-1-yl 490 — H3-trifluoromethoxyprop-1-yl 491 — H 4-difluoromethoxybut-1-yl 492 — Hhydroxycarbonylmethyl 493 — H methoxycarbonylmethyl 494 — Haminocarbonylmethyl 495 — H N-methylaminocarbonylmethyl 496 — HN,N-dimethylaminocarbonyl-methyl 497 — H 2-hydroxycarbonyleth-1-yl 498 —H 2-methoxycarbonyleth-1-yl 499 — H 2-aminocarbonyleth-1-yl 500 — H2-N-methylaminocarbonyleth-1-yl 501 — H 2-dimethylaminocarbonyleth-1-yl502 — H 2-aminoeth-1-yl 503 — H 2-aminoprop-1-yl 504 — H 4-aminobut-1-yl505 — H 3-dimethylaminoprop-1-yl 506 — H 4-aminothiocarbonylbut-1-yl 507— H 6-aminocarbonylhex-1-yl 508 — H 3-aminothiocarbonylprop-1-yl 509 — H2-aminothiocarbonyleth-1-yl 510 — H aminothiocarbonylmethyl 511 — H4-(N,N-dimethylamino)but-1-yl 512 — H 2-(methylthio)eth-1-yl 513 — H2-(methylsulfonyl)eth-1-yl 514 — H 4-(methylthio)prop-1-yl 515 — H4-(methylsulfonyl)prop-1-yl 516 — H benzyl 517 — H 2-F—C₆H₄—CH₂ 518 — H3-F—C₆H₄—CH₂ 519 — H 4-F—C₆H₄—CH₂ 520 — H 2,3-F₂—C₆H₃—CH₂ 521 — H2,4-F₂—C₆H₃—CH₂ 522 — H 2,5-F₂—C₆H₃—CH₂ 523 — H 2,6-F₂—C₆H₃—CH₂ 524 — H3,4-F₂—C₆H₃—CH₂ 525 — H 3,5-F₂—C₆H₃—CH₂ 526 — H 2-Cl—C₆H₄—CH₂ 527 — H3-Cl—C₆H₄—CH₂ 528 — H 4-Cl—C₆H₄—CH₂ 529 — H 2,3-Cl₂—C₆H₃—CH₂ 530 — H2,4-Cl₂—C₆H₃—CH₂ 531 — H 2,5-Cl₂—C₆H₃—CH₂ 532 — H 2,6-Cl₂—C₆H₃—CH₂ 533 —H 3,4-Cl₂—C₆H₃—CH₂ 534 — H 3,5-Cl₂—C₆H₃—CH₂ 535 — H 2,3,4-Cl₃—C₆H₂—CH₂536 — H 2,3,5-Cl₃—C₆H₂—CH₂ 537 — H 2,3,6-Cl₃—C₆H₂—CH₂ 538 — H2,4,5-Cl₃—C₆H₂—CH₂ 539 — H 2,4,6-Cl₃—C₆H₂—CH₂ 540 — H 3,4,5-Cl₃—C₆H₂—CH₂541 — H 2-Br—C₆H₄—CH₂ 542 — H 3-Br—C₆H₄—CH₂ 543 — H 4-Br—C₆H₄—CH₂ 544 —H 2,3-Br₂—C₆H₃—CH₂ 545 — H 2,4-Br₂—C₆H₃—CH₂ 546 — H 2,5-Br₂—C₆H₃—CH₂ 547— H 2,6-Br₂—C₆H₃—CH₂ 548 — H 3,4-Br₂—C₆H₃—CH₂ 549 — H 3,5-Br₂—C₆H₃—CH₂550 — H 2-F, 3-Cl—C₆H₃—CH₂ 551 — H 2-F, 4-Cl—C₆H₃—CH₂ 552 — H 2-F,5-Cl—C₆H₃—CH₂ 553 — H 2-F, 3-Br—C₆H₃—CH₂ 554 — H 2-F, 4-Br—C₆H₃—CH₂ 555— H 2-F, 5-Br—C₆H₃—CH₂ 556 — H 2-Cl, 3-Br—C₆H₃—CH₂ 557 — H 2-Cl,4-Br—C₆H₃—CH₂ 558 — H 2-Cl, 5-Br—C₆H₃—CH₂ 559 — H 3-F, 4-Cl—C₆H₃—CH₂ 560— H 3-F, 5-Cl—C₆H₃—CH₂ 561 — H 3-F, 6-Cl—C₆H₃—CH₂ 562 — H 3-F,4-Br—C₆H₃—CH₂ 563 — H 3-F, 5-Br—C₆H₃—CH₂ 564 — H 3-F, 6-Br—C₆H₃—CH₂ 565— H 3-Cl, 4-Br—C₆H₃—CH₂ 566 — H 3-Cl, 5-Br—C₆H₃—CH₂ 567 — H 3-Cl,6-Br—C₆H₃—CH₂ 568 — H 4-F, 5-Cl—C₆H₃—CH₂ 569 — H 4-F, 6-Cl—C₆H₃—CH₂ 570— H 4-F, 5-Br—C₆H₃—CH₂ 571 — H 4-F, 6-Br—C₆H₃—CH₂ 572 — H 4-Cl,5-Br—C₆H₃—CH₂ 573 — H 5-F, 6-Cl—C₆H₃—CH₂ 574 — H 5-F, 6-Br—C₆H₃—CH₂ 575— H 5-Cl, 6-Br—C₆H₃—CH₂ 576 — H 3-Br, 4-Cl, 5-Br—C₆H₂—CH₂ 577 — H2-CN—C₆H₄—CH₂ 578 — H 3-CN—C₆H₄—CH₂ 579 — H 4-CN—C₆H₄—CH₂ 580 — H2-NO₂—C₆H₄—CH₂ 581 — H 3-NO₂—C₆H₄—CH₂ 582 — H 4-NO₂—C₆H₄—CH₂ 583 — H2-CH₃—C₆H₄—CH₂ 584 — H 3-CH₃—C₆H₄—CH₂ 585 — H 4-CH₃—C₆H₄—CH₂ 586 — H2,3-(CH₃)₂—C₆H₃—CH₂ 587 — H 2,4-(CH₃)₂—C₆H₃—CH₂ 588 — H2,5-(CH₃)₂—C₆H₃—CH₂ 589 — H 2,6-(CH₃)₂—C₆H₃—CH₂ 590 — H3,4-(CH₃)₂—C₆H₃—CH₂ 591 — H 3,5-(CH₃)₂—C₆H₃—CH₂ 592 — H 2-C₂H₅—C₆H₄—CH₂593 — H 3-C₂H₅—C₆H₄—CH₂ 594 — H 4-C₂H₅—C₆H₄—CH₂ 595 — H2-i-C₃H₇—C₆H₄—CH₂ 596 — H 3-i-C₃H₇—C₆H₄—CH₂ 597 — H 4-i-C₃H₇—C₆H₄—CH₂598 — H 2-cyclohexyl-C₆H₄—CH₂ 599 — H 3-cyclohexyl-C₆H₄—CH₂ 600 — H4-cyclohexyl-C₆H₄—CH₂ 601 — H 2-vinyl-C₆H₄—CH₂ 602 — H 3-vinyl-C₆H₄—CH₂603 — H 4-vinyl-C₆H₄—CH₂ 604 — H 2-allyl-C₆H₄—CH₂ 605 — H3-allyl-C₆H₄—CH₂ 606 — H 4-allyl-C₆H₄—CH₂ 607 — H 2-C₆H₅—C₆H₄—CH₂ 608 —H 3-C₆H₅—C₆H₄—CH₂ 609 — H 4-C₆H₅—C₆H₄—CH₂ 610 — H 3-CH₃,5-t-C₄H₉—C₆H₃—CH₂ 611 — H 2-OH—C₆H₄—CH₂ 612 — H 3-OH—C₆H₄—CH₂ 613 — H4-OH—C₆H₄—CH₂ 614 — H 2-OCH₃—C₆H₄—CH₂ 615 — H 3-OCH₃—C₆H₄—CH₂ 616 — H4-OCH₃—C₆H₄—CH₂ 617 — H 2-O-allyl-C₆H₄—CH₂ 618 — H 3-O-allyl-C₆H₄—CH₂619 — H 4-O-allyl-C₆H₄—CH₂ 620 — H 2-CF₃—C₆H₄—CH₂ 621 — H 3-CF₃—C₆H₄—CH₂622 — H 4-CF₃—C₆H₄—CH₂ 623 — H 2-acetyl-C₆H₄—CH₂ 624 — H3-acetyl-C₆H₄—CH₂ 625 — H 4-acetyl-C₆H₄—CH₂ 626 — H2-methoxycarbonyl-C₆H₄—CH₂ 627 — H 3-methoxycarbonyl-C₆H₄—CH₂ 628 — H4-methoxycarbonyl-C₆H₄—CH₂ 629 — H 2-aminocarbonyl-C₆H₄—CH₂ 630 — H3-aminocarbonyl-C₆H₄—CH₂ 631 — H 4-aminocarbonyl-C₆H₄—CH₂ 632 — H2-dimethylaminocarbonyl-C₆H₄—CH₂ 633 — H3-dimethylaminocarbonyl-C₆H₄—CH₂ 634 — H4-dimethylaminocarbonyl-C₆H₄—CH₂ 635 — H2-(N-methylaminocarbonyl)-C₆H₄—CH₂ 636 — H3-(N-methylaminocarbonyl)-C₆H₄—CH₂ 637 — H4-(N-methylaminocarbonyl)-C₆H₄—CH₂ 638 — H 2-H₂N—C₆H₄—CH₂ 639 — H3-H₂N—C₆H₄—CH₂ 640 — H 4-H₂N—C₆H₄—CH₂ 641 — H2-aminothiocarbonyl-C₆H₄—CH₂ 642 — H 3-aminothiocarbonyl-C₆H₄—CH₂ 643 —H 4-aminothiocarbonyl-C₆H₄—CH₂ 644 — H 2-SCH₃—C₆H₄—CH₂ 645 — H3-SCH₃—C₆H₄—CH₂ 646 — H 4-SCH₃—C₆H₄—CH₂ 647 — H 2-SO₂CH₃—C₆H₄—CH₂ 648 —H 3-SO₂CH₃—C₆H₄—CH₂ 649 — H 4-SO₂CH₃—C₆H₄—CH₂ 650 — H 2-OCF₃—C₆H₄—CH₂651 — H 3-OCF₃—C₆H₄—CH₂ 652 — H 4-OCF₃—C₆H₄—CH₂ 653 — H 2-OCHF₂—C₆H₄—CH₂654 — H 3-OCHF₂—C₆H₄—CH₂ 655 — H 4-OCHF₂—C₆H₄—CH₂ 656 — H 3-CF₃,4-OCF₃—C₆H₃—CH₂ 657 — H 1-naphthyl-CH₂ 658 — H 2-naphthyl-CH₂ 659 — H2-phenoxyeth-1-yl 660 — H 2-(2′-chlorophenoxy)eth-1-yl 661 — H2-(3′-chlorophenoxy)eth-1-yl 662 — H 2-(4′-chlorophenoxy)eth-1-yl 663 —H 2-(3′,5′-dichlorophenoxy)eth-1-yl 664 — H 2-(4′-cyanophenoxy)eth-1-yl665 — H 2-(3′-methylphenoxy)eth-1-yl 666 — H 2-(2′-nitrophenoxy)eth-1-yl667 — H 3-phenoxyprop-1-yl 668 — H 3-(4′-chlorophenoxy)prop-1-yl 669 — H3-(3′-cyanophenoxy)prop-1-yl 670 — H 3-(2′-methylphenoxy)prop-1-yl 671 —H 4-phenoxybut-1-yl 672 — H 2-phenyleth-1-yl 673 — H2-(4′-chlorophenyl)eth-1-yl 674 — H 2-(3′-cyanophenyl)eth-1-yl 675 — H2-(2′-methylphenyl)eth-1-yl 676 — H 3-phenylprop-1-yl 677 — H4-phenylbut-1-yl 678 — H 2-pyridylmethyl 679 — H 3-pyridylmethyl 680 — H4-pyridylmethyl 681 — H 4-chloropyridin-2-ylmethyl 682 — H5-chloropyridin-2-ylmethyl 683 — H 6-chloropyridin-2-ylmethyl 684 — H5-chloropyridin-3-ylmethyl 685 — H 6-chloropyridin-3-ylmethyl 686 — H2-chloropyridin-4-ylmethyl 687 — H 2-pyrimidinylmethyl 688 — H4-chloropyrimidin-2-ylmethyl 689 — H 5-chloropyrimidin-2-ylmethyl 690 —H 2-chloropyrimidin-4-ylmethyl 691 — H 6-chloropyrimidin-4-ylmethyl 692— H 2-chloropyrimidin-5-ylmethyl 693 — H 4-pyridazinylmethyl 694 — H2-pyrazinylmethyl 695 — H 5-chloropyrazin-2-ylmethyl 696 — H6-chloropyrazin-2-ylmethyl 697 — H 3-pyridazinylmethyl 698 — H6-chloropyridazin-3-ylmethyl 699 — H 1,3,5-triazinylmethyl 700 — H2-furylmethyl 701 — H 3-furylmethyl 702 — H 4-bromofur-2-ylmethyl 703 —H 5-chlorofur-2-ylmethyl 704 — H 2-thienylmethyl 705 — H 3-thienylmethyl706 — H 5-methylthien-3-ylmethyl 707 — H 5-chlorothien-2-ylmethyl 708 —H 2-chlorothien-4-ylmethyl 709 — H 2-pyrrolylmethyl 710 — H3-pyrrolylmethyl 711 — H 2-oxazolylmethyl 712 — H4-methyloxazol-2-ylmethyl 713 — H 5-methyloxazol-2-ylmethyl 714 — H4-chlorooxazol-2-ylmethyl 715 — H 5-chlorooxazol-2-ylmethyl 716 — H4-oxazolylmethyl 717 — H 2-methyloxazol-4-ylmethyl 718 — H5-methyloxazol-4-ylmethyl 719 — H 2-chlorooxazol-4-ylmethyl 720 — H5-chlorooxazol-4-ylmethyl 721 — H 5-oxazolylmethyl 722 — H2-methyloxazol-5-ylmethyl 723 — H 4-methyloxazol-5-ylmethyl 724 — H2-chlorooxazol-5-ylmethyl 725 — H 4-chlorooxazol-5-ylmethyl 726 — H2-thiazolylmethyl 727 — H 4-methylthiazol-2-ylmethyl 728 — H5-methylthiazol-2-ylmethyl 729 — H 4-chlorothiazol-2-ylmethyl 730 — H5-chlorothiazol-2-ylmethyl 731 — H 4-thiazolylmethyl 732 — H2-methylthiazol-4-ylmethyl 733 — H 5-methylthiazol-4-ylmethyl 734 — H2-chlorothiazol-4-ylmethyl 735 — H 5-chlorothiazol-4-ylmethyl 736 — H5-thiazolylmethyl 737 — H 2-methylthiazol-5-ylmethyl 738 — H4-methylthiazol-5-ylmethyl 739 — H 2-chlorothiazol-5-ylmethyl 740 — H4-chlorothiazol-5-ylmethyl 741 — H 3-isoxazolylmethyl 742 — H4-methylisoxazol-3-ylmethyl 743 — H 5-methylisoxazol-3-ylmethyl 744 — H4-chloroisoxazol-3-ylmethyl 745 — H 5-chloroisoxazol-3-ylmethyl 746 — H4-isoxazolylmethyl 747 — H 3-methylisoxazol-4-ylmethyl 748 — H5-methylisoxazol-4-ylmethyl 749 — H 3-chloroisoxazol-4-ylmethyl 750 — H5-chloroisoxazol-4-ylmethyl 751 — H 5-isoxazolylmethyl 752 — H3-methylisoxazol-5-ylmethyl 753 — H 4-methylisoxazol-5-ylmethyl 754 — H3-chloroisoxazol-5-ylmethyl 755 — H 4-chloroisoxazol-5-ylmethyl 756 — H3-isothiazolylmethyl 757 — H 4-methylisothiazol-3-ylmethyl 758 — H5-methylisothiazol-3-ylmethyl 759 — H 4-chloroisothiazol-3-ylmethyl 760— H 5-chloroisothiazol-3-ylmethyl 761 — H 4-isothiazolylmethyl 762 — H3-methylisothiazol-4-ylmethyl 763 — H 5-methylisothiazol-4-ylmethyl 764— H 3-chloroisothiazol-4-ylmethyl 765 — H 5-chloroisothiazol-4-ylmethyl766 — H 5-isothiazolylmethyl 767 — H 3-methylisothiazol-5-ylmethyl 768 —H 4-methylisothiazol-5-ylmethyl 769 — H 3-chloroisothiazol-5-ylmethyl770 — H 4-chloroisothiazol-5-ylmethyl 771 — H 4-imidazolylmethyl 772 — H1-phenylpyrazol-3-ylmethyl 773 — H 1-methylimidazol-4-ylmethyl 774 — H1-phenyl-1,2,4-triazol-3-ylmethyl 775 — H 1,2,4-oxadiazol-3-ylmethyl 776— H 5-chloro-1,2,4-oxadiazol-3-ylmethyl 777 — H5-methyl-1,2,4-oxadiazol-3-ylmethyl 778 — H5-trifluoromethyl-1,2,4-oxadiazol-3-ylmethyl 779 — H1,3,4-oxadiazol-2-ylmethyl 780 — H 5-chloro-1,3,4-oxadiazol-2-ylmethyl781 — H 5-methyl-1,3,4-oxadiazol-2-ylmethyl 782 — H5-methoxy-1,3,4-oxadiazol-2-ylmethyl 783 — H 1,2,4-thiadiazol-3-ylmethyl784 — H 5-chloro-1,2,4-thiadiazol-3-ylmethyl 785 — H5-methyl-1,2,4-thiadiazol-3-ylmethyl 786 — H 1,3,4-thiadiazol-2-ylmethyl787 — H 5-chloro-1,3,4-thiadiazol-2-ylmethyl 788 — H5-methyl-1,3,4-thiadiazol-2-ylmethyl 789 — H5-cyano-1,3,4-thiadiazol-2-ylmethyl 790 — H 2-(2′-pyridinyloxy)eth-1-yl791 — H 2-(3′-pyridinyloxy)eth-1-yl 792 — H 2-(4′-pyridinyloxy)eth-1-yl793 — H C₆H₅ 794 — H 2-Cl—C₆H₄ 795 — H 3-Cl—C₆H₄ 796 — H 4-Cl—C₆H₄ 797 —H 2,3-Cl₂—C₆H₃ 798 — H 2,4-Cl₂—C₆H₃ 799 — H 2,5-Cl₂—C₆H₃ 800 — H3,4-Cl₂—C₆H₃ 801 — H 3,5-Cl₂—C₆H₃ 802 — H 4-CN—C₆H₄ 803 — H 2-NO₂—C₆H₄804 — H 3-NO₂—C₆H₄ 805 — H 4-NO₂—C₆H₄ 806 — H 2,4-(NO₂)₂—C₆H₃ 807 — H2-CH₃—C₆H₄ 808 — H 3-CH₃—C₆H₄ 809 — H 4-CH₃—C₆H₄ 810 — H 2,3-(CH₃)₂—C₆H₃811 — H 2,4-(CH₃)₂—C₆H₃ 812 — H 2,5-(CH₃)₂—C₆H₃ 813 — H 2,6-(CH₃)₂—C₆H₃814 — H 2-C₆H₅—C₆H₄ 815 — H 3-C₆H₅—C₆H₄ 816 — H 4-C₆H₅—C₆H₄ 817 — H3-OCH₃—C₆H₄ 818 — H 4-OCH₃—C₆H₄ 819 — H 3-acetyl-C₆H₄ 820 — H4-acetyl-C₆H₄ 821 — H 3-methoxycarbonyl-C₆H₄ 822 — H4-methoxycarbonyl-C₆H₄ 823 — H 3-CF₃—C₆H₄ 824 — H 4-CF₃—C₆H₄ 825 — H2-naphthyl 826 — H 6-chloropyridazin-3-yl 827 — H 5-chloropyrazin-2-yl828 — H quinolin-2-yl 829 — H 2,5-dimethylpyrazin-3-yl 830 — Hpyrazin-2-yl 831 — H 3-chloropyrid-2-yl 832 — H 6-chloropyrid-2-yl 833 —H 4-trifluoromethyl, 6-chloropyrid-2-yl 834 — H4-trifluoromethylpyrid-2-yl 835 — H 6-trifluoromethylpyrid-2-yl 836 — H6-methoxypyrid-2-yl 837 — H 5-chloropyrid-2-yl 838 — H pyrid-2-yl 839 —H benzothiazol-2-yl 840 — H 7-chloroquinolin-4-yl 841 — H3-nitropyrid-2-yl 842 — H pyrrol-3-yl 843 — H pyrrol-2-yl 844 — H2,6-dioctylpyrid-4-yl 845 — H 5-nitropyrid-2-yl 846 — H pyrid-4-yl 847 —H pyrid-3-yl 848 — H pyrimidin-2-yl 849 — H pyrimidin-4-yl 850 — Hquinazolin-4-yl 851 — H 6-chloropyrimidin-4-yl 852 — H6-methoxypyrimidin-4-yl 853 — H 2,5,6-trichloropyrimidin-4-yl 854 — H2,6-dimethylpyrimidin-4-yl 855 — H 2-methyl, 6-chloropyrimidin-4-yl 856— H 2-methyl, 6-ethoxypyrimidin-4-yl 857 — H4,5,6-trichloropyrimidin-2-yl 858 — H 4,6-dimethoxypyrimidin-2-yl 859 —H 4,6-dimethylpyrimidin-2-yl 860 — H 4,6-dichloropyrimidin-2-yl 861 — H4-methyl, 6-methoxypyrimidin-2-yl 862 — H 4-chloro,6-methoxypyrimidin-2-yl 863 — H 6-chloroquinoxalin-2-yl 864 — H3,6-dichloro-1,2,4-triazin-5-yl 865 — H 4-methoxy-1,3,5-triazin-2-yl 866— H 4-ethoxy-1,3,5-triazin-2-yl 867 — H 4,6-dichloro-1,3,5-triazin-2-yl868 — H 4-ethoxy, 6-chloro-1,3,5-triazin-2-yl 869 — H isoxazol-3-yl 870— H thien-2-yl 871 — H fur-2-yl 872 — H thiatriazol-5-yl 873 — H(E)-1-chloropropen-3-yl 874 — H (E)-4-(4′-chlorophenyl)but-2-en-1-yl 875— H propyn-3-yl 876 — H methylcarbonyl 877 — H 2-t-C₄H₉—C₆H₄—CH₂ 878 — H3-t-C₄H₉—C₆H₄—CH₂ 879 — H 4-t-C₄H₉—C₆H₄—CH₂ 880 — H2-(4′-chlorothiazol-2′-yloxy)eth-1-yl 881 — H2-(1′-methylpyrazol-4′-yloxy)eth-1-yl 882 — H 4-Br—C₆H₄ 883 — H3,5-(CH₃)₂—C₆H₃ 884 — H 4-C₂H₅—C₆H₄ 885 — H 3-dimethylaminocarbonyl-C₆H₄886 — H 4-dimethylaminocarbonyl-C₆H₄ 887 — H 2-hydroxyprop-1-yl 888 — H6-hydroxy-2-methylpyrimidin-4-ylmethyl 889 — H[6-OH,2-CH(CH₃)₂-pyrimidin-4-yl]-CH₂ 890 — H[6-OH,2-CH(CH₂)₂-pyrimidin-4-yl]-CH₂ 891 — H 5-(2′-furan)-pent-1-yl 892— H 5-(2′-N-methylpyrrole)-pent-1-yl 893 — H[2-(4-Cl—C₆H₄)-oxazol-4-yl]-CH₂ 894 — H 3-CF₃-pyridin-2-yl 895 — H5-CF₃-pyridin-2-yl 896 — H 6-(2′-thienyl)hex-1-yl 897 O CH₃ H 898 O CH₃CH₃ 899 O CH₃ C₂H₅ 900 O CH₃ n-C₃H₇ 901 O CH₃ i-C₃H₇ 902 O CH₃cyclopropyl 903 O CH₃ n-C₄H₉ 904 O CH₃ s-C₄H₉ 905 O CH₃ i-C₄H₉ 906 O CH₃t-C₄H₉ 907 O CH₃ n-C₅H₁₁ 908 O CH₃ i-C₅H₁₁ 909 O CH₃ neo-C₅H₁₁ 910 O CH₃cyclopentyl 911 O CH₃ n-C₆H₁₃ 912 O CH₃ cyclohexyl 913 O CH₃ CH₂CH₂Cl914 O CH₃ (CH₂)₄Cl 915 O CH₃ CH₂CN 916 O CH₃ CH₂CH₂CN 917 O CH₃ (CH₂)₃CN918 O CH₃ (CH₂)₄CN 919 O CH₃ (CH₂)₆CN 920 O CH₃ cyclohexylmethyl 921 OCH₃ 2-cyclohexyleth-1-yl 922 O CH₃ cyclopropylmethyl 923 O CH₃2-cyclopropyleth-1-yl 924 O CH₃ 2-methoxyeth-1-yl 925 O CH₃2-ethoxyeth-1-yl 926 O CH₃ 2-isopropoxyeth-1-yl 927 O CH₃3-methoxyprop-1-yl 928 O CH₃ 3-ethoxyprop-1-yl 929 O CH₃3-isopropoxyprop-1-yl 930 O CH₃ 4-methoxybut-1-yl 931 O CH₃4-isopropoxybut-1-yl 932 O CH₃ propen-3-yl 933 O CH₃ but-2-en-1-yl 934 OCH₃ 3-methylbut-2-en-1-yl 935 O CH₃ 2-vinyloxyeth-1-yl 936 O CH₃allyloxyeth-1-yl 937 O CH₃ 2-trifluoromethoxyeth-1-yl 938 O CH₃3-trifluoromethoxyprop-1-yl 939 O CH₃ 4-difluoromethoxybut-1-yl 940 OCH₃ hydroxycarbonylmethyl 941 O CH₃ methoxycarbonylmethyl 942 O CH₃aminocarbonylmethyl 943 O CH₃ N-methylaminocarbonylmethyl 944 O CH₃N,N-dimethylaminocarbonyl-methyl 945 O CH₃ 2-hydroxycarbonyleth-1-yl 946O CH₃ 2-methoxycarbonyleth-1-yl 947 O CH₃ 2-aminocarbonyleth-1-yl 948 OCH₃ 2-N-methylaminocarbonyleth-1-yl 949 O CH₃2-dimethylaminocarbonyleth-1-yl 950 O CH₃ 2-aminoeth-1-yl 951 O CH₃2-aminoprop-1-yl 952 O CH₃ 4-aminobut-1-yl 953 O CH₃3-dimethylaminoprop-1-yl 954 O CH₃ 4-aminothiocarbonylbut-1-yl 955 O CH₃6-aminocarbonylhex-1-yl 956 O CH₃ 3-aminothiocarbonylprop-1-yl 957 O CH₃2-aminothiocarbonyleth-1-yl 958 O CH₃ aminothiocarbonylmethyl 959 O CH₃4-(N,N-dimethylamino)but-1-yl 960 O CH₃ 2-(methylthio)eth-1-yl 961 O CH₃2-(methylsulfonyl)eth-1-yl 962 O CH₃ 4-(methylthio)prop-1-yl 963 O CH₃4-(methylsulfonyl)prop-1-yl 964 O CH₃ benzyl 965 O CH₃ 2-F—C₆H₄—CH₂ 966O CH₃ 3-F—C₆H₄—CH₂ 967 O CH₃ 4-F—C₆H₄—CH₂ 968 O CH₃ 2,3-F₂—C₆H₃—CH₂ 969O CH₃ 2,4-F₂—C₆H₃—CH₂ 970 O CH₃ 2,5-F₂—C₆H₃—CH₂ 971 O CH₃2,6-F₂—C₆H₃—CH₂ 972 O CH₃ 3,4-F₂—C₆H₃—CH₂ 973 O CH₃ 3,5-F₂—C₆H₃—CH₂ 974O CH₃ 2-Cl—C₆H₄—CH₂ 975 O CH₃ 3-Cl—C₆H₄—CH₂ 976 O CH₃ 4-Cl—C₆H₄—CH₂ 977O CH₃ 2,3-Cl₂—C₆H₃—CH₂ 978 O CH₃ 2,4-Cl₂—C₆H₃—CH₂ 979 O CH₃2,5-Cl₂—C₆H₃—CH₂ 980 O CH₃ 2,6-Cl₂—C₆H₃—CH₂ 981 O CH₃ 3,4-Cl₂—C₆H₃—CH₂982 O CH₃ 3,5-Cl₂—C₆H₃—CH₂ 983 O CH₃ 2,3,4-Cl₃—C₆H₂—CH₂ 984 O CH₃2,3,5-Cl₃—C₆H₂—CH₂ 985 O CH₃ 2,3,6-Cl₃—C₆H₂—CH₂ 986 O CH₃2,4,5-Cl₃—C₆H₂—CH₂ 987 O CH₃ 2,4,6-Cl₃—C₆H₂—CH₂ 988 O CH₃3,4,5-Cl₃—C₆H₂—CH₂ 989 O CH₃ 2-Br—C₆H₄—CH₂ 990 O CH₃ 3-Br—C₆H₄—CH₂ 991 OCH₃ 4-Br—C₆H₄—CH₂ 992 O CH₃ 2,3-Br₂—C₆H₃—CH₂ 993 O CH₃ 2,4-Br₂—C₆H₃—CH₂994 O CH₃ 2,5-Br₂—C₆H₃—CH₂ 995 O CH₃ 2,6-Br₂—C₆H₃—CH₂ 996 O CH₃3,4-Br₂—C₆H₃—CH₂ 997 O CH₃ 3,5-Br₂—C₆H₃—CH₂ 998 O CH₃ 2-F, 3-Cl—C₆H₃—CH₂999 O CH₃ 2-F, 4-Cl—C₆H₃—CH₂ 1000 O CH₃ 2-F, 5-Cl—C₆H₃—CH₂ 1001 O CH₃2-F, 3-Br—C₆H₃—CH₂ 1002 O CH₃ 2-F, 4-Br—C₆H₃—CH₂ 1003 O CH₃ 2-F,5-Br—C₆H₃—CH₂ 1004 O CH₃ 2-Cl, 3-Br—C₆H₃—CH₂ 1005 O CH₃ 2-Cl,4-Br—C₆H₃—CH₂ 1006 O CH₃ 2-Cl, 5-Br—C₆H₃—CH₂ 1007 O CH₃ 3-F,4-Cl—C₆H₃—CH₂ 1008 O CH₃ 3-F, 5-Cl—C₆H₃—CH₂ 1009 O CH₃ 3-F,6-Cl—C₆H₃—CH₂ 1010 O CH₃ 3-F, 4-Br—C₆H₃—CH₂ 1011 O CH₃ 3-F,5-Br—C₆H₃—CH₂ 1012 O CH₃ 3-F, 6-Br—C₆H₃—CH₂ 1013 O CH₃ 3-Cl,4-Br—C₆H₃—CH₂ 1014 O CH₃ 3-Cl, 5-Br—C₆H₃—CH₂ 1015 O CH₃ 3-Cl,6-Br—C₆H₃—CH₂ 1016 O CH₃ 4-F, 5-Cl—C₆H₃—CH₂ 1017 O CH₃ 4-F,6-Cl—C₆H₃—CH₂ 1018 O CH₃ 4-F, 5-Br—C₆H₃—CH₂ 1019 O CH₃ 4-F,6-Br—C₆H₃—CH₂ 1020 O CH₃ 4-Cl, 5-Br—C₆H₃—CH₂ 1021 O CH₃ 5-F,6-Cl—C₆H₃—CH₂ 1022 O CH₃ 5-F, 6-Br—C₆H₃—CH₂ 1023 O CH₃ 5-Cl,6-Br—C₆H₃—CH₂ 1024 O CH₃ 3-Br, 4-Cl, 5-Br—C₆H₂—CH₂ 1025 O CH₃2-CN—C₆H₄—CH₂ 1026 O CH₃ 3-CN—C₆H₄—CH₂ 1027 O CH₃ 4-CN—C₆H₄—CH₂ 1028 OCH₃ 2-NO₂—C₆H₄—CH₂ 1029 O CH₃ 3-NO₂—C₆H₄—CH₂ 1030 O CH₃ 4-NO₂—C₆H₄—CH₂1031 O CH₃ 2-CH₃—C₆H₄—CH₂ 1032 O CH₃ 3-CH₃—C₆H₄—CH₂ 1033 O CH₃4-CH₃—C₆H₄—CH₂ 1034 O CH₃ 2,3-(CH₃)₂—C₆H₃—CH₂ 1035 O CH₃2,4-(CH₃)₂—C₆H₃—CH₂ 1036 O CH₃ 2,5-(CH₃)₂—C₆H₃—CH₂ 1037 O CH₃2,6-(CH₃)₂—C₆H₃—CH₂ 1038 O CH₃ 3,4-(CH₃)₂—C₆H₃—CH₂ 1039 O CH₃3,5-(CH₃)₂—C₆H₃—CH₂ 1040 O CH₃ 2-C₂H₅—C₆H₄—CH₂ 1041 O CH₃3-C₂H₅—C₆H₄—CH₂ 1042 O CH₃ 4-C₂H₅—C₆H₄—CH₂ 1043 O CH₃ 2-i-C₃H₇—C₆H₄—CH₂1044 O CH₃ 3-i-C₃H₇—C₆H₄—CH₂ 1045 O CH₃ 4-i-C₃H₇—C₆H₄—CH₂ 1046 O CH₃2-cyclohexyl-C₆H₄—CH₂ 1047 O CH₃ 3-cyclohexyl-C₆H₄—CH₂ 1048 O CH₃4-cyclohexyl-C₆H₄—CH₂ 1049 O CH₃ 2-vinyl-C₆H₄—CH₂ 1050 O CH₃3-vinyl-C₆H₄—CH₂ 1051 O CH₃ 4-vinyl-C₆H₄—CH₂ 1052 O CH₃ 2-allyl-C₆H₄—CH₂1053 O CH₃ 3-allyl-C₆H₄—CH₂ 1054 O CH₃ 4-allyl-C₆H₄—CH₂ 1055 O CH₃2-C₆H₅—C₆H₄—CH₂ 1056 O CH₃ 3-C₆H₅—C₆H₄—CH₂ 1057 O CH₃ 4-C₆H₅—C₆H₄—CH₂1058 O CH₃ 3-CH₃, 5-t-C₄H₉—C₆H₃—CH₂ 1059 O CH₃ 2-OH—C₆H₄—CH₂ 1060 O CH₃3-OH—C₆H₄—CH₂ 1061 O CH₃ 4-OH—C₆H₄—CH₂ 1062 O CH₃ 2-OCH₃—C₆H₄—CH₂ 1063 OCH₃ 3-OCH₃—C₆H₄—CH₂ 1064 O CH₃ 4-OCH₃—C₆H₄—CH₂ 1065 O CH₃2-O-allyl-C₆H₄—CH₂ 1066 O CH₃ 3-O-allyl-C₆H₄—CH₂ 1067 O CH₃4-O-allyl-C₆H₄—CH₂ 1068 O CH₃ 2-CF₃—C₆H₄—CH₂ 1069 O CH₃ 3-CF₃—C₆H₄—CH₂1070 O CH₃ 4-CF₃—C₆H₄—CH₂ 1071 O CH₃ 2-acetyl-C₆H₄—CH₂ 1072 O CH₃3-acetyl-C₆H₄—CH₂ 1073 O CH₃ 4-acetyl-C₆H₄—CH₂ 1074 O CH₃2-methoxycarbonyl-C₆H₄—CH₂ 1075 O CH₃ 3-methoxycarbonyl-C₆H₄—CH₂ 1076 OCH₃ 4-methoxycarbonyl-C₆H₄—CH₂ 1077 O CH₃ 2-aminocarbonyl-C₆H₄—CH₂ 1078O CH₃ 3-aminocarbonyl-C₆H₄—CH₂ 1079 O CH₃ 4-aminocarbonyl-C₆H₄—CH₂ 1080O CH₃ 2-dimethylaminocarbonyl-C₆H₄—CH₂ 1081 O CH₃3-dimethylaminocarbonyl-C₆H₄—CH₂ 1082 O CH₃4-dimethylaminocarbonyl-C₆H₄—CH₂ 1083 O CH₃2-(N-methylaminocarbonyl)-C₆H₄—CH₂ 1084 O CH₃3-(N-methylaminocarbonyl)-C₆H₄—CH₂ 1085 O CH₃4-(N-methylaminocarbonyl)-C₆H₄—CH₂ 1086 O CH₃ 2-H₂N—C₆H₄—CH₂ 1087 O CH₃3-H₂N—C₆H₄—CH₂ 1088 O CH₃ 4-H₂N—C₆H₄—CH₂ 1089 O CH₃2-aminothiocarbonyl-C₆H₄—CH₂ 1090 O CH₃ 3-aminothiocarbonyl-C₆H₄—CH₂1091 O CH₃ 4-aminothiocarbonyl-C₆H₄—CH₂ 1092 O CH₃ 2-SCH₃—C₆H₄—CH₂ 1093O CH₃ 3-SCH₃—C₆H₄—CH₂ 1094 O CH₃ 4-SCH₃—C₆H₄—CH₂ 1095 O CH₃2-SO₂CH₃—C₆H₄—CH₂ 1096 O CH₃ 3-SO₂CH₃—C₆H₄—CH₂ 1097 O CH₃4-SO₂CH₃—C₆H₄—CH₂ 1098 O CH₃ 2-OCF₃—C₆H₄—CH₂ 1099 O CH₃ 3-OCF₃—C₆H₄—CH₂1100 O CH₃ 4-OCF₃—C₆H₄—CH₂ 1101 O CH₃ 2-OCHF₂—C₆H₄—CH₂ 1102 O CH₃3-OCHF₂—C₆H₄—CH₂ 1103 O CH₃ 4-OCHF₂—C₆H₄—CH₂ 1104 O CH₃ 3-CF₃,4-OCF₃—C₆H₃—CH₂ 1105 O CH₃ 1-naphthyl-CH₂ 1106 O CH₃ 2-naphthyl-CH₂ 1107O CH₃ 2-phenoxyeth-1-yl 1108 O CH₃ 2-(2′-chlorophenoxy)eth-1-yl 1109 OCH₃ 2-(3′-chlorophenoxy)eth-1-yl 1110 O CH₃ 2-(4′-chlorophenoxy)eth-1-yl1111 O CH₃ 2-(3′,5′-dichlorophenoxy)eth-1-yl 1112 O CH₃2-(4′-cyanophenoxy)eth-1-yl 1113 O CH₃ 2-(3′-methylphenoxy)eth-1-yl 1114O CH₃ 2-(2′-nitrophenoxy)eth-1-yl 1115 O CH₃ 3-phenoxyprop-1-yl 1116 OCH₃ 3-(4′-chlorophenoxy)prop-1-yl 1117 O CH₃3-(3′-cyanophenoxy)prop-1-yl 1118 O CH₃ 3-(2′-methylphenoxy)prop-1-yl1119 O CH₃ 4-phenoxybut-1-yl 1120 O CH₃ 2-phenyleth-1-yl 1121 O CH₃2-(4′-chlorophenyl)eth-1-yl 1122 O CH₃ 2-(3′-cyanophenyl)eth-1-yl 1123 OCH₃ 2-(2′-methylphenyl)eth-1-yl 1124 O CH₃ 3-phenylprop-1-yl 1125 O CH₃4-phenylbut-1-yl 1126 O CH₃ 2-pyridylmethyl 1127 O CH₃ 3-pyridylmethyl1128 O CH₃ 4-pyridylmethyl 1129 O CH₃ 4-chloropyridin-2-ylmethyl 1130 OCH₃ 5-chloropyridin-2-ylmethyl 1131 O CH₃ 6-chloropyridin-2-ylmethyl1132 O CH₃ 5-chloropyridin-3-ylmethyl 1133 O CH₃6-chloropyridin-3-ylmethyl 1134 O CH₃ 2-chloropyridin-4-ylmethyl 1135 OCH₃ 2-pyrimidinylmethyl 1136 O CH₃ 4-chloropyrimidin-2-ylmethyl 1137 OCH₃ 5-chloropyrimidin-2-ylmethyl 1138 O CH₃ 2-chloropyrimidin-4-ylmethyl1139 O CH₃ 6-chloropyrimidin-4-ylmethyl 1140 O CH₃2-chloropyrimidin-5-ylmethyl 1141 O CH₃ 4-pyridazinylmethyl 1142 O CH₃2-pyrazinylmethyl 1143 O CH₃ 5-chloropyrazin-2-ylmethyl 1144 O CH₃6-chloropyrazin-2-ylmethyl 1145 O CH₃ 3-pyridazinylmethyl 1146 O CH₃6-chloropyridazin-3-ylmethyl 1147 O CH₃ 1,3,5-triazinylmethyl 1148 O CH₃2-furylmethyl 1149 O CH₃ 3-furylmethyl 1150 O CH₃ 4-bromofur-2-ylmethyl1151 O CH₃ 5-chlorofur-2-ylmethyl 1152 O CH₃ 2-thienylmethyl 1153 O CH₃3-thienylmethyl 1154 O CH₃ 5-methylthien-3-ylmethyl 1155 O CH₃5-chlorothien-2-ylmethyl 1156 O CH₃ 2-chlorothien-4-ylmethyl 1157 O CH₃2-pyrrolylmethyl 1158 O CH₃ 3-pyrrolylmethyl 1159 O CH₃ 2-oxazolylmethyl1160 O CH₃ 4-methyloxazol-2-ylmethyl 1161 O CH₃5-methyloxazol-2-ylmethyl 1162 O CH₃ 4-chlorooxazol-2-ylmethyl 1163 OCH₃ 5-chlorooxazol-2-ylmethyl 1164 O CH₃ 4-oxazolylmethyl 1165 O CH₃2-methyloxazol-4-ylmethyl 1166 O CH₃ 5-methyloxazol-4-ylmethyl 1167 OCH₃ 2-chlorooxazol-4-ylmethyl 1168 O CH₃ 5-chlorooxazol-4-ylmethyl 1169O CH₃ 5-oxazolylmethyl 1170 O CH₃ 2-methyloxazol-5-ylmethyl 1171 O CH₃4-methyloxazol-5-ylmethyl 1172 O CH₃ 2-chlorooxazol-5-ylmethyl 1173 OCH₃ 4-chlorooxazol-5-ylmethyl 1174 O CH₃ 2-thiazolylmethyl 1175 O CH₃4-methylthiazol-2-ylmethyl 1176 O CH₃ 5-methylthiazol-2-ylmethyl 1177 OCH₃ 4-chlorothiazol-2-ylmethyl 1178 O CH₃ 5-chlorothiazol-2-ylmethyl1179 O CH₃ 4-thiazolylmethyl 1180 O CH₃ 2-methylthiazol-4-ylmethyl 1181O CH₃ 5-methylthiazol-4-ylmethyl 1182 O CH₃ 2-chlorothiazol-4-ylmethyl1183 O CH₃ 5-chlorothiazol-4-ylmethyl 1184 O CH₃ 5-thiazolylmethyl 1185O CH₃ 2-methylthiazol-5-ylmethyl 1186 O CH₃ 4-methylthiazol-5-ylmethyl1187 O CH₃ 2-chlorothiazol-5-ylmethyl 1188 O CH₃4-chlorothiazol-5-ylmethyl 1189 O CH₃ 3-isoxazolylmethyl 1190 O CH₃4-methylisoxazol-3-ylmethyl 1191 O CH₃ 5-methylisoxazol-3-ylmethyl 1192O CH₃ 4-chloroisoxazol-3-ylmethyl 1193 O CH₃ 5-chloroisoxazol-3-ylmethyl1194 O CH₃ 4-isoxazolylmethyl 1195 O CH₃ 3-methylisoxazol-4-ylmethyl1196 O CH₃ 5-methylisoxazol-4-ylmethyl 1197 O CH₃3-chloroisoxazol-4-ylmethyl 1198 O CH₃ 5-chloroisoxazol-4-ylmethyl 1199O CH₃ 5-isoxazolylmethyl 1200 O CH₃ 3-methylisoxazol-5-ylmethyl 1201 OCH₃ 4-methylisoxazol-5-ylmethyl 1202 O CH₃ 3-chloroisoxazol-5-ylmethyl1203 O CH₃ 4-chloroisoxazol-5-ylmethyl 1204 O CH₃ 3-isothiazolylmethyl1205 O CH₃ 4-methylisothiazol-3-ylmethyl 1206 O CH₃5-methylisothiazol-3-ylmethyl 1207 O CH₃ 4-chloroisothiazol-3-ylmethyl1208 O CH₃ 5-chloroisothiazol-3-ylmethyl 1209 O CH₃ 4-isothiazolylmethyl1210 O CH₃ 3-methylisothiazol-4-ylmethyl 1211 O CH₃5-methylisothiazol-4-ylmethyl 1212 O CH₃ 3-chloroisothiazol-4-ylmethyl1213 O CH₃ 5-chloroisothiazol-4-ylmethyl 1214 O CH₃ 5-isothiazolylmethyl1215 O CH₃ 3-methylisothiazol-5-ylmethyl 1216 O CH₃4-methylisothiazol-5-ylmethyl 1217 O CH₃ 3-chloroisothiazol-5-ylmethyl1218 O CH₃ 4-chloroisothiazol-5-ylmethyl 1219 O CH₃ 4-imidazolylmethyl1220 O CH₃ 1-phenylpyrazol-3-ylmethyl 1221 O CH₃1-methylimidazol-4-ylmethyl 1222 O CH₃ 1-phenyl-1,2,4-triazol-3-ylmethyl1223 O CH₃ 1,2,4-oxadiazol-3-ylmethyl 1224 O CH₃5-chloro-1,2,4-oxadiazol-3-ylmethyl 1225 O CH₃5-methyl-1,2,4-oxadiazol-3-ylmethyl 1226 O CH₃5-trifluoromethyl-1,2,4-oxadiazol-3-ylmethyl 1227 O CH₃1,3,4-oxadiazol-2-ylmethyl 1228 O CH₃5-chloro-1,3,4-oxadiazol-2-ylmethyl 1229 O CH₃5-methyl-1,3,4-oxadiazol-2-ylmethyl 1230 O CH₃5-methoxy-1,3,4-oxadiazol-2-ylmethyl 1231 O CH₃1,2,4-thiadiazol-3-ylmethyl 1232 O CH₃5-chloro-1,2,4-thiadiazol-3-ylmethyl 1233 O CH₃5-methyl-1,2,4-thiadiazol-3-ylmethyl 1234 O CH₃1,3,4-thiadiazol-2-ylmethyl 1235 O CH₃5-chloro-1,3,4-thiadiazol-2-ylmethyl 1236 O CH₃5-methyl-1,3,4-thiadiazol-2-ylmethyl 1237 O CH₃5-cyano-1,3,4-thiadiazol-2-ylmethyl 1238 O CH₃2-(2′-pyridinyloxy)eth-1-yl 1239 O CH₃ 2-(3′-pyridinyloxy)eth-1-yl 1240O CH₃ 2-(4′-pyridinyloxy)eth-1-yl 1241 O CH₃ C₆H₅ 1242 O CH₃ 2-Cl—C₆H₄1243 O CH₃ 3-Cl—C₆H₄ 1244 O CH₃ 4-Cl—C₆H₄ 1245 O CH₃ 2,3-Cl₂—C₆H₃ 1246 OCH₃ 2,4-Cl₂—C₆H₃ 1247 O CH₃ 2,5-Cl₂—C₆H₃ 1248 O CH₃ 3,4-Cl₂—C₆H₃ 1249 OCH₃ 3,5-Cl₂—C₆H₃ 1250 O CH₃ 4-CN—C₆H₄ 1251 O CH₃ 2-NO₂—C₆H₄ 1252 O CH₃3-NO₂—C₆H₄ 1253 O CH₃ 4-NO₂—C₆H₄ 1254 O CH₃ 2,4-(NO₂)₂—C₆H₃ 1255 O CH₃2-CH₃—C₆H₄ 1256 O CH₃ 3-CH₃—C₆H₄ 1257 O CH₃ 4-CH₃—C₆H₄ 1258 O CH₃2,3-(CH₃)₂—C₆H₃ 1259 O CH₃ 2,4-(CH₃)₂—C₆H₃ 1260 O CH₃ 2,5-(CH₃)₂—C₆H₃1261 O CH₃ 2,6-(CH₃)₂—C₆H₃ 1262 O CH₃ 2-C₆H₅—C₆H₄ 1263 O CH₃ 3-C₆H₅—C₆H₄1264 O CH₃ 4-C₆H₅—C₆H₄ 1265 O CH₃ 3-OCH₃—C₆H₄ 1266 O CH₃ 4-OCH₃—C₆H₄1267 O CH₃ 3-acetyl-C₆H₄ 1268 O CH₃ 4-acetyl-C₆H₄ 1269 O CH₃3-methoxycarbonyl-C₆H₄ 1270 O CH₃ 4-methoxycarbonyl-C₆H₄ 1271 O CH₃3-CF₃—C₆H₄ 1272 O CH₃ 4-CF₃—C₆H₄ 1273 O CH₃ 2-naphthyl 1274 O CH₃6-chloropyridazin-3-yl 1275 O CH₃ 5-chloropyrazin-2-yl 1276 O CH₃quinolin-2-yl 1277 O CH₃ 2,5-dimethylpyrazin-3-yl 1278 O CH₃pyrazin-2-yl 1279 O CH₃ 3-chloropyrid-2-yl 1280 O CH₃ 6-chloropyrid-2-yl1281 O CH₃ 4-trifluoromethyl, 6-chloropyrid-2-yl 1282 O CH₃4-trifluoromethylpyrid-2-yl 1283 O CH₃ 6-trifluoromethylpyrid-2-yl 1284O CH₃ 6-methoxypyrid-2-yl 1285 O CH₃ 5-chloropyrid-2-yl 1286 O CH₃pyrid-2-yl 1287 O CH₃ benzothiazol-2-yl 1288 O CH₃ 7-chloroquinolin-4-yl1289 O CH₃ 3-nitropyrid-2-yl 1290 O CH₃ pyrrol-3-yl 1291 O CH₃pyrrol-2-yl 1292 O CH₃ 2,6-dioctylpyrid-4-yl 1293 O CH₃5-nitropyrid-2-yl 1294 O CH₃ pyrid-4-yl 1295 O CH₃ pyrid-3-yl 1296 O CH₃pyrimidin-2-yl 1297 O CH₃ pyrimidin-4-yl 1298 O CH₃ quinazolin-4-yl 1299O CH₃ 6-chloropyrimidin-4-yl 1300 O CH₃ 6-methoxypyrimidin-4-yl 1301 OCH₃ 2,5,6-trichloropyrimidin-4-yl 1302 O CH₃ 2,6-dimethylpyrimidin-4-yl1303 O CH₃ 2-methyl, 6-chloropyrimidin-4-yl 1304 O CH₃ 2-methyl,6-ethoxypyrimidin-4-yl 1305 O CH₃ 4,5,6-trichloropyrimidin-2-yl 1306 OCH₃ 4,6-dimethoxypyrimidin-2-yl 1307 O CH₃ 4,6-dimethylpyrimidin-2-yl1308 O CH₃ 4,6-dichloropyrimidin-2-yl 1309 O CH₃ 4-methyl,6-methoxypyrimidin-2-yl 1310 O CH₃ 4-chloro, 6-methoxypyrimidin-2-yl1311 O CH₃ 6-chloroquinoxalin-2-yl 1312 O CH₃3,6-dichloro-1,2,4-triazin-5-yl 1313 O CH₃ 4-methoxy-1,3,5-triazin-2-yl1314 O CH₃ 4-ethoxy-1,3,5-triazin-2-yl 1315 O CH₃4,6-dichloro-1,3,5-triazin-2-yl 1316 O CH₃ 4-ethoxy,6-chloro-1,3,5-triazin-2-yl 1317 O CH₃ isoxazol-3-yl 1318 O CH₃thien-2-yl 1319 O CH₃ fur-2-yl 1320 O CH₃ thiatriazol-5-yl 1321 O CH₃(E)-1-chloropropen-3-yl 1322 O CH₃ (E)-4-(4′-chlorophenyl)but-2-en-1-yl1323 O CH₃ propyn-3-yl 1324 O CH₃ methylcarbonyl 1325 O CH₃2-t-C₄H₉—C₆H₄—CH₂ 1326 O CH₃ 3-t-C₄H₉—C₆H₄—CH₂ 1327 O CH₃4-t-C₄H₉—C₆H₄—CH₂ 1328 O CH₃ 2-(4′-chlorothiazol-2′-yloxy)eth-1-yl 1329O CH₃ 2-(1′-methylpyrazol-4′-yloxy)eth-1-yl 1330 O CH₃ 4-Br—C₆H₄ 1331 OCH₃ 3,5-(CH₃)₂—C₆H₃ 1332 O CH₃ 4-C₂H₅—C₆H₄ 1333 O CH₃3-dimethylaminocarbonyl-C₆H₄ 1334 O CH₃ 4-dimethylaminocarbonyl-C₆H₄1335 O CH₃ 2-hydroxyprop-1-yl 1336 O CH₃6-hydroxy-2-methylpyrimidin-4-ylmethyl 1337 O CH₃[6-OH,2-CH(CH₃)₂-pyrimidin-4-yl]-CH₂ 1338 O CH₃[6-OH,2-CH(CH₂)₂-pyrimidin-4-yl]-CH₂ 1339 O CH₃ 5-(2′-furan)pent-1-yl1340 O CH₃ 5-(2′-N-methylpyrrole)pent-1-yl 1341 O CH₃[2-(4-Cl—C₆H₄)-oxazol-4-yl]-CH₂ 1342 O CH₃ 3-CF₃-pyridin-2-yl 1343 O CH₃5-CF₃-pyridin-2-yl 1344 O CH₃ 6-(2′-thienyl)hex-1-yl 1345 O C₂H₅ H 1346O C₂H₅ CH₃ 1347 O C₂H₅ C₆H₅—CH₂ 1348 O i-C₃H₇ CH₃ 1349 NH H H 1350 NH HCH₃ 1351 NH H 4-Cl—C₆H₄—CH₂ 1352 NH CH₃ CH₃ 1353 NH CH₃ C₆H₅—CH₂ 1354NCH₃ CH₃ CH₃ 1355 NCH₃ CH₃ 4-CH₃—C₆H₄—CH₂ 1356 S CH₃ H 1357 S CH₃ CH₃1358 S CH₃ C₂H₅ 1359 S CH₃ C₆H₅—CH₂ 1360 — C₂H₅ H 1361 — C₂H₅ CH₃ 1362 —C₂H₅ C₆H₅—CH₂ 1363 — C₂H₅ 3-CN—C₆H₄—CH₂ 1364 — C₂H₅ prop-2-en-1-yl 1365— n-C₃H₇ H 1366 — n-C₃H₇ CH₃ 1367 — C₆H₅ H 1368 — C₆H₅ CH₃ 1369 — C₆H₅3-OCH₃—C₆H₄—CH₂ No. R^(c) Ap R^(a) e) R⁴ = 3-NR^(c)—(C═O)—Ap—R^(a) 1 H —H 2 H — CH₃ 3 H — C₂H₅ 4 H — n-C₃H₇ 5 H — i-C₃H₇ 6 H — cyclopropyl 7 H —n-C₄H₉ 8 H — s-C₄H₉ 9 H — i-C₄H₉ 10 H — t-C₄H₉ 11 H — n-C₅H₁₁ 12 H —i-C₅H₁₁ 13 H — neo-C₅H₁₁ 14 H — cyclopentyl 15 H — n-C₆H₁₃ 16 H —cyclohexyl 17 H — CF₃ 18 H — ethenyl 19 H — propen-3-yl 20 H — benzyl 21H — phenyl 22 H O H 23 H O CH₃ 24 H O C₂H₅ 25 H O n-C₃H₇ 26 H O i-C₃H₇27 H O cyclopropyl 28 H O n-C₄H₉ 29 H O s-C₄H₉ 30 H O i-C₄H₉ 31 H Ot-C₄H₉ 32 H O n-C₅H₁₁ 33 H O i-C₅H₁₁ 34 H O neo-C₅H₁₁ 35 H O cyclopentyl36 H O n-C₆H₁₃ 37 H O cyclohexyl 38 H O CF₃ 39 H O propyn-3-yl 40 H Opropen-3-yl 41 H O benzyl 42 H O phenyl 43 H NH H 44 H NH CH₃ 45 H NHC₂H₅ 46 H NH n-C₃H₇ 47 H NH i-C₃H₇ 48 H NH cyclopropyl 49 H NH n-C₄H₉ 50H NH s-C₄H₉ 51 H NH i-C₄H₉ 52 H NH t-C₄H₉ 53 H NH n-C₅H₁₁ 54 H NHi-C₅H₁₁ 55 H NH neo-C₅H₁₁ 56 H NH cyclopentyl 57 H NH n-C₆H₁₃ 58 H NHcyclohexyl 59 H NH cyclopropyl-CH₂ 60 H NH propyn-3-yl 61 H NHpropen-3-yl 62 H NH benzyl 63 H NH phenyl 64 H NCH₃ CH₃ 65 H NCH₃ C₂H₅66 H NCH₃ n-C₃H₇ 67 H NCH₃ i-C₃H₇ 68 H NCH₃ cyclopropyl 69 H NCH₃ n-C₄H₉70 H NCH₃ s-C₄H₉ 71 H NCH₃ i-C₄H₉ 72 H NCH₃ t-C₄H₉ 73 H NCH₃ n-C₅H₁₁ 74H NCH₃ i-C₅H₁₁ 75 H NCH₃ neo-C₅H₁₁ 76 H NCH₃ cyclopentyl 77 H NCH₃n-C₆H₁₃ 78 H NCH₃ cyclohexyl 79 H NCH₃ cyclopropyl-CH₂ 80 H NCH₃propyn-3-yl 81 H NCH₃ propen-3-yl 82 H NCH₃ benzyl 83 H NCH₃ phenyl 84CH₃ — H 85 CH₃ — CH₃ 86 CH₃ — C₂H₅ 87 CH₃ — n-C₃H₇ 88 CH₃ — i-C₃H₇ 89CH₃ — cyclopropyl 90 CH₃ — n-C₄H₉ 91 CH₃ — s-C₄H₉ 92 CH₃ — i-C₄H₉ 93 CH₃— t-C₄H₉ 94 CH₃ — n-C₅H₁₁ 95 CH₃ — i-C₅H₁₁ 96 CH₃ — neo-C₅H₁₁ 97 CH₃ —cyclopentyl 98 CH₃ — n-C₆H₁₃ 99 CH₃ — cyclohexyl 100 CH₃ — CF₃ 101 CH₃ —ethenyl 102 CH₃ — propen-3-yl 103 CH₃ — benzyl 104 CH₃ — phenyl 105 CH₃O H 106 CH₃ O CH₃ 107 CH₃ O C₂H₅ 108 CH₃ O n-C₃H₇ 109 CH₃ O i-C₃H₇ 110CH₃ O cyclopropyl 111 CH₃ O n-C₄H₉ 112 CH₃ O s-C₄H₉ 113 CH₃ O i-C₄H₉ 114CH₃ O t-C₄H₉ 115 CH₃ O n-C₅H₁₁ 116 CH₃ O i-C₅H₁₁ 117 CH₃ O neo-C₅H₁₁ 118CH₃ O cyclopentyl 119 CH₃ O n-C₆H₁₃ 120 CH₃ O cyclohexyl 121 CH₃ O CF₃122 CH₃ O propyn-3-yl 123 CH₃ O propen-3-yl 124 CH₃ O benzyl 125 CH₃ Ophenyl 126 CH₃ NH H 127 CH₃ NH CH₃ 128 CH₃ NH C₂H₅ 129 CH₃ NH n-C₃H₇ 130CH₃ NH i-C₃H₇ 131 CH₃ NH cyclopropyl 132 CH₃ NH n-C₄H₉ 133 CH₃ NH s-C₄H₉134 CH₃ NH i-C₄H₉ 135 CH₃ NH t-C₄H₉ 136 CH₃ NH n-C₅H₁₁ 137 CH₃ NHi-C₅H₁₁ 138 CH₃ NH neo-C₅H₁₁ 139 CH₃ NH cyclopentyl 140 CH₃ NH n-C₆H₁₃141 CH₃ NH cyclohexyl 142 CH₃ NH cyclopropyl-CH₂ 143 CH₃ NH propyn-3-yl144 CH₃ NH propen-3-yl 145 CH₃ NH benzyl 146 CH₃ NH phenyl 147 CH₃ NCH₃CH₃ 148 CH₃ NCH₃ C₂H₅ 149 CH₃ NCH₃ n-C₃H₇ 150 CH₃ NCH₃ i-C₃H₇ 151 CH₃NCH₃ cyclopropyl 152 CH₃ NCH₃ n-C₄H₉ 153 CH₃ NCH₃ s-C₄H₉ 154 CH₃ NCH₃i-C₄H₉ 155 CH₃ NCH₃ t-C₄H₉ 156 CH₃ NCH₃ n-C₅H₁₁ 157 CH₃ NCH₃ i-C₅H₁₁ 158CH₃ NCH₃ neo-C₅H₁₁ 159 CH₃ NCH₃ cyclopentyl 160 CH₃ NCH₃ n-C₆H₁₃ 161 CH₃NCH₃ cyclohexyl 162 CH₃ NCH₃ cyclopropyl-CH₂ 163 CH₃ NCH₃ propyn-3-yl164 CH₃ NCH₃ propen-3-yl 165 CH₃ NCH₃ benzyl 166 CH₃ NCH₃ phenyl 167C₂H₅ — H 168 C₂H₅ — CH₃ 169 C₂H₅ — C₂H₅ 170 C₂H₅ — n-C₃H₇ 171 C₂H₅ —i-C₃H₇ 172 C₂H₅ — cyclopropyl 173 C₂H₅ — n-C₄H₉ 174 C₂H₅ — s-C₄H₉ 175C₂H₅ — i-C₄H₉ 176 C₂H₅ — t-C₄H₉ 177 C₂H₅ — n-C₅H₁₁ 178 C₂H₅ — i-C₅H₁₁179 C₂H₅ — neo-C₅H₁₁ 180 C₂H₅ — cyclopentyl 181 C₂H₅ — n-C₆H₁₃ 182 C₂H₅— cyclohexyl 183 C₂H₅ — CF₃ 184 C₂H₅ — ethenyl 185 C₂H₅ — propen-3-yl186 C₂H₅ — benzyl 187 C₂H₅ — phenyl 188 C₂H₅ O H 189 C₂H₅ O CH₃ 190 C₂H₅O C₂H₅ 191 C₂H₅ O n-C₃H₇ 192 C₂H₅ O i-C₃H₇ 193 C₂H₅ O cyclopropyl 194C₂H₅ O n-C₄H₉ 195 C₂H₅ O s-C₄H₉ 196 C₂H₅ O i-C₄H₉ 197 C₂H₅ O t-C₄H₉ 198C₂H₅ O n-C₅H₁₁ 199 C₂H₅ O i-C₅H₁₁ 200 C₂H₅ O neo-C₅H₁₁ 201 C₂H₅ Ocyclopentyl 202 C₂H₅ O n-C₆H₁₃ 203 C₂H₅ O cyclohexyl 204 C₂H₅ O CF₃ 205C₂H₅ O propyn-3-yl 206 C₂H₅ O propen-3-yl 207 C₂H₅ O benzyl 208 C₂H₅ Ophenyl 209 C₂H₅ NH H 210 C₂H₅ NH CH₃ 211 C₂H₅ NH C₂H₅ 212 C₂H₅ NH n-C₃H₇213 C₂H₅ NH i-C₃H₇ 214 C₂H₅ NH cyclopropyl 215 C₂H₅ NH n-C₄H₉ 216 C₂H₅NH s-C₄H₉ 217 C₂H₅ NH i-C₄H₉ 218 C₂H₅ NH t-C₄H₉ 219 C₂H₅ NH n-C₅H₁₁ 220C₂H₅ NH i-C₅H₁₁ 221 C₂H₅ NH neo-C₅H₁₁ 222 C₂H₅ NH cyclopentyl 223 C₂H₅NH n-C₆H₁₃ 224 C₂H₅ NH cyclohexyl 225 C₂H₅ NH cyclopropyl-CH₂ 226 C₂H₅NH propyn-3-yl 227 C₂H₅ NH propen-3-yl 228 C₂H₅ NH benzyl 229 C₂H₅ NHphenyl 230 C₂H₅ NCH₃ CH₃ 231 C₂H₅ NCH₃ C₂H₅ 232 C₂H₅ NCH₃ n-C₃H₇ 233C₂H₅ NCH₃ i-C₃H₇ 234 C₂H₅ NCH₃ cyclopropyl 235 C₂H₅ NCH₃ n-C₄H₉ 236 C₂H₅NCH₃ s-C₄H₉ 237 C₂H₅ NCH₃ i-C₄H₉ 238 C₂H₅ NCH₃ t-C₄H₉ 239 C₂H₅ NCH₃n-C₅H₁₁ 240 C₂H₅ NCH₃ i-C₅H₁₁ 241 C₂H₅ NCH₃ neo-C₅H₁₁ 242 C₂H₅ NCH₃cyclopentyl 243 C₂H₅ NCH₃ n-C₆H₁₃ 244 C₂H₅ NCH₃ cyclohexyl 245 C₂H₅ NCH₃cyclopropyl-CH₂ 246 C₂H₅ NCH₃ propyn-3-yl 247 C₂H₅ NCH₃ propen-3-yl 248C₂H₅ NCH₃ benzyl 249 C₂H₅ NCH₃ phenyl 250 n-C₃H₇ — H 251 n-C₃H₇ — CH₃252 n-C₃H₇ — C₂H₅ 253 n-C₃H₇ — n-C₃H₇ 254 n-C₃H₇ — i-C₃H₇ 255 n-C₃H₇ —cyclopropyl 256 n-C₃H₇ — n-C₄H₉ 257 n-C₃H₇ — s-C₄H₉ 258 n-C₃H₇ — i-C₄H₉259 n-C₃H₇ — t-C₄H₉ 260 n-C₃H₇ — n-C₅H₁₁ 261 n-C₃H₇ — i-C₅H₁₁ 262 n-C₃H₇— neo-C₅H₁₁ 263 n-C₃H₇ — cyclopentyl 264 n-C₃H₇ — n-C₆H₁₃ 265 n-C₃H₇ —cyclohexyl 266 n-C₃H₇ — CF₃ 267 n-C₃H₇ — ethenyl 268 n-C₃H₇ —propen-3-yl 269 n-C₃H₇ — benzyl 270 n-C₃H₇ — phenyl 271 n-C₃H₇ O H 272n-C₃H₇ O CH₃ 273 n-C₃H₇ O C₂H₅ 274 n-C₃H₇ O n-C₃H₇ 275 n-C₃H₇ O i-C₃H₇276 n-C₃H₇ O cyclopropyl 277 n-C₃H₇ O n-C₄H₉ 278 n-C₃H₇ O s-C₄H₉ 279n-C₃H₇ O i-C₄H₉ 280 n-C₃H₇ O t-C₄H₉ 281 n-C₃H₇ O n-C₅H₁₁ 282 n-C₃H₇ Oi-C₅H₁₁ 283 n-C₃H₇ O neo-C₅H₁₁ 284 n-C₃H₇ O cyclopentyl 285 n-C₃H₇ On-C₆H₁₃ 286 n-C₃H₇ O cyclohexyl 287 n-C₃H₇ O CF₃ 288 n-C₃H₇ Opropyn-3-yl 289 n-C₃H₇ O propen-3-yl 290 n-C₃H₇ O benzyl 291 n-C₃H₇ Ophenyl 292 n-C₃H₇ NH H 293 n-C₃H₇ NH CH₃ 294 n-C₃H₇ NH C₂H₅ 295 n-C₃H₇NH n-C₃H₇ 296 n-C₃H₇ NH i-C₃H₇ 297 n-C₃H₇ NH cyclopropyl 298 n-C₃H₇ NHn-C₄H₉ 299 n-C₃H₇ NH s-C₄H₉ 300 n-C₃H₇ NH i-C₄H₉ 301 n-C₃H₇ NH t-C₄H₉302 n-C₃H₇ NH n-C₅H₁₁ 303 n-C₃H₇ NH i-C₅H₁₁ 304 n-C₃H₇ NH neo-C₅H₁₁ 305n-C₃H₇ NH cyclopentyl 306 n-C₃H₇ NH n-C₆H₁₃ 307 n-C₃H₇ NH cyclohexyl 308n-C₃H₇ NH cyclopropyl-CH₂ 309 n-C₃H₇ NH propyn-3-yl 310 n-C₃H₇ NHpropen-3-yl 311 n-C₃H₇ NH benzyl 312 n-C₃H₇ NH phenyl 313 n-C₃H₇ NCH₃CH₃ 314 n-C₃H₇ NCH₃ C₂H₅ 315 n-C₃H₇ NCH₃ n-C₃H₇ 316 n-C₃H₇ NCH₃ i-C₃H₇317 n-C₃H₇ NCH₃ cyclopropyl 318 n-C₃H₇ NCH₃ n-C₄H₉ 319 n-C₃H₇ NCH₃s-C₄H₉ 320 n-C₃H₇ NCH₃ i-C₄H₉ 321 n-C₃H₇ NCH₃ t-C₄H₉ 322 n-C₃H₇ NCH₃n-C₅H₁₁ 323 n-C₃H₇ NCH₃ i-C₅H₁₁ 324 n-C₃H₇ NCH₃ neo-C₅H₁₁ 325 n-C₃H₇NCH₃ cyclopentyl 326 n-C₃H₇ NCH₃ n-C₆H₁₃ 327 n-C₃H₇ NCH₃ cyclohexyl 328n-C₃H₇ NCH₃ cyclopropyl-CH₂ 329 n-C₃H₇ NCH₃ propyn-3-yl 330 n-C₃H₇ NCH₃propen-3-yl 331 n-C₃H₇ NCH₃ benzyl 332 n-C₃H₇ NCH₃ phenyl 333 i-C₃H₇ — H334 i-C₃H₇ — CH₃ 335 i-C₃H₇ — C₂H₅ 336 i-C₃H₇ — n-C₃H₇ 337 i-C₃H₇ —i-C₃H₇ 338 i-C₃H₇ — cyclopropyl 339 i-C₃H₇ — n-C₄H₉ 340 i-C₃H₇ — s-C₄H₉341 i-C₃H₇ — i-C₄H₉ 342 i-C₃H₇ — t-C₄H₉ 343 i-C₃H₇ — n-C₅H₁₁ 344 i-C₃H₇— i-C₅H₁₁ 345 i-C₃H₇ — neo-C₅H₁₁ 346 i-C₃H₇ — cyclopentyl 347 i-C₃H₇ —n-C₆H₁₃ 348 i-C₃H₇ — cyclohexyl 349 i-C₃H₇ — CF₃ 350 i-C₃H₇ — ethenyl351 i-C₃H₇ — propen-3-yl 352 i-C₃H₇ — benzyl 353 i-C₃H₇ — phenyl 354i-C₃H₇ O H 355 i-C₃H₇ O CH₃ 356 i-C₃H₇ O C₂H₅ 357 i-C₃H₇ O n-C₃H₇ 358i-C₃H₇ O i-C₃H₇ 359 i-C₃H₇ O cyclopropyl 360 i-C₃H₇ O n-C₄H₉ 361 i-C₃H₇O s-C₄H₉ 362 i-C₃H₇ O i-C₄H₉ 363 i-C₃H₇ O t-C₄H₉ 364 i-C₃H₇ O n-C₅H₁₁365 i-C₃H₇ O i-C₅H₁₁ 366 i-C₃H₇ O neo-C₅H₁₁ 367 i-C₃H₇ O cyclopentyl 368i-C₃H₇ O n-C₆H₁₃ 369 i-C₃H₇ O cyclohexyl 370 i-C₃H₇ O CF₃ 371 i-C₃H₇ Opropyn-3-yl 372 i-C₃H₇ O propen-3-yl 373 i-C₃H₇ O benzyl 374 i-C₃H₇ Ophenyl 375 i-C₃H₇ NH H 376 i-C₃H₇ NH CH₃ 377 i-C₃H₇ NH C₂H₅ 378 i-C₃H₇NH n-C₃H₇ 379 i-C₃H₇ NH i-C₃H₇ 380 i-C₃H₇ NH cyclopropyl 381 i-C₃H₇ NHn-C₄H₉ 382 i-C₃H₇ NH s-C₄H₉ 383 i-C₃H₇ NH i-C₄H₉ 384 i-C₃H₇ NH t-C₄H₉385 i-C₃H₇ NH n-C₅H₁₁ 386 i-C₃H₇ NH i-C₅H₁₁ 387 i-C₃H₇ NH neo-C₅H₁₁ 388i-C₃H₇ NH cyclopentyl 389 i-C₃H₇ NH n-C₆H₁₃ 390 i-C₃H₇ NH cyclohexyl 391i-C₃H₇ NH cyclopropyl-CH₂ 392 i-C₃H₇ NH propyn-3-yl 393 i-C₃H₇ NHpropen-3-yl 394 i-C₃H₇ NH benzyl 395 i-C₃H₇ NH phenyl 396 i-C₃H₇ NCH₃CH₃ 397 i-C₃H₇ NCH₃ C₂H₅ 398 i-C₃H₇ NCH₃ n-C₃H₇ 399 i-C₃H₇ NCH₃ i-C₃H₇400 i-C₃H₇ NCH₃ cyclopropyl 401 i-C₃H₇ NCH₃ n-C₄H₉ 402 i-C₃H₇ NCH₃s-C₄H₉ 403 i-C₃H₇ NCH₃ i-C₄H₉ 404 i-C₃H₇ NCH₃ t-C₄H₉ 405 i-C₃H₇ NCH₃n-C₅H₁₁ 406 i-C₃H₇ NCH₃ i-C₅H₁₁ 407 i-C₃H₇ NCH₃ neo-C₅H₁₁ 408 i-C₃H₇NCH₃ cyclopentyl 409 i-C₃H₇ NCH₃ n-C₆H₁₃ 410 i-C₃H₇ NCH₃ cyclohexyl 411i-C₃H₇ NCH₃ cyclopropyl-CH₂ 412 i-C₃H₇ NCH₃ propyn-3-yl 413 i-C₃H₇ NCH₃propen-3-yl 414 i-C₃H₇ NCH₃ benzyl 415 i-C₃H₇ NCH₃ phenyl 416 benzyl — H417 benzyl — CH₃ 418 benzyl — C₂H₅ 419 benzyl — n-C₃H₇ 420 benzyl —i-C₃H₇ 421 benzyl — cyclopropyl 422 benzyl — n-C₄H₉ 423 benzyl — s-C₄H₉424 benzyl — i-C₄H₉ 425 benzyl — t-C₄H₉ 426 benzyl — n-C₅H₁₁ 427 benzyl— i-C₅H₁₁ 428 benzyl — neo-C₅H₁₁ 429 benzyl — cyclopentyl 430 benzyl —n-C₆H₁₃ 431 benzyl — cyclohexyl 432 benzyl — CF₃ 433 benzyl — ethenyl434 benzyl — propen-3-yl 435 benzyl — benzyl 436 benzyl — phenyl 437benzyl O H 438 benzyl O CH₃ 439 benzyl O C₂H₅ 440 benzyl O n-C₃H₇ 441benzyl O i-C₃H₇ 442 benzyl O cyclopropyl 443 benzyl O n-C₄H₉ 444 benzylO s-C₄H₉ 445 benzyl O i-C₄H₉ 446 benzyl O t-C₄H₉ 447 benzyl O n-C₅H₁₁448 benzyl O i-C₅H₁₁ 449 benzyl O neo-C₅H₁₁ 450 benzyl O cyclopentyl 451benzyl O n-C₆H₁₃ 452 benzyl O cyclohexyl 453 benzyl O CF₃ 454 benzyl Opropyn-3-yl 455 benzyl O propen-3-yl 456 benzyl O benzyl 457 benzyl Ophenyl 458 benzyl NH H 459 benzyl NH CH₃ 460 benzyl NH C₂H₅ 461 benzylNH n-C₃H₇ 462 benzyl NH i-C₃H₇ 463 benzyl NH cyclopropyl 464 benzyl NHn-C₄H₉ 465 benzyl NH s-C₄H₉ 466 benzyl NH i-C₄H₉ 467 benzyl NH t-C₄H₉468 benzyl NH n-C₅H₁₁ 469 benzyl NH i-C₅H₁₁ 470 benzyl NH neo-C₅H₁₁ 471benzyl NH cyclopentyl 472 benzyl NH n-C₆H₁₃ 473 benzyl NH cyclohexyl 474benzyl NH cyclopropyl-CH₂ 475 benzyl NH propyn-3-yl 476 benzyl NHpropen-3-yl 477 benzyl NH benzyl 478 benzyl NH phenyl 479 benzyl NCH₃CH₃ 480 benzyl NCH₃ C₂H₅ 481 benzyl NCH₃ n-C₃H₇ 482 benzyl NCH₃ i-C₃H₇483 benzyl NCH₃ cyclopropyl 484 benzyl NCH₃ n-C₄H₉ 485 benzyl NCH₃s-C₄H₉ 486 benzyl NCH₃ i-C₄H₉ 487 benzyl NCH₃ t-C₄H₉ 488 benzyl NCH₃n-C₅H₁₁ 489 benzyl NCH₃ i-C₅H₁₁ 490 benzyl NCH₃ neo-C₅H₁₁ 491 benzylNCH₃ cyclopentyl 492 benzyl NCH₃ n-C₆H₁₃ 493 benzyl NCH₃ cyclohexyl 494benzyl NCH₃ cyclopropyl-CH₂ 495 benzyl NCH₃ propyn-3-yl 496 benzyl NCH₃propen-3-yl 497 benzyl NCH₃ benzyl 498 benzyl NCH₃ phenyl 499propen-3-yl — H 500 propen-3-yl — CH₃ 501 propen-3-yl — C₂H₅ 502propen-3-yl — n-C₃H₇ 503 propen-3-yl — i-C₃H₇ 504 propen-3-yl —cyclopropyl 505 propen-3-yl — n-C₄H₉ 506 propen-3-yl — s-C₄H₉ 507propen-3-yl — i-C₄H₉ 508 propen-3-yl — t-C₄H₉ 509 propen-3-yl — n-C₅H₁₁510 propen-3-yl — i-C₅H₁₁ 511 propen-3-yl — neo-C₅H₁₁ 512 propen-3-yl —cyclopentyl 513 propen-3-yl — n-C₆H₁₃ 514 propen-3-yl — cyclohexyl 515propen-3-yl — CF₃ 516 propen-3-yl — ethenyl 517 propen-3-yl —propen-3-yl 518 propen-3-yl — benzyl 519 propen-3-yl — phenyl 520propen-3-yl O H 521 propen-3-yl O CH₃ 522 propen-3-yl O C₂H₅ 523propen-3-yl O n-C₃H₇ 524 propen-3-yl O i-C₃H₇ 525 propen-3-yl Ocyclopropyl 526 propen-3-yl O n-C₄H₉ 527 propen-3-yl O s-C₄H₉ 528propen-3-yl O i-C₄H₉ 529 propen-3-yl O t-C₄H₉ 530 propen-3-yl O n-C₅H₁₁531 propen-3-yl O i-C₅H₁₁ 532 propen-3-yl O neo-C₅H₁₁ 533 propen-3-yl Ocyclopentyl 534 propen-3-yl O n-C₆H₁₃ 535 propen-3-yl O cyclohexyl 536propen-3-yl O CF₃ 537 propen-3-yl O propyn-3-yl 538 propen-3-yl Opropen-3-yl 539 propen-3-yl O benzyl 540 propen-3-yl O phenyl 541propen-3-yl NH H 542 propen-3-yl NH CH₃ 543 propen-3-yl NH C₂H₅ 544propen-3-yl NH n-C₃H₇ 545 propen-3-yl NH i-C₃H₇ 546 propen-3-yl NHcyclopropyl 547 propen-3-yl NH n-C₄H₉ 548 propen-3-yl NH s-C₄H₉ 549propen-3-yl NH i-C₄H₉ 550 propen-3-yl NH t-C₄H₉ 551 propen-3-yl NHn-C₅H₁₁ 552 propen-3-yl NH i-C₅H₁₁ 553 propen-3-yl NH neo-C₅H₁₁ 554propen-3-yl NH cyclopentyl 555 propen-3-yl NH n-C₆H₁₃ 556 propen-3-yl NHcyclohexyl 557 propen-3-yl NH cyclopropyl-CH₂ 558 propen-3-yl NHpropyn-3-yl 559 propen-3-yl NH propen-3-yl 560 propen-3-yl NH benzyl 561propen-3-yl NH phenyl 562 propen-3-yl NCH₃ CH₃ 563 propen-3-yl NCH₃ C₂H₅564 propen-3-yl NCH₃ n-C₃H₇ 565 propen-3-yl NCH₃ i-C₃H₇ 566 propen-3-ylNCH₃ cyclopropyl 567 propen-3-yl NCH₃ n-C₄H₉ 568 propen-3-yl NCH₃ s-C₄H₉569 propen-3-yl NCH₃ i-C₄H₉ 570 propen-3-yl NCH₃ t-C₄H₉ 571 propen-3-ylNCH₃ n-C₅H₁₁ 572 propen-3-yl NCH₃ i-C₅H₁₁ 573 propen-3-yl NCH₃ neo-C₅H₁₁574 propen-3-yl NCH₃ cyclopentyl 575 propen-3-yl NCH₃ n-C₆H₁₃ 576propen-3-yl NCH₃ cyclohexyl 577 propen-3-yl NCH₃ cyclopropyl-CH₂ 578propen-3-yl NCH₃ propyn-3-yl 579 propen-3-yl NCH₃ propen-3-yl 580propen-3-yl NCH₃ benzyl 581 propen-3-yl NCH₃ phenyl 582 H NC₂H₅ C₂H₅ 583H N-n-C₃H₇ n-C₃H₇ 584 H N—CH₂CH═CH₂ CH₂CH═CH₂ 585 H N—CH₂CH₂OH CH₂CH═CH₂586 CH₃ NC₂H₅ C₂H₅ 587 CH₃ N-n-C₃H₇ n-C₃H₇ 588 CH₃ N—CH₂CH═CH₂ CH₂CH═CH₂589 CH₃ N—CH₂CHOH CH₂CH═CH₂ 590 C₆H₅—CH₂ NC₂H₅ C₂H₅ 591 C₆H₅—CH₂N-n-C₃H₇ n-C₃H₇ 592 C₆H₅—CH₂ N—CH₂CH═CH₂ CH₂CH═CH₂ 593 C₆H₅—CH₂N—CH₂CH₂OH CH₂CH═CH₂ f) R⁴ = 4-NR^(c)—(C═O)—Ap—R^(a) 1 H — H 2 H — CH₃ 3H — C₂H₅ 4 H — n-C₃H₇ 5 H — i-C₃H₇ 6 H — cyclopropyl 7 H — n-C₄H₉ 8 H —s-C₄H₉ 9 H — i-C₄H₉ 10 H — t-C₄H₉ 11 H — n-C₅H₁₁ 12 H — i-C₅H₁₁ 13 H —neo-C₅H₁₁ 14 H — cyclopentyl 15 H — n-C₆H₁₃ 16 H — cyclohexyl 17 H — CF₃18 H — ethenyl 19 H — propen-3-yl 20 H — benzyl 21 H — phenyl 22 H O H23 H O CH₃ 24 H O C₂H₅ 25 H O n-C₃H₇ 26 H O i-C₃H₇ 27 H O cyclopropyl 28H O n-C₄H₉ 29 H O s-C₄H₉ 30 H O i-C₄H₉ 31 H O t-C₄H₉ 32 H O n-C₅H₁₁ 33 HO i-C₅H₁₁ 34 H O neo-C₅H₁₁ 35 H O cyclopentyl 36 H O n-C₆H₁₃ 37 H Ocyclohexyl 38 H O CF₃ 39 H O propyn-3-yl 40 H O propen-3-yl 41 H Obenzyl 42 H O phenyl 43 H NH H 44 H NH CH₃ 45 H NH C₂H₅ 46 H NH n-C₃H₇47 H NH i-C₃H₇ 48 H NH cyclopropyl 49 H NH n-C₄H₉ 50 H NH s-C₄H₉ 51 H NHi-C₄H₉ 52 H NH t-C₄H₉ 53 H NH n-C₅H₁₁ 54 H NH i-C₅H₁₁ 55 H NH neo-C₅H₁₁56 H NH cyclopentyl 57 H NH n-C₆H₁₃ 58 H NH cyclohexyl 59 H NHcyclopropyl-CH₂ 60 H NH propyn-3-yl 61 H NH propen-3-yl 62 H NH benzyl63 H NH phenyl 64 H NCH₃ CH₃ 65 H NCH₃ C₂H₅ 66 H NCH₃ n-C₃H₇ 67 H NCH₃i-C₃H₇ 68 H NCH₃ cyclopropyl 69 H NCH₃ n-C₄H₉ 70 H NCH₃ s-C₄H₉ 71 H NCH₃i-C₄H₉ 72 H NCH₃ t-C₄H₉ 73 H NCH₃ n-C₅H₁₁ 74 H NCH₃ i-C₅H₁₁ 75 H NCH₃neo-C₅H₁₁ 76 H NCH₃ cyclopentyl 77 H NCH₃ n-C₆H₁₃ 78 H NCH₃ cyclohexyl79 H NCH₃ cyclopropyl-CH₂ 80 H NCH₃ propyn-3-yl 81 H NCH₃ propen-3-yl 82H NCH₃ benzyl 83 H NCH₃ phenyl 84 CH₃ — H 85 CH₃ — CH₃ 86 CH₃ — C₂H₅ 87CH₃ — n-C₃H₇ 88 CH₃ — i-C₃H₇ 89 CH₃ — cyclopropyl 90 CH₃ — n-C₄H₉ 91 CH₃— s-C₄H₉ 92 CH₃ — i-C₄H₉ 93 CH₃ — t-C₄H₉ 94 CH₃ — n-C₅H₁₁ 95 CH₃ —i-C₅H₁₁ 96 CH₃ — neo-C₅H₁₁ 97 CH₃ — cyclopentyl 98 CH₃ — n-C₆H₁₃ 99 CH₃— cyclohexyl 100 CH₃ — CF₃ 101 CH₃ — ethenyl 102 CH₃ — propen-3-yl 103CH₃ — benzyl 104 CH₃ — phenyl 105 CH₃ O H 106 CH₃ O CH₃ 107 CH₃ O C₂H₅108 CH₃ O n-C₃H₇ 109 CH₃ O i-C₃H₇ 110 CH₃ O cyclopropyl 111 CH₃ O n-C₄H₉112 CH₃ O s-C₄H₉ 113 CH₃ O i-C₄H₉ 114 CH₃ O t-C₄H₉ 115 CH₃ O n-C₅H₁₁ 116CH₃ O i-C₅H₁₁ 117 CH₃ O neo-C₅H₁₁ 118 CH₃ O cyclopentyl 119 CH₃ On-C₆H₁₃ 120 CH₃ O cyclohexyl 121 CH₃ O CF₃ 122 CH₃ O propyn-3-yl 123 CH₃O propen-3-yl 124 CH₃ O benzyl 125 CH₃ O phenyl 126 CH₃ NH H 127 CH₃ NHCH₃ 128 CH₃ NH C₂H₅ 129 CH₃ NH n-C₃H₇ 130 CH₃ NH i-C₃H₇ 131 CH₃ NHcyclopropyl 132 CH₃ NH n-C₄H₉ 133 CH₃ NH s-C₄H₉ 134 CH₃ NH i-C₄H₉ 135CH₃ NH t-C₄H₉ 136 CH₃ NH n-C₅H₁₁ 137 CH₃ NH i-C₅H₁₁ 138 CH₃ NH neo-C₅H₁₁139 CH₃ NH cyclopentyl 140 CH₃ NH n-C₆H₁₃ 141 CH₃ NH cyclohexyl 142 CH₃NH cyclopropyl-CH₂ 143 CH₃ NH propyn-3-yl 144 CH₃ NH propen-3-yl 145 CH₃NH benzyl 146 CH₃ NH phenyl 147 CH₃ NCH₃ CH₃ 148 CH₃ NCH₃ C₂H₅ 149 CH₃NCH₃ n-C₃H₇ 150 CH₃ NCH₃ i-C₃H₇ 151 CH₃ NCH₃ cyclopropyl 152 CH₃ NCH₃n-C₄H₉ 153 CH₃ NCH₃ s-C₄H₉ 154 CH₃ NCH₃ i-C₄H₉ 155 CH₃ NCH₃ t-C₄H₉ 156CH₃ NCH₃ n-C₅H₁₁ 157 CH₃ NCH₃ i-C₅H₁₁ 158 CH₃ NCH₃ neo-C₅H₁₁ 159 CH₃NCH₃ cyclopentyl 160 CH₃ NCH₃ n-C₆H₁₃ 161 CH₃ NCH₃ cyclohexyl 162 CH₃NCH₃ cyclopropyl-CH₂ 163 CH₃ NCH₃ propyn-3-yl 164 CH₃ NCH₃ propen-3-yl165 CH₃ NCH₃ benzyl 166 CH₃ NCH₃ phenyl 167 C₂H₅ — H 168 C₂H₅ — CH₃ 169C₂H₅ — C₂H₅ 170 C₂H₅ — n-C₃H₇ 171 C₂H₅ — i-C₃H₇ 172 C₂H₅ — cyclopropyl173 C₂H₅ — n-C₄H₉ 174 C₂H₅ — s-C₄H₉ 175 C₂H₅ — i-C₄H₉ 176 C₂H₅ — t-C₄H₉177 C₂H₅ — n-C₅H₁₁ 178 C₂H₅ — i-C₅H₁₁ 179 C₂H₅ — neo-C₅H₁₁ 180 C₂H₅ —cyclopentyl 181 C₂H₅ — n-C₆H₁₃ 182 C₂H₅ — cyclohexyl 183 C₂H₅ — CF₃ 184C₂H₅ — ethenyl 185 C₂H₅ — propen-3-yl 186 C₂H₅ — benzyl 187 C₂H₅ —phenyl 188 C₂H₅ O H 189 C₂H₅ O CH₃ 190 C₂H₅ O C₂H₅ 191 C₂H₅ O n-C₃H₇ 192C₂H₅ O i-C₃H₇ 193 C₂H₅ O cyclopropyl 194 C₂H₅ O n-C₄H₉ 195 C₂H₅ O s-C₄H₉196 C₂H₅ O i-C₄H₉ 197 C₂H₅ O t-C₄H₉ 198 C₂H₅ O n-C₅H₁₁ 199 C₂H₅ Oi-C₅H₁₁ 200 C₂H₅ O neo-C₅H₁₁ 201 C₂H₅ O cyclopentyl 202 C₂H₅ O n-C₆H₁₃203 C₂H₅ O cyclohexyl 204 C₂H₅ O CF₃ 205 C₂H₅ O propyn-3-yl 206 C₂H₅ Opropen-3-yl 207 C₂H₅ O benzyl 208 C₂H₅ O phenyl 209 C₂H₅ NH H 210 C₂H₅NH CH₃ 211 C₂H₅ NH C₂H₅ 212 C₂H₅ NH n-C₃H₇ 213 C₂H₅ NH i-C₃H₇ 214 C₂H₅NH cyclopropyl 215 C₂H₅ NH n-C₄H₉ 216 C₂H₅ NH s-C₄H₉ 217 C₂H₅ NH i-C₄H₉218 C₂H₅ NH t-C₄H₉ 219 C₂H₅ NH n-C₅H₁₁ 220 C₂H₅ NH i-C₅H₁₁ 221 C₂H₅ NHneo-C₅H₁₁ 222 C₂H₅ NH cyclopentyl 223 C₂H₅ NH n-C₆H₁₃ 224 C₂H₅ NHcyclohexyl 225 C₂H₅ NH cyclopropyl-CH₂ 226 C₂H₅ NH propyn-3-yl 227 C₂H₅NH propen-3-yl 228 C₂H₅ NH benzyl 229 C₂H₅ NH phenyl 230 C₂H₅ NCH₃ CH₃231 C₂H₅ NCH₃ C₂H₅ 232 C₂H₅ NCH₃ n-C₃H₇ 233 C₂H₅ NCH₃ i-C₃H₇ 234 C₂H₅NCH₃ cyclopropyl 235 C₂H₅ NCH₃ n-C₄H₉ 236 C₂H₅ NCH₃ s-C₄H₉ 237 C₂H₅ NCH₃i-C₄H₉ 238 C₂H₅ NCH₃ t-C₄H₉ 239 C₂H₅ NCH₃ n-C₅H₁₁ 240 C₂H₅ NCH₃ i-C₅H₁₁241 C₂H₅ NCH₃ neo-C₅H₁₁ 242 C₂H₅ NCH₃ cyclopentyl 243 C₂H₅ NCH₃ n-C₆H₁₃244 C₂H₅ NCH₃ cyclohexyl 245 C₂H₅ NCH₃ cyclopropyl-CH₂ 246 C₂H₅ NCH₃propyn-3-yl 247 C₂H₅ NCH₃ propen-3-yl 248 C₂H₅ NCH₃ benzyl 249 C₂H₅ NCH₃phenyl 250 n-C₃H₇ — H 251 n-C₃H₇ — CH₃ 252 n-C₃H₇ — C₂H₅ 253 n-C₃H₇ —n-C₃H₇ 254 n-C₃H₇ — i-C₃H₇ 255 n-C₃H₇ — cyclopropyl 256 n-C₃H₇ — n-C₄H₉257 n-C₃H₇ — s-C₄H₉ 258 n-C₃H₇ — i-C₄H₉ 259 n-C₃H₇ — t-C₄H₉ 260 n-C₃H₇ —n-C₅H₁₁ 261 n-C₃H₇ — i-C₅H₁₁ 262 n-C₃H₇ — neo-C₅H₁₁ 263 n-C₃H₇ —cyclopentyl 264 n-C₃H₇ — n-C₆H₁₃ 265 n-C₃H₇ — cyclohexyl 266 n-C₃H₇ —CF₃ 267 n-C₃H₇ — ethenyl 268 n-C₃H₇ — propen-3-yl 269 n-C₃H₇ — benzyl270 n-C₃H₇ — phenyl 271 n-C₃H₇ O H 272 n-C₃H₇ O CH₃ 273 n-C₃H₇ O C₂H₅274 n-C₃H₇ O n-C₃H₇ 275 n-C₃H₇ O i-C₃H₇ 276 n-C₃H₇ O cyclopropyl 277n-C₃H₇ O n-C₄H₉ 278 n-C₃H₇ O s-C₄H₉ 279 n-C₃H₇ O i-C₄H₉ 280 n-C₃H₇ Ot-C₄H₉ 281 n-C₃H₇ O n-C₅H₁₁ 282 n-C₃H₇ O i-C₅H₁₁ 283 n-C₃H₇ O neo-C₅H₁₁284 n-C₃H₇ O cyclopentyl 285 n-C₃H₇ O n-C₆H₁₃ 286 n-C₃H₇ O cyclohexyl287 n-C₃H₇ O CF₃ 288 n-C₃H₇ O propyn-3-yl 289 n-C₃H₇ O propen-3-yl 290n-C₃H₇ O benzyl 291 n-C₃H₇ O phenyl 292 n-C₃H₇ NH H 293 n-C₃H₇ NH CH₃294 n-C₃H₇ NH C₂H₅ 295 n-C₃H₇ NH n-C₃H₇ 296 n-C₃H₇ NH i-C₃H₇ 297 n-C₃H₇NH cyclopropyl 298 n-C₃H₇ NH n-C₄H₉ 299 n-C₃H₇ NH s-C₄H₉ 300 n-C₃H₇ NHi-C₄H₉ 301 n-C₃H₇ NH t-C₄H₉ 302 n-C₃H₇ NH n-C₅H₁₁ 303 n-C₃H₇ NH i-C₅H₁₁304 n-C₃H₇ NH neo-C₅H₁₁ 305 n-C₃H₇ NH cyclopentyl 306 n-C₃H₇ NH n-C₆H₁₃307 n-C₃H₇ NH cyclohexyl 308 n-C₃H₇ NH cyclopropyl-CH₂ 309 n-C₃H₇ NHpropyn-3-yl 310 n-C₃H₇ NH propen-3-yl 311 n-C₃H₇ NH benzyl 312 n-C₃H₇ NHphenyl 313 n-C₃H₇ NCH₃ CH₃ 314 n-C₃H₇ NCH₃ C₂H₅ 315 n-C₃H₇ NCH₃ n-C₃H₇316 n-C₃H₇ NCH₃ i-C₃H₇ 317 n-C₃H₇ NCH₃ cyclopropyl 318 n-C₃H₇ NCH₃n-C₄H₉ 319 n-C₃H₇ NCH₃ s-C₄H₉ 320 n-C₃H₇ NCH₃ i-C₄H₉ 321 n-C₃H₇ NCH₃t-C₄H₉ 322 n-C₃H₇ NCH₃ n-C₅H₁₁ 323 n-C₃H₇ NCH₃ i-C₅H₁₁ 324 n-C₃H₇ NCH₃neo-C₅H₁₁ 325 n-C₃H₇ NCH₃ cyclopentyl 326 n-C₃H₇ NCH₃ n-C₆H₁₃ 327 n-C₃H₇NCH₃ cyclohexyl 328 n-C₃H₇ NCH₃ cyclopropyl-CH₂ 329 n-C₃H₇ NCH₃propyn-3-yl 330 n-C₃H₇ NCH₃ propen-3-yl 331 n-C₃H₇ NCH₃ benzyl 332n-C₃H₇ NCH₃ phenyl 333 i-C₃H₇ — H 334 i-C₃H₇ — CH₃ 335 i-C₃H₇ — C₂H₅ 336i-C₃H₇ — n-C₃H₇ 337 i-C₃H₇ — i-C₃H₇ 338 i-C₃H₇ — cyclopropyl 339 i-C₃H₇— n-C₄H₉ 340 i-C₃H₇ — s-C₄H₉ 341 i-C₃H₇ — i-C₄H₉ 342 i-C₃H₇ — t-C₄H₉ 343i-C₃H₇ — n-C₅H₁₁ 344 i-C₃H₇ — i-C₅H₁₁ 345 i-C₃H₇ — neo-C₅H₁₁ 346 i-C₃H₇— cyclopentyl 347 i-C₃H₇ — n-C₆H₁₃ 348 i-C₃H₇ — cyclohexyl 349 i-C₃H₇ —CF₃ 350 i-C₃H₇ — ethenyl 351 i-C₃H₇ — propen-3-yl 352 i-C₃H₇ — benzyl353 i-C₃H₇ — phenyl 354 i-C₃H₇ O H 355 i-C₃H₇ O CH₃ 356 i-C₃H₇ O C₂H₅357 i-C₃H₇ O n-C₃H₇ 358 i-C₃H₇ O i-C₃H₇ 359 i-C₃H₇ O cyclopropyl 360i-C₃H₇ O n-C₄H₉ 361 i-C₃H₇ O s-C₄H₉ 362 i-C₃H₇ O i-C₄H₉ 363 i-C₃H₇ Ot-C₄H₉ 364 i-C₃H₇ O n-C₅H₁₁ 365 i-C₃H₇ O i-C₅H₁₁ 366 i-C₃H₇ O neo-C₅H₁₁367 i-C₃H₇ O cyclopentyl 368 i-C₃H₇ O n-C₆H₁₃ 369 i-C₃H₇ O cyclohexyl370 i-C₃H₇ O CF₃ 371 i-C₃H₇ O propyn-3-yl 372 i-C₃H₇ O propen-3-yl 373i-C₃H₇ O benzyl 374 i-C₃H₇ O phenyl 375 i-C₃H₇ NH H 376 i-C₃H₇ NH CH₃377 i-C₃H₇ NH C₂H₅ 378 i-C₃H₇ NH n-C₃H₇ 379 i-C₃H₇ NH i-C₃H₇ 380 i-C₃H₇NH cyclopropyl 381 i-C₃H₇ NH n-C₄H₉ 382 i-C₃H₇ NH s-C₄H₉ 383 i-C₃H₇ NHi-C₄H₉ 384 i-C₃H₇ NH t-C₄H₉ 385 i-C₃H₇ NH n-C₅H₁₁ 386 i-C₃H₇ NH i-C₅H₁₁387 i-C₃H₇ NH neo-C₅H₁₁ 388 i-C₃H₇ NH cyclopentyl 389 i-C₃H₇ NH n-C₆H₁₃390 i-C₃H₇ NH cyclohexyl 391 i-C₃H₇ NH cyclopropyl-CH₂ 392 i-C₃H₇ NHpropyn-3-yl 393 i-C₃H₇ NH propen-3-yl 394 i-C₃H₇ NH benzyl 395 i-C₃H₇ NHphenyl 396 i-C₃H₇ NCH₃ CH₃ 397 i-C₃H₇ NCH₃ C₂H₅ 398 i-C₃H₇ NCH₃ n-C₃H₇399 i-C₃H₇ NCH₃ i-C₃H₇ 400 i-C₃H₇ NCH₃ cyclopropyl 401 i-C₃H₇ NCH₃n-C₄H₉ 402 i-C₃H₇ NCH₃ s-C₄H₉ 403 i-C₃H₇ NCH₃ i-C₄H₉ 404 i-C₃H₇ NCH₃t-C₄H₉ 405 i-C₃H₇ NCH₃ n-C₅H₁₁ 406 i-C₃H₇ NCH₃ i-C₅H₁₁ 407 i-C₃H₇ NCH₃neo-C₅H₁₁ 408 i-C₃H₇ NCH₃ cyclopentyl 409 i-C₃H₇ NCH₃ n-C₆H₁₃ 410 i-C₃H₇NCH₃ cyclohexyl 411 i-C₃H₇ NCH₃ cyclopropyl-CH₂ 412 i-C₃H₇ NCH₃propyn-3-yl 413 i-C₃H₇ NCH₃ propen-3-yl 414 i-C₃H₇ NCH₃ benzyl 415i-C₃H₇ NCH₃ phenyl 416 benzyl — H 417 benzyl — CH₃ 418 benzyl — C₂H₅ 419benzyl — n-C₃H₇ 420 benzyl — i-C₃H₇ 421 benzyl — cyclopropyl 422 benzyl— n-C₄H₉ 423 benzyl — s-C₄H₉ 424 benzyl — i-C₄H₉ 425 benzyl — t-C₄H₉ 426benzyl — n-C₅H₁₁ 427 benzyl — i-C₅H₁₁ 428 benzyl — neo-C₅H₁₁ 429 benzyl— cyclopentyl 430 benzyl — n-C₆H₁₃ 431 benzyl — cyclohexyl 432 benzyl —CF₃ 433 benzyl — ethenyl 434 benzyl — propen-3-yl 435 benzyl — benzyl436 benzyl — phenyl 437 benzyl O H 438 benzyl O CH₃ 439 benzyl O C₂H₅440 benzyl O n-C₃H₇ 441 benzyl O i-C₃H₇ 442 benzyl O cyclopropyl 443benzyl O n-C₄H₉ 444 benzyl O s-C₄H₉ 445 benzyl O i-C₄H₉ 446 benzyl Ot-C₄H₉ 447 benzyl O n-C₅H₁₁ 448 benzyl O i-C₅H₁₁ 449 benzyl O neo-C₅H₁₁450 benzyl O cyclopentyl 451 benzyl O n-C₆H₁₃ 452 benzyl O cyclohexyl453 benzyl O CF₃ 454 benzyl O propyn-3-yl 455 benzyl O propen-3-yl 456benzyl O benzyl 457 benzyl O phenyl 458 benzyl NH H 459 benzyl NH CH₃460 benzyl NH C₂H₅ 461 benzyl NH n-C₃H₇ 462 benzyl NH i-C₃H₇ 463 benzylNH cyclopropyl 464 benzyl NH n-C₄H₉ 465 benzyl NH s-C₄H₉ 466 benzyl NHi-C₄H₉ 467 benzyl NH t-C₄H₉ 468 benzyl NH n-C₅H₁₁ 469 benzyl NH i-C₅H₁₁470 benzyl NH neo-C₅H₁₁ 471 benzyl NH cyclopentyl 472 benzyl NH n-C₆H₁₃473 benzyl NH cyclohexyl 474 benzyl NH cyclopropyl-CH₂ 475 benzyl NHpropyn-3-yl 476 benzyl NH propen-3-yl 477 benzyl NH benzyl 478 benzyl NHphenyl 479 benzyl NCH₃ CH₃ 480 benzyl NCH₃ C₂H₅ 481 benzyl NCH₃ n-C₃H₇482 benzyl NCH₃ i-C₃H₇ 483 benzyl NCH₃ cyclopropyl 484 benzyl NCH₃n-C₄H₉ 485 benzyl NCH₃ s-C₄H₉ 486 benzyl NCH₃ i-C₄H₉ 487 benzyl NCH₃t-C₄H₉ 488 benzyl NCH₃ n-C₅H₁₁ 489 benzyl NCH₃ i-C₅H₁₁ 490 benzyl NCH₃neo-C₅H₁₁ 491 benzyl NCH₃ cyclopentyl 492 benzyl NCH₃ n-C₆H₁₃ 493 benzylNCH₃ cyclohexyl 494 benzyl NCH₃ cyclopropyl-CH₂ 495 benzyl NCH₃propyn-3-yl 496 benzyl NCH₃ propen-3-yl 497 benzyl NCH₃ benzyl 498benzyl NCH₃ phenyl 499 propen-3-yl — H 500 propen-3-yl — CH₃ 501propen-3-yl — C₂H₅ 502 propen-3-yl — n-C₃H₇ 503 propen-3-yl — i-C₃H₇ 504propen-3-yl — cyclopropyl 505 propen-3-yl — n-C₄H₉ 506 propen-3-yl —s-C₄H₉ 507 propen-3-yl — i-C₄H₉ 508 propen-3-yl — t-C₄H₉ 509 propen-3-yl— n-C₅H₁₁ 510 propen-3-yl — i-C₅H₁₁ 511 propen-3-yl — neo-C₅H₁₁ 512propen-3-yl — cyclopentyl 513 propen-3-yl — n-C₆H₁₃ 514 propen-3-yl —cyclohexyl 515 propen-3-yl — CF₃ 516 propen-3-yl — ethenyl 517propen-3-yl — propen-3-yl 518 propen-3-yl — benzyl 519 propen-3-yl —phenyl 520 propen-3-yl O H 521 propen-3-yl O CH₃ 522 propen-3-yl O C₂H₅523 propen-3-yl O n-C₃H₇ 524 propen-3-yl O i-C₃H₇ 525 propen-3-yl Ocyclopropyl 526 propen-3-yl O n-C₄H₉ 527 propen-3-yl O s-C₄H₉ 528propen-3-yl O i-C₄H₉ 529 propen-3-yl O t-C₄H₉ 530 propen-3-yl O n-C₅H₁₁531 propen-3-yl O i-C₅H₁₁ 532 propen-3-yl O neo-C₅H₁₁ 533 propen-3-yl Ocyclopentyl 534 propen-3-yl O n-C₆H₁₃ 535 propen-3-yl O cyclohexyl 536propen-3-yl O CF₃ 537 propen-3-yl O propyn-3-yl 538 propen-3-yl Opropen-3-yl 539 propen-3-yl O benzyl 540 propen-3-yl O phenyl 541propen-3-yl NH H 542 propen-3-yl NH CH₃ 543 propen-3-yl NH C₂H₅ 544propen-3-yl NH n-C₃H₇ 545 propen-3-yl NH i-C₃H₇ 546 propen-3-yl NHcyclopropyl 547 propen-3-yl NH n-C₄H₉ 548 propen-3-yl NH s-C₄H₉ 549propen-3-yl NH i-C₄H₉ 550 propen-3-yl NH t-C₄H₉ 551 propen-3-yl NHn-C₅H₁₁ 552 propen-3-yl NH i-C₅H₁₁ 553 propen-3-yl NH neo-C₅H₁₁ 554propen-3-yl NH cyclopentyl 555 propen-3-yl NH n-C₆H₁₃ 556 propen-3-yl NHcyclohexyl 557 propen-3-yl NH cyclopropyl-CH₂ 558 propen-3-yl NHpropyn-3-yl 559 propen-3-yl NH propen-3-yl 560 propen-3-yl NH benzyl 561propen-3-yl NH phenyl 562 propen-3-yl NCH₃ CH₃ 563 propen-3-yl NCH₃ C₂H₅564 propen-3-yl NCH₃ n-C₃H₇ 565 propen-3-yl NCH₃ i-C₃H₇ 566 propen-3-ylNCH₃ cyclopropyl 567 propen-3-yl NCH₃ n-C₄H₉ 568 propen-3-yl NCH₃ s-C₄H₉569 propen-3-yl NCH₃ i-C₄H₉ 570 propen-3-yl NCH₃ t-C₄H₉ 571 propen-3-ylNCH₃ n-C₅H₁₁ 572 propen-3-yl NCH₃ i-C₅H₁₁ 573 propen-3-yl NCH₃ neo-C₅H₁₁574 propen-3-yl NCH₃ cyclopentyl 575 propen-3-yl NCH₃ n-C₆H₁₃ 576propen-3-yl NCH₃ cyclohexyl 577 propen-3-yl NCH₃ cyclopropyl-CH₂ 578propen-3-yl NCH₃ propyn-3-yl 579 propen-3-yl NCH₃ propen-3-yl 580propen-3-yl NCH₃ benzyl 581 propen-3-yl NCH₃ phenyl 582 H NC₂H₅ C₂H₅ 583H N—N—C₃H₇ n-C₃H₇ 584 H N—CH₂CH═CH₂ CH₂CH═CH₂ 585 H N—CH₂CH₂OH CH₂CH═CH₂586 CH₃ NC₂H₅ C₂H₅ 587 CH₃ N-n-C₃H₇ n-C₃H₇ 588 CH₃ N—CH₂CH═CH₂ CH₂CH═CH₂589 CH₃ N—CH₂CHOH CH₂CH═CH₂ 590 C₆H₅—CH₂ NC₂H₅ C₂H₅ 591 C₆H₅—CH₂N-n-C₃H₇ n-C₃H₇ 592 C₆H₅—CH₂ N—CH₂CH═CH₂ CH₂CH═CH₂ 593 C₆H₅—CH₂N—CH₂CH₂OH CH₂CH═CH₂ No. R^(a) R^(b) g) R⁴ = 3-O(C═O)—NR^(a)R^(b) 1 H H2 H CH₃ 3 H C₂H₅ 4 H n-C₃H₇ 5 H i-C₃H₇ 6 H cyclopropyl 7 H n-C₄H₉ 8 Hs-C₄H₉ 9 H i-C₄H₉ 10 H t-C₄H₉ 11 H n-C₅H₁₁ 12 H i-C₅H₁₁ 13 H neo-C₅H₁₁14 H cyclopentyl 15 H n-C₆H₁₃ 16 H cyclohexyl 17 H cyclopropyl-CH₂ 18 Hpropyn-3-yl 19 H propen-3-yl 20 H benzyl 21 H phenyl 22 CH₃ CH₃ 23 CH₃C₂H₅ 24 CH₃ n-C₃H₇ 25 CH₃ i-C₃H₇ 26 CH₃ cyclopropyl 27 CH₃ n-C₄H₉ 28 CH₃s-C₄H₉ 29 CH₃ i-C₄H₉ 30 CH₃ t-C₄H₉ 31 CH₃ n-C₅H₁₁ 32 CH₃ i-C₅H₁₁ 33 CH₃neo-C₅H₁₁ 34 CH₃ cyclopentyl 35 CH₃ n-C₆H₁₃ 36 CH₃ cyclohexyl 37 CH₃cyclopropyl-CH₂ 38 CH₃ propyn-3-yl 39 CH₃ propen-3-yl 40 CH₃ benzyl 41CH₃ phenyl 42 C₂H₅ C₂H₅ 43 C₂H₅ n-C₃H₇ 44 C₂H₅ i-C₃H₇ 45 C₂H₅cyclopropyl 46 C₂H₅ n-C₄H₉ 47 C₂H₅ s-C₄H₉ 48 C₂H₅ i-C₄H₉ 49 C₂H₅ t-C₄H₉50 C₂H₅ n-C₅H₁₁ 51 C₂H₅ i-C₅H₁₁ 52 C₂H₅ neo-C₅H₁₁ 53 C₂H₅ cyclopentyl 54C₂H₅ n-C₆H₁₃ 55 C₂H₅ cyclohexyl 56 C₂H₅ cyclopropyl-CH₂ 57 C₂H₅propyn-3-yl 58 C₂H₅ propen-3-yl 59 C₂H₅ benzyl 60 C₂H₅ phenyl 61propen-3-yl propen-3-yl 62 propyn-3-yl propyn-3-yl 63 CH₂CH₂OH CH₂CH═CH₂64 t-C₄H₉ t-C₄H₉ 65 i-C₃H₇ i-C₃H₇ 66 n-C₃H₇ 4-Cl—C₆H₄—CH₂ h) R⁴ =4-O(C═O)—No^(a)R^(b) 67 H H 68 H CH₃ 69 H C₂H₅ 70 H n-C₃H₇ 71 H i-C₃H₇72 H cyclopropyl 73 H n-C₄H₉ 74 H s-C₄H₉ 75 H i-C₄H₉ 76 H t-C₄H₉ 77 Hn-C₅H₁₁ 78 H i-C₅H₁₁ 79 H neo-C₅H₁₁ 80 H cyclopentyl 81 H n-C₆H₁₃ 82 Hcyclohexyl 83 H cyclopropyl-CH₂ 84 H propyn-3-yl 85 H propen-3-yl 86 Hbenzyl 87 H phenyl 88 CH₃ CH₃ 89 CH₃ C₂H₅ 90 CH₃ n-C₃H₇ 91 CH₃ i-C₃H₇ 92CH₃ cyclopropyl 93 CH₃ n-C₄H₉ 94 CH₃ s-C₄H₉ 95 CH₃ i-C₄H₉ 96 CH₃ t-C₄H₉97 CH₃ n-C₅H₁₁ 98 CH₃ i-C₅H₁₁ 99 CH₃ neo-C₅H₁₁ 100 CH₃ cyclopentyl 101CH₃ n-C₆H₁₃ 102 CH₃ cyclohexyl 103 CH₃ cyclopropyl-CH₂ 104 CH₃propyn-3-yl 105 CH₃ propen-3-yl 106 CH₃ benzyl 107 CH₃ phenyl 108 C₂H₅C₂H₅ 109 C₂H₅ n-C₃H₇ 110 C₂H₅ i-C₃H₇ 111 C₂H₅ cyclopropyl 112 C₂H₅n-C₄H₉ 113 C₂H₅ s-C₄H₉ 114 C₂H₅ i-C₄H₉ 115 C₂H₅ t-C₄H₉ 116 C₂H₅ n-C₅H₁₁117 C₂H₅ i-C₅H₁₁ 118 C₂H₅ neo-C₅H₁₁ 119 C₂H₅ cyclopentyl 120 C₂H₅n-C₆H₁₃ 121 C₂H₅ cyclohexyl 122 C₂H₅ cyclopropyl-CH₂ 123 C₂H₅propyn-3-yl 124 C₂H₅ propen-3-yl 125 C₂H₅ benzyl 126 C₂H₅ phenyl 127propen-3-yl propen-3-yl 128 propyn-3-yl propyn-3-yl 129 CH₂CH₂OHCH₂CH═CH₂ 130 t-C₄H₉ t-C₄H₉ 131 i-C₃H₇ i-C₃H₇ 132 n-C₃H₇ 4-Cl—C₆H₄—CH₂No. R^(c) R^(d) i) R⁴ = 3-N(R^(c))—OR^(d) 133 CO₂CH₃ H 134 CO₂CH₃ CH₃135 CO₂CH₃ C₂H₅ 136 CO₂CH₃ n-C₃H₇ 137 CO₂CH₃ i-C₃H₇ 138 CO₂CH₃cyclopropyl 139 CO₂CH₃ n-C₄H₉ 140 CO₂CH₃ s-C₄H₉ 141 CO₂CH₃ i-C₄H₉ 142CO₂CH₃ t-C₄H₉ 143 CO₂CH₃ n-C₅H₁₁ 144 CO₂CH₃ i-C₅H₁₁ 145 CO₂CH₃ neo-C₅H₁₁146 CO₂CH₃ cyclopentyl 147 CO₂CH₃ n-C₆H₁₃ 148 CO₂CH₃ cyclohexyl 149CO₂CH₃ cyclopropyl-CH₂ 150 CO₂CH₃ propyn-3-yl 151 CO₂CH₃ propen-3-yl 152CO₂CH₃ benzyl 153 CO₂CH₃ CH₂CH₂—OCH₃ 154 CO₂CH₂CH₃ H 155 CO₂CH₂CH₃ CH₃156 CO₂CH₂CH₃ C₂H₅ 157 CO₂CH₂CH₃ n-C₃H₇ 158 CO₂CH₂CH₃ i-C₃H₇ 159CO₂CH₂CH₃ cyclopropyl 160 CO₂CH₂CH₃ n-C₄H₉ 161 CO₂CH₂CH₃ s-C₄H₉ 162CO₂CH₂CH₃ i-C₄H₉ 163 CO₂CH₂CH₃ t-C₄H₉ 164 CO₂CH₂CH₃ n-C₅H₁₁ 165CO₂CH₂CH₃ i-C₅H₁₁ 166 CO₂CH₂CH₃ neo-C₅H₁₁ 167 CO₂CH₂CH₃ cyclopentyl 168CO₂CH₂CH₃ n-C₆H₁₃ 169 CO₂CH₂CH₃ cyclohexyl 170 CO₂CH₂CH₃ cyclopropyl-CH₂171 CO₂CH₂CH₃ propyn-3-yl 172 CO₂CH₂CH₃ propen-3-yl 173 CO₂CH₂CH₃ benzyl174 CO₂CH₂CH₃ CH₂CH₂—OCH₃ 175 CO₂CH(CH₃)₂ H 176 CO₂CH(CH₃)₂ CH₃ 177CO₂CH(CH₃)₂ C₂H₅ 178 CO₂CH(CH₃)₂ n-C₃H₇ 179 CO₂CH(CH₃)₂ i-C₃H₇ 180CO₂CH(CH₃)₂ cyclopropyl 181 CO₂CH(CH₃)₂ n-C₄H₉ 182 CO₂CH(CH₃)₂ s-C₄H₉183 CO₂CH(CH₃)₂ i-C₄H₉ 184 CO₂CH(CH₃)₂ t-C₄H₉ 185 CO₂CH(CH₃)₂ n-C₅H₁₁186 CO₂CH(CH₃)₂ i-C₅H₁₁ 187 CO₂CH(CH₃)₂ neo-C₅H₁₁ 188 CO₂CH(CH₃)₂cyclopentyl 189 CO₂C(CH₃)₃ n-C₆H₁₃ 190 CO₂CH(CH₃)₂ cyclohexyl 191CO₂CH(CH₃)₂ cyclopropyl-CH₂ 192 CO₂CH(CH₃)₂ propyn-3-yl 193 CO₂CH(CH₃)₂propen-3-yl 194 CO₂CH(CH₃)₂ benzyl 195 CO₂CH(CH₃)₂ CH₂CH₂—OCH₃ 196CO₂C(CH₃)₃ H 197 CO₂C(CH₃)₃ CH₃ 198 CO₂C(CH₃)₃ C₂H₅ 199 CO₂C(CH₃)₃n-C₃H₇ 200 CO₂C(CH₃)₃ i-C₃H₇ 201 CO₂C(CH₃)₃ cyclopropyl 202 CO₂C(CH₃)₃n-C₄H₉ 203 CO₂C(CH₃)₃ s-C₄H₉ 204 CO₂C(CH₃)₃ i-C₄H₉ 205 CO₂C(CH₃)₃ t-C₄H₉206 CO₂C(CH₃)₃ n-C₅H₁₁ 207 CO₂C(CH₃)₃ i-C₅H₁₁ 208 CO₂C(CH₃)₃ neo-C₅H₁₁209 CO₂C(CH₃)₃ cyclopentyl 210 CO₂C(CH₃)₃ n-C₆H₁₃ 211 CO₂C(CH₃)₃cyclohexyl 212 CO₂C(CH₃)₃ cyclopropyl-CH₂ 213 CO₂C(CH₃)₃ propyn-3-yl 214CO₂C(CH₃)₃ propen-3-yl 215 CO₂C(CH₃)₃ benzyl 216 CO₂C(CH₃)₃ CH₂CH₂—OCH₃217 CH₃ H 218 CH₃ CH₃ 219 CH₃ C₂H₅ 220 CH₃ n-C₃H₇ 221 CH₃ i-C₃H₇ 222 CH₃cyclopropyl 223 CH₃ n-C₄H₉ 224 CH₃ s-C₄H₉ 225 CH₃ i-C₄H₉ 226 CH₃ t-C₄H₉227 CH₃ n-C₅H₁₁ 228 CH₃ i-C₅H₁₁ 229 CH₃ neo-C₅H₁₁ 230 CH₃ cyclopentyl231 CH₃ n-C₆H₁₃ 232 CH₃ cyclohexyl 233 CH₃ cyclopropyl-CH₂ 234 CH₃propyn-3-yl 235 CH₃ propen-3-yl 236 CH₃ benzyl 237 CH₃ CH₂CH₂—OCH₃ 238C₂H₅ H 239 C₂H₅ CH₃ 240 C₂H₅ C₂H₅ 241 C₂H₅ n-C₃H₇ 242 C₂H₅ i-C₃H₇ 243C₂H₅ cyclopropyl 244 C₂H₅ n-C₄H₉ 245 C₂H₅ s-C₄H₉ 246 C₂H₅ i-C₄H₉ 247C₂H₅ t-C₄H₉ 248 C₂H₅ n-C₅H₁₁ 249 C₂H₅ i-C₅H₁₁ 250 C₂H₅ neo-C₅H₁₁ 251C₂H₅ cyclopentyl 252 C₂H₅ n-C₆H₁₃ 253 C₂H₅ cyclohexyl 254 C₂H₅cyclopropyl-CH₂ 255 C₂H₅ propyn-3-yl 256 C₂H₅ propen-3-yl 257 C₂H₅benzyl 258 C₂H₅ CH₂CH₂—OCH₃ 259 benzyl H 260 benzyl CH₃ 261 benzyl C₂H₅262 benzyl n-C₃H₇ 263 benzyl i-C₃H₇ 264 benzyl cyclopropyl 265 benzyln-C₄H₉ 266 benzyl s-C₄H₉ 267 benzyl i-C₄H₉ 268 benzyl t-C₄H₉ 269 benzyln-C₅H₁₁ 270 benzyl i-C₅H₁₁ 271 benzyl neo-C₅H₁₁ 272 benzyl cyclopentyl273 benzyl n-C₆H₁₃ 274 benzyl cyclohexyl 275 benzyl cyclopropyl-CH₂ 276benzyl propyn-3-yl 277 benzyl propen-3-yl 278 benzyl benzyl 279 benzylCH₂CH₂—OCH₃ j) R⁴ = 4-N(R^(c))—OR^(d) 280 CO₂CH₃ H 281 CO₂CH₃ CH₃ 282CO₂CH₃ C₂H₅ 283 CO₂CH₃ n-C₃H₇ 284 CO₂CH₃ i-C₃H₇ 285 CO₂CH₃ cyclopropyl286 CO₂CH₃ n-C₄H₉ 287 CO₂CH₃ s-C₄H₉ 288 CO₂CH₃ i-C₄H₉ 289 CO₂CH₃ t-C₄H₉290 CO₂CH₃ n-C₅H₁₁ 291 CO₂CH₃ i-C₅H₁₁ 292 CO₂CH₃ neo-C₅H₁₁ 293 CO₂CH₃cyclopentyl 294 CO₂CH₃ n-C₆H₁₃ 295 CO₂CH₃ cyclohexyl 296 CO₂CH₃cyclopropyl-CH₂ 297 CO₂CH₃ propyn-3-yl 298 CO₂CH₃ propen-3-yl 299 CO₂CH₃benzyl 300 CO₂CH₃ CH₂CH₂—OCH₃ 301 CO₂CH₂CH₃ H 302 CO₂CH₂CH₃ CH₃ 303CO₂CH₂CH₃ C₂H₅ 304 CO₂CH₂CH₃ n-C₃H₇ 305 CO₂CH₂CH₃ i-C₃H₇ 306 CO₂CH₂CH₃cyclopropyl 307 CO₂CH₂CH₃ n-C₄H₉ 308 CO₂CH₂CH₃ s-C₄H₉ 309 CO₂CH₂CH₃i-C₄H₉ 310 CO₂CH₂CH₃ t-C₄H₉ 311 CO₂CH₂CH₃ n-C₅H₁₁ 312 CO₂CH₂CH₃ i-C₅H₁₁313 CO₂CH₂CH₃ neo-C₅H₁₁ 314 CO₂CH₂CH₃ cyclopentyl 315 CO₂CH₂CH₃ n-C₆H₁₃316 CO₂CH₂CH₃ cyclohexyl 317 CO₂CH₂CH₃ cyclopropyl-CH₂ 318 CO₂CH₂CH₃propyn-3-yl 319 CO₂CH₂CH₃ propen-3-yl 320 CO₂CH₂CH₃ benzyl 321 CO₂CH₂CH₃CH₂CH₂—OCH₃ 322 CO₂CH(CH₃)₂ H 323 CO₂CH(CH₃)₂ CH₃ 324 CO₂CH(CH₃)₂ C₂H₅325 CO₂CH(CH₃)₂ n-C₃H₇ 326 CO₂CH(CH₃)₂ i-C₃H₇ 327 CO₂CH(CH₃)₂cyclopropyl 328 CO₂CH(CH₃)₂ n-C₄H₉ 329 CO₂CH(CH₃)₂ s-C₄H₉ 330CO₂CH(CH₃)₂ i-C₄H₉ 331 CO₂CH(CH₃)₂ t-C₄H₉ 332 CO₂CH(CH₃)₂ n-C₅H₁₁ 333CO₂CH(CH₃)₂ i-C₅H₁₁ 334 CO₂CH(CH₃)₂ neo-C₅H₁₁ 335 CO₂CH(CH₃)₂cyclopentyl 336 CO₂C(CH₃)₃ n-C₆H₁₃ 337 CO₂CH(CH₃)₂ cyclohexyl 338CO₂CH(CH₃)₂ cyclopropyl-CH₂ 339 CO₂CH(CH₃)₂ propyn-3-yl 340 CO₂CH(CH₃)₂propen-3-yl 341 CO₂CH(CH₃)₂ benzyl 342 CO₂C(CH₃)₃ H 343 CO₂C(CH₃)₃ CH₃344 CO₂C(CH₃)₃ C₂H₅ 345 CO₂C(CH₃)₃ n-C₃H₇ 346 CO₂C(CH₃)₃ i-C₃H₇ 347CO₂C(CH₃)₃ cyclopropyl 348 CO₂C(CH₃)₃ n-C₄H₉ 349 CO₂C(CH₃)₃ s-C₄H₉ 350CO₂C(CH₃)₃ i-C₄H₉ 351 CO₂C(CH₃)₃ t-C₄H₉ 352 CO₂C(CH₃)₃ n-C₅H₁₁ 353CO₂C(CH₃)₃ i-C₅H₁₁ 354 CO₂C(CH₃)₃ neo-C₅H₁₁ 355 CO₂C(CH₃)₃ cyclopentyl356 CO₂C(CH₃)₃ n-C₆H₁₃ 357 CO₂C(CH₃)₃ cyclohexyl 358 CO₂C(CH₃)₃cyclopropyl-CH₂ 359 CO₂C(CH₃)₃ propyn-3-yl 360 CO₂C(CH₃)₃ propen-3-yl361 CO₂C(CH₃)₃ benzyl 362 CO₂C(CH₃)₃ CH₂CH₂—OCH₃ 363 CH₃ H 364 CH₃ CH₃365 CH₃ C₂H₅ 366 CH₃ n-C₃H₇ 367 CH₃ i-C₃H₇ 368 CH₃ cyclopropyl 369 CH₃n-C₄H₉ 370 CH₃ s-C₄H₉ 371 CH₃ i-C₄H₉ 372 CH₃ t-C₄H₉ 373 CH₃ n-C₅H₁₁ 374CH₃ i-C₅H₁₁ 375 CH₃ neo-C₅H₁₁ 376 CH₃ cyclopentyl 377 CH₃ n-C₆H₁₃ 378CH₃ cyclohexyl 379 CH₃ cyclopropyl-CH₂ 380 CH₃ propyn-3-yl 381 CH₃propen-3-yl 382 CH₃ benzyl 383 CH₃ CH₂CH₂—OCH₃ 384 C₂H₅ H 385 C₂H₅ CH₃386 C₂H₅ C₂H₅ 387 C₂H₅ n-C₃H₇ 388 C₂H₅ i-C₃H₇ 389 C₂H₅ cyclopropyl 390C₂H₅ n-C₄H₉ 391 C₂H₅ s-C₄H₉ 392 C₂H₅ i-C₄H₉ 393 C₂H₅ t-C₄H₉ 394 C₂H₅n-C₅H₁₁ 395 C₂H₅ i-C₅H₁₁ 396 C₂H₅ neo-C₅H₁₁ 397 C₂H₅ cyclopentyl 398C₂H₅ n-C₆H₁₃ 399 C₂H₅ cyclohexyl 400 C₂H₅ cyclopropyl-CH₂ 401 C₂H₅propyn-3-yl 402 C₂H₅ propen-3-yl 403 C₂H₅ benzyl 404 C₂H₅ CH₂CH₃—OCH₃405 benzyl H 406 benzyl CH₃ 407 benzyl C₂H₅ 408 benzyl n-C₃H₇ 409 benzyli-C₃H₇ 410 benzyl cyclopropyl 411 benzyl n-C₄H₉ 412 benzyl s-C₄H₉ 413benzyl i-C₄H₉ 414 benzyl t-C₄H₉ 415 benzyl n-C₅H₁₁ 416 benzyl i-C₅H₁₁417 benzyl neo-C₅H₁₁ 418 benzyl cyclopentyl 419 benzyl n-C₆H₁₃ 420benzyl cyclohexyl 421 benzyl cyclopropyl-CH₂ 422 benzyl propyn-3-yl 423benzyl propen-3-yl 424 benzyl benzyl 425 benzyl CH₂CH₂—OCH₃ No. R⁴ 4262,3-O—CHF—O 427 3,4-O—CHF—O 428 2,3-O—CF₂—O 429 3,4-O—CF₂—O 4302,3-*O—CF₂—CHF—O 431 3,4-•O—CF₂—CHF—O 432 2,3-*O—CHF—CF₂—O 4333,4-•O—CHF—CF₂—O *Linkage site in the 2-position of the R⁴-substitutedphenyl ring •Linkage site in the 3-position of the R⁴-substituted phenylring

The compounds I are suitable as fungicides.

The compounds I are distinguished by an outstanding activity against abroad spectrum of phytopathogenic fungi, in particular from the classesof the Ascomycetes and Basidiomycetes. Some of them act systemically andcan be employed as foliar- and soilacting fungicides.

They are especially important for controlling a large number of fungi ona variety of crop plants such as wheat, rye, barley, oats, rice, maize,grass, cotton, soybeans, coffee, sugar cane, grapevines, fruit species,ornamentals and vegetable species such as cucumbers, beans andcucurbits, and on the seeds of these plants.

Specifically, they are suitable for controlling the following plantdiseases: Erysiphe graminis (powdery mildew) in cereals, Erysiphecichoracearum and Sphaerotheca fuliginea on cucurbits, Podosphaeraleucotricha on apples, Uncinula necator on grapevines, Puccinia specieson cereals, Rhizoctonia species on cotton, rice and lawns, ustilagospecies on cereals and sugar cane, Venturia inaequalis (scab) on apples,Helminthosporium species on cereals, Septoria nodorum on wheat, Botrytiscinerea (gray mold) on strawberries, grapevines, vegetables andornamentals, Cercospora arachidicola on peanuts, Pseudocercosporellaherpotrichoides on wheat, barley, Pyricularia oryzae on rice,Phytophthora infestans on potatoes and tomatoes, Fusarium andVerticillium species on a variety of plants, Plasmopara viticola ongrapevines, Pseudoperonospora species in hops and cucumbers, Alternariaspecies on vegetables and fruit.

The compounds I are applied by treating the fungi, or the plants, seeds,materials or the soil to be protected against fungal infection, with afungicidally active amount of the active ingredients. Application iseffected before or after infection of the materials, plants or seeds bythe fungi.

Using formulation auxiliaries known per se, they can be converted intothe customary formulations (compositions), such as solutions, emulsions,suspensions, dusts, powders, pastes and granules. The use form dependson the intended purpose; in any case, it should guarantee fine anduniform distribution of the compounds I. The formulations are preparedin a known manner, eg. by extending the active ingredient with solventsand/or carriers, if desired using emulsifiers and dispersants, it alsobeing possible for other organic solvents to be used as auxiliarysolvents if water is used as the diluent. Suitable auxiliaries areessentially: solvents such as aromatics (eg. xylene), chlorinatedaromatics (eg. chlorobenzenes), paraffins (eg. mineral oil fractions),alcohols (eg. methanol, butanol), ketones (eg. cyclohexanone), amines(eg. ethanolamine, dimethylformamide) and water; carriers such as groundnatural minerals (eg. kaolins, clays, talc, chalk) and ground syntheticminerals (eg. highly disperse silica, silicates); emulsifiers such asnonionic and anionic emulsifiers (eg. polyoxyethylene fatty alcoholethers, alkylsulfonates and arylsulfonates) and dispersants such aslignin-sulfite waste liquors and methylcellulose.

In general, the fungicidal compositions comprise between 0.1 and 95,preferably between 0.5 and 90, % by weight of active ingredient.

Depending on the nature of the desired effect, the rates of applicationare between 0.01 and 2.0 kg of active ingredient per ha.

In the treatment of seed, amounts of active ingredient of from 0.001 to0.1 g, preferably 0.01 to 0.05 g, are generally required per kilogram ofseed.

In the use form as fungicides, the agents according to the invention canalso be present together with other active ingredients, the [sic] eg.with herbicides, insecticides, growth regulators, fungicides or elsewith fertilizers.

A mixture with fungicides frequently results in a widened spectrum offungicidal action.

The following list of fungicides together with which the compoundsaccording to the invention can be used is intended to illustrate thepossible combinations but not to impose any limitation:

sulfur, dithiocarbamates and their derivatives, such as iron(III)dimethyldithiocarbamate, zinc dimethyldithiocarbamate, zincethylenebisdithiocarbamate, manganese ethylenebisdithiocarbamate,manganese zinc ethylenediaminebisdithiocarbamate, tetramethylthiuramdisulfides [sic], ammonia complex of zinc(N,N-ethylenebisdithiocarbamate), ammonia complex of zinc(N,N′-propylenebisdithiocarbamate), zinc(N,N′-propylenebisdithiocarbamate), N,N′-polypropylenebis(thiocarbamoyl)disulfide; nitro derivatives, such as dinitro(1-methylheptyl)phenylcrotonate, 2-sec-butyl-4,6-dinitrophenyl-3,3-dimethyl acrylate,2-sec-butyl-4,6-dinitrophenylisopropyl carbonate, di-isopropyl5-nitroisophthalate;

heterocyclic substances, such as 2-heptadecyl-2-imidazoline acetate,2,4-dichloro-6-(o-chloroanilino)-s-triazine, O,O-diethylphthalimidophosphonothioate,5-amino-1-[bis-(dimethylamino)-phosphinyl]-3-phenyl-1,2,4-triazole,2,3-dicyano-1,4-dithioanthraquinone,2-thio-1,3-dithiolo[4,5-b]quinoxaline, methyl1-(butylcarbamoyl)-2-benzimidazolecarbamate,2-methoxycarbonylaminobenzimidazole, 2-(furyl-(2))benzimidazole,2-(thiazolyl-(4))benzimidazole,N-(1,1,2,2-tetrachloroethylthio)tetrahydrophthalimide,N-trichloromethylthiotetrahydrophthalimide,N-trichloromethylthiophthalimide,

N-dichlorofluoromethylthio-N′,N′-dimethyl-N-phenylsulfuric diamide,5-ethoxy-3-trichloromethyl-1,2,3-thiadiazole,2-thiocyanomethylthiobenzothiazole, 1,4-dichloro-2,5-dimethoxybenzene,4-(2-chlorophenylhydrazono)-3-methyl-5-isoxazolone, pyridine2-thio-1-oxide, 8-hydroxyquinoline or its copper salt,2,3-dihydro-5-carboxanilido-6-methyl-1,4-oxathiine,2,3-dihydro-5-carboxanilido-6-methyl-1,4-oxathiine 4,4-dioxide,2-methyl-5,6-dihydro-4H-pyran-3-carboxanilide,2-methylfuran-3-carboxanilide, 2,5-dimethylfuran-3-carboxanilide,2,4,5-trimethylfuran-3-carboxanilide,N-cyclohexyl-2,5-dimethylfuran-3-carboxamide,N-cyclohexyl-N-methoxy-2,5-dimethylfuran-3-carboxamide,2-methylbenzanilide, 2-iodobenzanilide, N-formyl-N-morpholine2,2,2-trichloroethyl acetal,piperazine-1,4-diylbis-(1-(2,2,2-trichloroethyl)formamide [sic],1-(3,4-dichloroanilino)-1-formylamino-2,2,2-trichloroethane,2,6-dimethyl-N-tridecyl-morpholine or its salts,2,6-dimethyl-N-cyclododecylmorpholine or its salts,N-[3-(p-tert-butylphenyl)-2-methylpropyl]-cis-2,6-dimethylmorpholine,N-[3-(p-tert-butylphenyl)-2-methylpropyl]piperidine,1-[2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-yl-ethyl]-H-1,2,4-triazole,1-[2-(2,4-dichlorophenyl)-4-n-propyl-1,3-dioxolan-2-yl-ethyl]-1H-1,2,4-triazole,N-(n-propyl)-N-(2,4,6-trichlorophenoxyethyl)-N′-imidazolylurea,1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone,1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol,α-(2-chlorophenyl)-α-(4-chlorophenyl)-5-pyrimidinemethanol,5-butyl-2-dimethylamino-4-hydroxy-6-methylpyrimidine,bis(p-chlorophenyl)-3-pyridinemethanol,1,2-bis(3-ethoxycarbonyl-2-thioureido)benzene,1,2-bis(3-methoxycarbonyl-2-thioureido)benzene,

and a variety of fungicides, such as dodecylguanidine acetate,3-[3-(3,5-dimethyl-2-oxycyclohexyl)-2-hydroxyethyl]glutarimide,hexachlorobenzene, methylN-(2,6-dimethylphenyl)-N-(2-furoyl)-DL-alaninate,DL-N-(2,6-dimethyl-phenyl)-N-(2′-methoxyacetyl)-alanine methyl ester,N-(2,6-dimethylphenyl)-N-chloroacetyl-D,L-2-aminobutyrolactone,DL-N-(2,6-dimethylphenyl)-N-(phenylacetyl)alanine methyl ester,5-methyl-5-vinyl-3-(3,5-dichlorophenyl)-2,4-dioxo-1,3-oxazolidine,3-[3,5-dichlorophenyl(-5-methyl-5-methoxy-methyl]-1,3-oxazolidine-2,4-dione[sic], 3-(3,5-dichlorophenyl)-1-isopropylcarbamoylhydantoin,N-(3,5-dichlorophenyl)-1,2-dimethylcyclopropane-1,2-dicarboximide,2-cyano-[N-(ethylaminocarbonyl)-2-methoximino]acetamide,1-[2-(2,4-dichlorophenyl)-pentyl]-1H-1,2,4-triazole,2,4-difluoro-α-(1H-1,2,4-triazolyl-1-methyl)-benzhydryl alcohol,N-(3-chloro-2,6-dinitro-4-trifluoromethylphenyl)-5-trifluoromethyl-3-chloro-2-aminopyridine,1-((bis(4-fluorophenyl)methylsilyl)methyl)-1H-1,2,4-triazole.

Strobilurins such as methylE-methoximino-[α-(o-tolyloxy)-o-tolyl]acetate, methylE-2-{2-[6-(2-cyanophenoxy)-pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate,N-methyl-E-methoximino-[α-(2-phenoxyphenyl)]acetamide,N-methyl-E-methoximino-[α-(2,5-dimethylphenoxy)-o-tolyl]acetamide.

Anilinopyrimidines, such as N-(4,6-dimethylpyrimidin-2-yl)aniline,N-[4-methyl-6-(1-propynyl)pyrimidin-2-yl]aniline,N-(4-methyl-6-cyclopropylpyrimidin-2-yl)aniline.

Phenylpyrroles, such as4-(2,2-difluoro-1,3-benzodioxol-4-yl)pyrrole-3-carbonitrile.

Cinnamamides, such asN-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-acryloylmorpholine.

(2RS,3RS)-1-[3-(2-Chlorophenyl)-2-[4-fluorophenyl]oxiran-2-yl-methyl]1H-1,2,4-triazole[sic].

Moreover, the compounds of the formula I are suitable for efficientlycontrolling pests from the classes of the insects, arachnids andnematodes. They can be employed as pesticides in crop protection and inthe hygiene, stored-product and veterinary sectors.

The harmful insects include, from the order of the lepidopterans(Lepidoptera), for example, Agrotis ypsilon, Agrotis segetum, Alabamaargillacea, Anticarsia gemmatalis, Argyresthia conjugella, Autographagamma, Bupalus piniarius, Cacoecia murinana, Capua reticulana,Cheimatobia brumata, Choristoneura fumiferana, Choristoneuraoccidentalis, Cirphis unipuncta, Cydia pomonella, Dendrolimus pini,Diaphania nitidalis, Diatraea grandiosella, Earias insulana,Elasmopalpus lignosellus, Eupoecilia ambiguella, Evetria bouliana,Feltia subterranea, Galleria mellonella, Grapholitha funebrana,Grapholitha molesta, Heliothis armigera, Heliothis virescens, Heliothiszea, Hellula undalis, Hibernia defoliaria, Hyphantria cunea, Hyponomeutamalinellus, Keiferia lycopersicella, Lambdina fiscellaria, Laphygmaexigua, Leucoptera coffeella, Leucoptera scitella, Lithocolletisblancardella, Lobesia botrana, Loxostege sticticalis, Lymantria dispar,Lymantria monacha, Lyonetia clerkella, Malacosoma neustria, Mamestrabrassicae, Orgyia pseudotsugata, Ostrinia nubilalis, Panolis flammea,Pectinophora gossypiella, Peridroma saucia, Phalera bucephala,Phthorimaea operculella, Phyllocnistis citrella, Pieris brassicae,Plathypena scabra, Plutella xylostella, Pseudoplusia includens,Rhyacionia frustrana, Scrobipalpula absoluta, Sitotroga cerealella,Sparganothis pilleriana, Spodoptera frugiperda, Spodoptera littoralis,Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana,Trichoplusia ni, Zeiraphera canadensis.

From the order of the beetles (Coleoptera), for example, Agrilussinuatus, Agriotes lineatus, Agriotes obscurus, Amphimallussolstitialis, Anisandrus dispar, Anthonomus grandis, Anthonomus pomorum,Atomaria linearis, Blastophagus piniperda, Blitophaga undata, Bruchusrufimanus, Bruchus pisorum, Bruchus lentis, Byctiscus betulae, Cassidanebulosa, Cerotoma trifurcata, Ceuthorrhynchus assimilis,Ceuthorrhynchus napi, Chaetocnema tibialis, Conoderus vespertinus,Crioceris asparagi, Diabrotica longicornis, Diabrotica 12-punctata,Diabrotica virgifera, Epilachna varivestis, Epitrix hirtipennis,Eutinobothrus brasiliensis, Hylobius abietis, Hypera brunneipennis,Hypera postica, Ips typographus, Lema bilineata, Lema melanopus,Leptinotarsa decemlineata, Limonius californicus, Lissorhoptrusoryzophilus, Melanotus communis, Meligethes aeneus, Melolonthahippocastani, Melolontha melolontha, Oulema oryzae, Ortiorrhynchussulcatus, Otiorrhynchus ovatus, Phaedon cochleariae, Phyllotretachrysocephala, Phyllophaga sp., Phyllopertha horticola, Phyllotretanemorum, Phyllotreta striolata, popillia japonica, Sitona lineatus,sitophilus granaria.

From the order of the dipterans (Diptera), for example, Aedes aegypti,Aedes vexans, Anastrepha ludens, Anopheles maculipennis, Ceratitiscapitata, Chrysomya bezziana, Chrysomya hominivorax, Chrysomyamacellaria, Contarinia sorghicola, Cordylobia anthropophaga, Culexpipiens, Dacus cucurbitae, Dacus oleae, Dasineura brassicae, Fanniacanicularis, Gasterophilus intestinalis, Glossina morsitans, Haematobiairritans, Haplodiplosis equestris, Hylemyia platura, Hypoderma lineata,Liriomyza sativae, Liriomyza trifolii, Lucilia caprina, Lucilia cuprina,Lucilia sericata, Lycoria pectoralis, Mayetiola destructor, Muscadomestica, Muscina stabulans, Oestrus ovis, Oscinella frit, Pegomyahysocyami, Phorbia antiqua, Phorbia brassicae, Phorbia coarctata,Rhagoletis cerasi, Rhagoletis pomonella, Tabanus bovinus, Tipulaoleracea, Tipula paludosa.

From the order of the thrips (Thysanoptera), for example, Frankliniellafusca, Frankliniella occidentalis, Frankliniella tritici, Scirtothripscitri, Thrips oryzae, Thrips palmi, Thrips tabaci.

From the order of the hymenopterans (Hymenoptera), for example, Athaliarosae, Atta cephalotes, Atta sexdens, Atta texana, Hoplocampa minuta,Hoplocampa testudinea, Monomorium pharaonis, Solenopsis geminata,Solenopsis invicta.

From the order of the heteropterans (Heteroptera), for example,Acrosternum hilare, Blissus leucopterus, Cyrtopeltis notatus, Dysdercuscingulatus, Dysdercus intermedius, Eurygaster integriceps, Euschistusimpictiventris, Leptoglossus phyllopus, Lygus lineolaris, Lyguspratensis, Nezara viridula, Piesma quadrata, Solubea insularis, Thyantaperditor.

From the order of the homopterans (Homoptera), for example,Acyrthosiphon onobrychis, Adelges laricis, Aphidula nasturtii, Aphisfabae, Aphis pomi, Aphis sambuci, Brachycaudus cardui, Brevicorynebrassicae, Cerosipha gossypii, Dreyfusia nordmannianae, Dreyfusiapiceae, Dysaphis radicola, Dysaulacorthum pseudosolani, Empoasca fabae,Macrosiphum avenae, Macrosiphum euphorbiae, Macrosiphon rosae, Megouraviciae, Metopolophium dirhodum, Myzodes persicae, Myzus cerasi,Nilaparvata lugens, Pemphigus bursarius, Perkinsiella saccharicida,Phorodon humuli, Psylla mali, Psylla piri, Rhopalomyzus ascalonicus,Rhopalosiphum maidis, Sappaphis mala,Sappaphis mali, Schizaphisgraminum, Schizoneura lanuginosa, Trialeurodes vaporariorum, Viteusvitifolii.

From the order of the termites (Isoptera), for example, Calotermesflavicollis, Leucotermes flavipes, Reticulitermes lucifugus, Termesnatalensis.

From the order of the orthopterans (Orthoptera), for example, Achetadomestica, Blatta orientalis, Blattella germanica, Forficulaauricularia, Gryllotalpa gryllotalpa, Locusta migratoria, Melanoplusbivittatus, Melanoplus femur-rubrum, Melanoplus mexicanus, Melanoplussanguinipes, Melanoplus spretus, Nomadacris septemfasciata, Periplanetaamericana, Schistocerca americana, Schistocerca peregrina, Stauronotusmaroccanus, Tachycines asynamorus.

From the class of the Arachnoidea, for example, arachnids (Acarina),such as Amblyomma americanum, Amblyomma variegatum, Argas persicus,Boophilus annulatus, Boophilus decoloratus, Boophilus microplus,Brevipalpus phoenicis, Bryobia praetiosa, Dermacentor silvarum,Eotetranychus carpini, Eriophyes sheldoni, Hyalomma truncatum, Ixodesricinus, Ixodes rubicundus, Ornithodorus moubata, Otobius megnini,Paratetranychus pilosus, Dermanyssus gallinae, Phyllocoptruta oleivora,Polyphagotarsonemus latus, Psoroptes ovis, Rhipicephalus appendiculatus,Rhipicephalus evertsi, Sarcoptes scabiei, Tetranychus cinnabarinus,Tetranychus kanzawai, Tetranychus pacificus, Tetranychus telarius,Tetranychus urticae.

From the class of the nematodes, for example, root-knot nematodes, eg.Meloidogyne hapla, Meloidogyne incognita, Meloidogyne javanica,cyst-forming nematodes, eg. Globodera rostochiensis, Heterodera avenae,Heterodera glycines, Heterodera schachtii, Heterodera trifolii, stemeelworms and foliar nematodes, eg. Belonolaimus longicaudatus,Ditylenchus destructor, Ditylenchus dipsaci, Heliocotylenchusmulticinctus, Longidorus elongatus, Radopholus similis, Rotylenchusrobustus, Trichodorus primitivus, Tylenchorhynchus claytoni,Tylenchorhynchus dubius, Pratylenchus neglectus, Pratylenchus penetrans,Pratylenchus curvitatus, Pratylenchus goodeyi.

The compounds I, as such, in the form of their formulations(compositions) which have been obtained using formulation auxiliariesknown per se or in the form of the use forms prepared therefrom, can beapplied by spraying, atomizing, dusting, spreading or pouring, forexample in the form of directly sprayable solutions, powders,suspensions or dispersions, emulsions, oil dispersions, pastes, dusts,materials for spreading, or granules. The use forms depend entirely onthe intended purposes; in any case, they should guarantee the finestpossible distribution of the active ingredients according to theinvention.

The concentrations of active ingredient in the ready-to-use preparationscan be varied within substantial ranges.

They are in general between 0.0001 and 10%, preferably between 0.01 and1%.

The active ingredients can also be used very successfully in theultra-low volume method (ULV), it being possible to apply formulationscomprising over 95% by weight of active ingredient, or even the activeingredient without additives.

The rate of application of active ingredient for controlling pests isfrom 0.1 to 2.0, preferably 0.2 to 1.0, kg/ha under field conditions.

Substances which are suitable for the preparation of directly sprayablesolutions, emulsions, pastes or oil dispersions are mineral oilfractions of medium to high boiling point, such as kerosene or dieseloil, furthermore coal tar oils and oils of vegetable or animal origin,aliphatic, cyclic and aromatic hydrocarbons, eg. benzene, toluene,xylene, paraffin, tetrahydronaphthalene, alkylated naphthalenes or theirderivatives, methanol, ethanol, propanol, butanol, chloroform, carbontetrachloride, cyclohexanol, cyclohexanone, chlorobenzene, isophorone,and strongly polar solvents, eg. dimethylformamide, dimethyl sulfoxide,N-methylpyrrolidone and water.

Aqueous use forms can be prepared from emulsion concentrates, pastes orwettable powders (sprayable powders, oil dispersions) by adding water.To prepare emulsions, pastes or oil dispersions, the substances, as suchor dissolved in an oil or solvent, can be homogenized in water by meansof wetting agent, tackifier, dispersant or emulsifier. Alternatively, itis possible to prepare concentrates composed of active substance,wetting agent, tackifier, dispersant or emulsifier and, if desired, oilor solvent, and these concentrates are suitable for dilution with water.

Suitable surfactants are alkali metal, alkaline earth metal and ammoniumsalts of lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonicacid, dibutylnaphthalenesulfonic acid, or alkylarylsulfonates, alkylsulfates, alkylsulfonates, fatty alcohol sulfates and fatty acids andtheir alkali metal and alkaline earth metal salts, salts of sulfatedfatty alcohol glycol ether, condensates of sulfonated naphthalene andnaphthalene derivatives with formaldehyde, condensates of naphthalene,or of naphthalenesulfonic acid, with phenol and formaldehyde,polyoxyethylene octylphenol [sic] ether, ethoxylated isooctylphenol,octylphenol, nonylphenol, alkylphenol [sic] polyglycol ethers,tributylphenyl polyglycol ether, alkylaryl polyether alcohols,isotridecyl alcohol, fatty alcohol/ethylene oxide condensates,ethoxylated castor oil, polyoxyethylene alkyl ethers, ethoxylatedpolyoxypropylene, lauryl alcohol polyglycol ether acetal, sorbitolesters, ligninsulfite waste liquors and methylcellulose.

Powders, materials for spreading and dusts can be prepared by mixing orconcomitantly grinding the active substances together with a solidcarrier.

In general, the formulations comprise from 0.01 to 95% by weight,preferably from 0.1 to 90% by weight, of the active ingredient. Theactive ingredients are employed in a purity of from 90% to 100%,preferably 95% to 100% (according to the NMR spectrum).

The following are examples of formulations:

I. 5 parts by weight of a compound I according to the invention 25 aremixed intimately with 95 parts by weight of finely divided kaolin. Thisgives a dust which comprises 5% by weight of the active ingredient.

II. 30 parts by weight of a compound I according to the invention aremixed intimately with a mixture of 92 parts by weight of puverulentsilica gel and 8 parts by weight of paraffin oil which had been sprayedonto the surface of this silica gel. This gives a preparation of theactive ingredient with good adhesion properties (comprises 23% by weightof active ingredient).

III. 10 parts by weight of a compound I according to the invention aredissolved in a mixture composed of 90 parts by weight of xylene, 6 partsby weight of the adduct of 8 to 10 mol of ethylene oxide and 1 mol ofoleic acid N-monoethanolamide, 2 parts by weight of calciumdodecylbenzenesulfonate and 2 parts by weight of the adduct of 40 mol ofethylene oxide and 1 mol of castor oil (comprises 9% by weight of activeingredient).

IV. 20 parts by weight of a compound I according to the invention aredissolved in a mixture composed of 60 parts by weight of cyclohexanone,30 parts by weight of isobutanol, 5 parts by weight of the adduct of 7mol of ethylene oxide and 1 mol of isooctylphenol and 5 parts by weightof the adduct of 40 mol of ethylene oxide to 1 mol of castor oil(comprises 16% by weight of active ingredient).

V. 80 parts by weight of a compound I according to the invention aremixed thoroughly with 3 parts by weight of sodiumdiisobutylnaphthalene-alpha-sulfonate, 10 parts by weight of the sodiumsalt of a lignosulfonic acid from a sulfite waste liquor and 7 parts byweight of pulverulent silica gel, and the mixture is ground in a hammermill (comprises 80% by weight of active ingredient).

VI. 90 parts by weight of a compound I according to the invention aremixed with 10 parts by weight of N-methyl-α-pyrrolidone, resulting in asolution which is suitable for use in the form of microdrops (comprises90% by weight of active ingredient).

VII. 20 parts by weight of a compound I according to the invention aredissolved in a mixture composed of 40 parts by weight of cyclohexanone,30 parts by weight of isobutanol, 20 parts by weight of the adduct of 7mol of ethylene oxide and 1 mol of isooctylphenol and 10 parts by weightof the adduct of 40 mol of ethylene oxide to 1 mol of castor oil.Pouring the solution into 100,000 parts by weight of water and finelydistributing it therein gives an aqueous dispersion which comprises0.02% by weight of the active ingredient.

VIII. 20 parts by weight of a compound I according to the invention aremixed thoroughly with 3 parts by weight of sodiumdiisobutylnaphthalene-α-sulfonate, 17 parts by weight of the sodium saltof a lignosulfonic acid from a sulfite waste liquor and 60 parts byweight of pulverulent silica gel, and the mixture is ground in a hammermill. Finely distributing the mixture in 20,000 parts by weight of watergives a spray mixture which comprises 0.1% by weight of the activeingredient.

Granules, eg. coated granules, impregnated granules and homogeneousgranules, can be prepared by binding the active ingredients to solidcarriers. Examples of solid carriers are mineral earths, such as silicagel, silicas, silica gels [sic], silicates, talc, kaolin, attaclay,limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth,calcium sulfate, magnesium sulfate, magnesium oxide, ground syntheticmaterials, fertilizers, eg. ammonium sulfate, ammonium phosphate,ammonium nitrate, ureas, and products of vegetable origin, such ascereal meal, tree bark meal, wood meal and nutshell meal, cellulosepowders, and other solid carriers.

Various types of oils, or herbicides, fungicides, other pesticides, orbactericides, can be added to the active ingredients, if desired onlyimmediately prior to use (tank mix). These agents can be admixed withthe agents according to the invention in a weight ratio of 1:10 to 10:1.

SYNTHESIS EXAMPLE 1 Synthesis of Compound I.11 of Table 1

1a) Synthesis of

162 g (1.2 mol) of AlCl₃ were added, a little at a time, to a stirredmixture of 82 g (0.45 ml) of pivalanilide and 40 g (0.43 mol) ofpropionyl chloride, during which process the temperature of the reactionmixture climbed to approximately 100° C. and hydrochloric acid wasevolved.

The reaction mixture was subsequently stirred for 6 hours at 80° C. Thereaction mixture was carefully poured onto ice, and the aqueous phasewas extracted with methyl t-butyl ether and ethyl acetate.

The combined organic phases were extracted 2× with water, and theaqueous phase was dried over MgSO₄ and concentrated. The residue waspurified by column chromatography with cyclohexane/ethyl acetatemixtures. This gave 22.3 g (22%) of the title Compound 1a as a colorlesssolid (m.p.=121° C.).

¹H NMR (CDCl₃; δ in ppm): 7.95 (d, 2H, phenyl); 7.65 (d, broad, 3H, NH,2×phenyl); 2.95 (q, 2H, CH₂); 1.35 (s, 9H, t-butyl); 1.2 (t, 3H, CH₃).

1b) Synthesis of

A mixture of 22 g (94 mmol) of Compound la in 200 ml of toluene wastreated at −20° C. with 80 ml of hydrochloric acid solution in ether(approximately 4N) and 12 g (115 mmol) of n-butyl nitrite in 50 ml ofether are subsequently added dropwise. The mixture was then stirredovernight at room temperature. The title compound crystallized out ofthe reaction mixture. The solid which had precipitated was filtered offwith suction, washed with methyl t-butyl ether, ethyl acetate andmethylene chloride and dried in a stream of nitrogen. This gave 17 g(69%) of the title Compound 1b as a colorless solid (m.p. 198° C.).Work-up of the mother liquor yielded a second crystal fraction of 3.5 g(14%).

¹H NMR (DMSO-d₆; δ in ppm): 12.3; 9.5 (2s, in each case 1H, OH, NH);7.85 (d, 2H, phenyl); 7.75 (d, 2H, phenyl); 2.0 (s, 3H, CH₃); 1.25 (s,9H, t-butyl).

1c) Synthesis of

A mixture of 16 g (61 mmol) of Compound 1b, 12 g (150 mmol) of pyridineand 6.5 g (78 mmol) of O-methylhydroxylamine hydrochloride in 100 ml ofmethanol was stirred overnight at room temperature. The reaction mixturewas subsequently concentrated and the residue taken up in methylenechloride. The organic phase was washed with dilute hydrochloric acid andwater, dried over MgSO₄ and concentrated. The residue crystallized andwas obtained by stirring with methylene chloride. This gave 3.6 g (20%)of the title Compound 1c as a colorless solid (m.p.=208° C.). Work-up ofthe mother liquor yielded a second crystal fraction of 5.2 g of 1c(29%).

¹H NMR (DMSO-d₆; δ in ppm): 11.6; 9.25 (2s, in each case 1H, OH, NH);7.6 (d, 2H, phenyl); 7.1 (d, 2H, phenyl); 3.8 (s, 3H, OCH₃); 2.05 (s,3H, CH₃); 1.25 (s, 9H, t-butyl).

Synthesis of I.11

A mixture of 2 g (6.8 mmol) of the Compound 1c and 0.25 g (10 mmol) ofsodium hydride in 20 ml of dimethylformamide was stirred for 15 minutesat room temperature. 2 g (7 mmol) of methyl2-bromomethylphenylglyoxylate trans-O-methyloxime (EP 254 426) weresubsequently added, and the mixture was stirred for one hour at roomtemperature. The reaction mixture was then diluted with water and theaqueous phase extracted with methyl t-butyl ether. The combined organicphases were washed with water, dried over MgSO₄ and concentrated. Theresidue crystallized, and the crystals were filtered off with suctionand dried in a stream of nitrogen. This gave 2.8 g (83%) of the titleCompound I.11 as a pale yellow solid (m.p.=114-116° C.).

¹H NMR (CDCl₃-d₆; δ in ppm): 7.55; (2s, 2H, phenyl); 7.4 (m, 4H,phenyl); 7.15 (d, broad, NH, 2×phenyl); 4.95 (s, 2H, OCH₂); 4.0; 3.9;3.8 (3s, in each case 3H, 3×OCH₃); 2.1 (s, 3H, CH₃); 1.25 (s, 9H,t-butyl).

SYNTHESIS EXAMPLE 2 Synthesis of Compound I.12 of Table 1

A mixture of 1.5 g (3 mmol) of Compound I.11 of Synthesis Example 1 and0.1 g (4 mmol) of sodium hydride in 20 ml of dimethylformamide wasstirred for 10 minutes at room temperature. 0.7 g (5 mmol) of methyliodide was subsequently added and the mixture was stirred at roomtemperature for approximately 2 hours. The reaction mixture wassubsequently diluted with water and the aqueous phase extracted withmethyl t-butyl ether. The combined organic phases were extracted withwater, dried over MgSO₄ and concentrated. The residue was purified bycolumn chromatography with cyclohexane/ethyl acetate mixture. This gave1.2 g (78%) of the title Compound I.12 as pale yellow crystals(m.p.=111-113° C.).

¹H NMR (CDCl₃; δ in ppm): 7.35; (m, 2H, phenyl); 7.2 (m, 6H, phenyl);4.9 (s, 2H, OCH₂); 4.0; 3.9; 3.8 (3s, in each case 3H, 3×OCH₃); 3.2 (s,3H, NCH₃); 2.1 (s, 3H, CH₃); 1.05 (s, 9H, t-butyl).

SYNTHESIS EXAMPLE 3 Synthesis of Compound I.10 of Table 1

A mixture of 0.9 g (1.8 mmol) of Compound I.12 of Synthesis Example 2and 3 ml of tetrahydrofuran in 20 ml of 40% strength methylaminesolution was stirred for 1 hour at 50° C. Excess methylamine wassubsequently evaporated in vacuo and the remaining aqueous phase wasextracted with methylene chloride. The combined organic phases werewashed with water, dried over MgSO₄ and concentrated. The residuecrystallized and was obtained by stirring with methyl t-butyl ether.This gave 0.7 g (76%) of the title Compound I.10 as a colorless solidm.p.=168-170° C.).

¹H NMR (CDCl₃; δ in ppm): 7.35; (m, 2H, phenyl); 7.2 (m, 6H, phenyl);6.75 (s, broad, 1H, NH); 4.9 (s, 2H, OCH₂); 3.9 (2s, in each case 3H,2×OCH₃); 3.2 (s, 3H, NCH₃); 2.9 (d, 3H, HNCH₃); 2.1 (s, 3H, CH₃); 1.05(s, 9H, t-butyl).

SYNTHESIS EXAMPLE 4 Synthesis of Compound I.52 of Table 1

4a. Synthesis of

17.5 g (0.21 mol) of O-methylhydroxylamine hydrochloride were added to asolution of 20 g (0.14 mol) of 4-cyanoacetophenone in 200 ml ofmethanol, and the mixture was first stirred for 2 hours at roomtemperature and subsequently for 2 hours at 60° C. The reaction mixturewas poured onto water and extracted with methyl tert-butyl ether. Thecombined organic phases were washed with water, dried over Na₂SO₄ andconcentrated. The residue was purified by column chromatography onsilica gel (n-hexane). This gave 23.3 g (97% yield) of Compound 4a as awhite powder (m.p.=58-60° C.).

¹H NMR (CDCl₃; δ in ppm): 2.21 (s, 3H); 4.02 (s, 3H); 7.61-7.75 (AA′BB′,4H).

4b. Synthesis of

At −15° C., 53 ml (0.15 mol) of an ethylmagnesium bromide solution (3Min diethyl ether) was added dropwise to a solution of 17.6 g (0.10 mol)of Compound 4a in 200 ml of tetrahydrofuran, and the reaction mixturewas allowed to come to room temperature and was subsequently heated for2.5 hours at 40° C. The reaction mixture was cooled to 0-5° C.,hydrolyzed with 100 ml of ice-water and brought to pH=6 with glacialacetic acid. After a further addition of water, the mixture wasextracted with methyl tert-butyl ether, and the organic phase was washedwith water, dried over Na₂SO₄ and concentrated. The residue was purifiedby column chromatography on silica gel (n-hexane). This gave 13.9 g (67%yield) of Compound 4b as a pale yellow powder (m.p.=75-77° C.).

¹H NMR (CDCl₃; δ in ppm): 1.23 (t, 3H); 2.24 (s, 3H); 3.00 (q, 2H); 4.02(s, 3H); 7.71-7.95 (AA′BB′,4H).

4c) Synthesis of

80 ml of saturated HCl solution in ether were added at −20° C. to 13.2 g(0.064 mol) of Compound 4b in 150 ml of toluene. At this temperature, asolution of 7.3 g (0.071 mol) of n-butyl nitrite in 60 ml of diethylether was subsequently added dropwise. The mixture was stirred for 1hour at −10° C. and subsequently allowed to come to room temperature.After a total of 16 hours, the reaction batch was washed with ice-waterand subsequently extracted with 1M sodium hydroxide solution. Thealkaline phase was separated off and rendered neutral with 20% strengthsulfuric acid. The batch was subsequently extracted with methylenechloride, and the organic phase was washed with water, dried over Na₂SO₄and concentrated. The residue was dissolved in a small amount ofmethylene chloride and purified by column chromatography on silica gel(n-hexane). This gave 13.2 g (88% yield) of Compound 4c as a colorlessoil.

¹H NMR (CDCl₃; δ in ppm): 2.16 (s, 3H); 2.24 (s, 3H); 4.03 (s, 3H);7.66-7.88 (AA′BB′,4H); 8.92 (s, br, 1H).

4d) Synthesis of

5 g (0.021 mol) of Compound 4c in 100 ml of methanol and 5 g of pyridinewere treated with a solution of 2.7 g (0.032 mol) ofO-methylhydroxylamine hydrochloride in 20 ml of methanol. The reactionmixture was stirred for 16 hours at room temperature and subsequentlyfor 2 hours at 60° C. The reaction batch was poured into a mixture ofmethyl tert-butyl ether and 10% strength hydrochloric acid and extractedwith methyl tert-butyl ether. The combined organic phases were washedwith 10% hydrochloric acid and water, dried over Na₂SO₄ andconcentrated. The residue was dissolved in 100 ml of toluene and treatedwith 0.9 g (6.3 mmol) AlCl₃. After 5 hours at 40° C. and a further 12hours at room temperature, the reaction mixture was added to a mixtureof ethyl acetate and 10% hydrochloric acid. The mixture was extractedwith ethyl acetate and the organic phase was washed with water, driedover Na₂SO₄ and concentrated. After triturating the residue withmethanol, 3.7 g (66% yield) of Compound 4d were obtained as a paleyellow powder (m.p.=162-165° C.).

¹H NMR (CDCl₃; δ in ppm): 2.11 (s, 3H); 2.21 (s, 3H); 3.89 (s, 3H); 3.99(s, 3H); 7.15-7.67 (AA′BB′,4H); 8.43 (s, 1H).

4e) Synthesis of Compound I.51 of Table 1

A solution of 3.0 g (11.4 mmol) of Compound 4d in 50 ml ofN,N-dimethylformamide was treated with 2.1 g (11.4 mmol) of 30% strengthsodium methoxide solution (in methanol) and stirred for 15 minutes atroom temperature. After the addition of 3.3 g (11.4 mmol) of methyl2-bromomethylphenylglyoxylate trans-O-methyloxime (EP 254 426) in 30 mlof N,N-dimethylformamide, the mixture was stirred for 0.5 hour at roomtemperature. The mixture was subsequently poured into ice-water andextracted with methyl tert-butyl ether. The organic phase was washedwith water, dried over Na₂SO₄ and concentrated. Crystallization of theresidue from methanol gave 4.7 g (88% yield) of the title Compound I.51as colorless crystals (m.p.=112-114° C.).

¹H NMR (CDCl₃; δ in ppm): 2.10 (s, 3H); 2.22 (s, 3H); 3.82 (s, 3H); 3.90(s, 3H); 3.99 (s, 6H); 4.90 (s, 2H); 7.08-7.60 (m, 8H).

4f) Synthesis of Compound I.52 of Table 1

A solution of 2.0 g (4.3 mmol) of Compound 4e in 50 ml oftetrahydrofuran was treated with 3.3 g of 40% strength aqueousmonomethylamine solution and stirred for 24 hours at room temperature.The resulting reaction mixture was treated with water and extracted withmethyl tert-butyl ether. The organic phase was washed, dried andconcentrated under reduced pressure. Purification of the residue bycolumn chromatography on silica gel (methyl tert-butylether/n-hexane=1/1) gave 1.7 g (85% yield) of the title compound as acolorless oil.

¹H NMR (CDCl₃; δ in ppm): 2.10 (s, 3H); 2.22 (s, 3H); 3.87 (d, 3H); 3.90(s, 6H); 3.99 (s, 3H); 4.92 (s, 2H); 6.67 (s, br, 1H); 7.12-7.61 (m,8H).

Compounds I.1-I.9, I.13-I.50 and I.53-I.59, which are listed in Table 1below, were prepared by similar methods.

The melting points (m.p.) are given in ° C., the IR bands in cm⁻¹ andthe ¹H NMR data in ppm relative to CDCl₃ as the standard.

TABLE 1 No. X Y R⁵ (R⁴)_(n) M.P./IR/NMR I.1. NOCH₃ O CH₃ 4-NH—COCH₃63-66 I.2. NOCH₃ NH CH₃ 4-NH—COCH₃ 173-174 I.3. NOCH₃ NH CH₃ 4-NH—COC₂H₅200 I.4. NOCH₃ O CH₃ 4-N(CH₃)—COC₂H₅ 129-130 I.5. NOCH₃ NH CH₃4-N(CH₃)—COC₂H₅ 128-129 I.6. NOCH₃ O CH₃ 4-NH—COC₂H₅ 58-60 I.7. NOCH₃ OCH₃ 4-N(C₂H₅)—COC₂H₅ 138-140 I.8. NOCH₃ NH CH₃ 4-N(C₂H₅)—COC₂H₅ 93-95I.9. NOCH₃ NH CH₃ 4-NH—CO-t-C₄H₉ 219-220 I.10. NOCH₃ NH CH₃4-N(CH₃)—CO-t-C₄H₉ 168-170 I.11. NOCH₃ O CH₃ 4-NH—CO-t-C₄H₉ 114-116I.12. NOCH₃ O CH₃ 4-N(CH₃)—CO-t-C₄H₉ 111-113 I.13. CHOCH₃ O CH₃4-NH—CO-t-C₄H₉ 126-130 I.14. NOCH₃ O CH₃ 4-N(n-C₃H₇)—CO—C₂H₅ 123-126I.15. NOCH₃ NH CH₃ 4-N(n-C₃H₇)—CO—C₂H₅ 125-127 I.16. CHOCH₃ O CH₃4-NH—CO—C₂H₅ 125-128 I.17. CHOCH₃ O CH₃ 4-N(CH₃)—CO—C₂H₅ 140-141 I.18.CHOCH₃ O CH₃ 4-N(C₂H₅)—CO—C₂H₅ 137-140 I.19. CHOCH₃ O CH₃4-N(n-C₃H₇)—CO—C₂H₅ 119-121 I.20. CHCH₃ O CH₃ 4-NH—CO—C₂H₅ 103-105 I.21.CHCH₃ O CH₃ 4-N(CH₃)—CO—C₂H₅ 83-86 I.22. CHCH₃ O CH₃ 4-N(C₂H₅)—CO—C₂H₅111-112 I.23. CHCH₃ O CH₃ 4-N(n-C₃H₇)—CO—C₂H₅ 105-107 I.24. NOCH₃ NH CH₃4-NH—CO—OCH₃-3-OCH₃ 143-145 I.25. NOCH₃ NH CH₃ 4-N(OCH₃)—CO—OCH₃1730,1677,1525,1508,1441,1337, 1305,1037,1012,978 I.26. NOCH₃ NH CH₃4-N(C₂H₅)—CO-t-C₄H₉ 163-164 I.27. NOCH₃ NH CH₃ 4-N(n-C₄H₉)—CO-t-C₄H₉77-82 I.28. NOCH₃ O CH₃ 4-N(OCH₃)—CO—OCH₃ 163-164 I.29. NOCH₃ NH CH₃4-N(CH₃)—CO—CH₃ 148-149 I.30. NOCH₃ NH CH₃ 4-N(C₂H₅)—CO—CH₃ 131-133I.31. NOCH₃ NH CH₃ 4-N(n-C₃H₇)—CO—CH₃ 2936,1662,1606,1524,1508,1397,1067,1037,1006,978 I.32. NOCH₃ NH CH₃ 4-N(n-C₃H₇)—CO-t-C₄H₉1675,1633,1601,1527,1508,1037, 1009,999,977,870 I.33. CHOCH₃ O CH₃4-NH—CO—CH₃ 171-174 I.34. CHOCH₃ O CH₃ 4-N(CH₃)—CO—CH₃ 135-137 I.35.CHOCH₃ O CH₃ 4-N(C₂H₅)—CO—CH₃ 131-133 I.36. CHOCH₃ O CH₃4-N(n-C₃H₇)—CO—CH₃ 130-131 I.37. CHOCH₃ O CH₃ 4-N(CH₃)—CO-t-C₄H₉ 105-106I.38. CHOCH₃ O CH₃ 4-N(C₂H₅)—CO-t-C₄H₉ 117-118 I.39. CHCH₃ O CH₃4-NH—CO—CH₃ 124-126 I.40. CHCH₃ O CH₃ 4-N(CH₃)—CO—CH₃ 87-89 I.41. CHCH₃O CH₃ 4-N(C₂H₅)—CO—CH₃ 104-106 I.42. CHCH₃ O CH₃ 4-N(n-C₃H₇)—CO—CH₃1716,1660,1507,1397,1257,1248, 1063,997,878,750 I.43. CHCH₃ O CH₃4-NH—CO-t-C₄H₉ 94-97 I.44. CHCH₃ O CH₃ 4-N(CH₃)—CO-t-C₄H₉1717,1640,1605,1508,1364,1353, 1253,1209,1068,1007 I.45. CHCH₃ O CH₃4-N(C₂H₅)—CO-t-C₄H₉ 86-88 I.46. NOCH₃ O CH₃ 4-N(CH₃)—CO—CH₃ 140-141I.47. NOCH₃ O CH₃ 4-N(C₂H₅)—CO—CH₃ 99-100 I.48. NOCH₃ O CH₃4-N(n-C₃H₇)—CO—CH₃ 104-105 I.49. NOCH₃ O CH₃ 4-N(C₂H₅)—CO-t-C₄H₉ 114-115I.50. NOCH₃ O CH₃ 4-N(OCO₂CH₃)—CO—OCH₃ 155 I.51. NOCH₃ O CH₃4-C(CH₃)═NOCH₃ 112-114 I.52. NOCH₃ NH CH₃ 4-C(CH₃)═NOCH₃ 51-54 I.53.NOCH₃ O CH₃ 4-CH═NOCH₃ 123-125 I.54. NOCH₃ NH CH₃ 4-CH═NOCH₃ 100-101I.55. NOCH₃ NH CH₃ 4-C(CH₃)═NOC₂H₅ 3350,2973,2936,1676,1524,1091,1066,1048,1005,979,895 I.56. CHOCH₃ O CH₂C≡CH 4-C(CH₃)═NOC₂H₅3280,2929,1708,1634,1285,1256, 1130,1112,1048,1004,919 I.57. CHOCH₃ OCH₂C≡CH 4-C(CH₃)═NOCH₃ 3280,2930,1708,1634,1284,1256,1130,1112,1068,1048,1006,892, I.58. CHCH₃ O CH₃ 4-CH═NOCH₃2938,1716,1435,1253,1209,1053, 1008,922,895,760 I.59. CHOCH₃ O CH₃4-CH═NOCH₃ 2939,1709,1634,1284,1256,1130, 1112,1055,1003,921

USE EXAMPLES

The fungicidal activity of the compounds of the formula I isdemonstrated by the following experiments:

The active ingredients are formulated as a 20% strength emulsion in amixture of 70% by weight of cyclohexanone, 20% by weight of Nekanil® LN(Lutensol® AP6, wetting agent having emulsifier and dispersing actionbased on ethoxylated alkylphenols) and 10% by weight of Emulphor® EL(Emulan® EL, emulsifier based on ethoxylated fatty alcohols) and dilutedwith water to give the desired concentration. The experiments wereevaluated visually.

The activity of the compounds of the general formula I against animalpests is demonstrated by the following experiments.

The active ingredients are formulated

a) as a 0.1% strength solution in acetone or

b) as a 10% strength emulsion in a mixture of 70% by weight ofcyclohexanone, 20% by weight of Nekanil® LN (Lutensol® AP6, wettingagent with emulsifier and dispersing action based on ethoxylatedalkylphenols) and 10% by weight of Emulphor® EL (Emulan® EL, emulsifierbased on ethoxylated fatty alcohols)

and diluted to give the desired concentration, using acetone in the caseof a) and water in the case of b).

USE EXAMPLE 1 Efficacy Against Powdery Mildew of Wheat

Leaves of wheat seedlings cv. “Frühgold” in pots were sprayed withaqueous spray mixture comprising 80% of active ingredient of Table 1 and20% of emulsifier in the dry matter and, 24 hours after the spraycoating had dried on, dusted with oidia (spores) of powdery mildew ofwheat (Erysiphe graminis var. tritici). The test plants weresubsequently placed in a greenhouse at from 20 to 22° C. and a relativeatmospheric humidity of 75 to 80%. After 7 days, the extent of mildewdevelopment was determined.

TABLE 2 % infection of the leaves after application of an aqueouspreparation comprising Active ingredient of Table 1 250 ppm of activeingredient I.20 15 I.21  5 I.22 15 I.23 15 I.40 15 I.41 15 I.43 15 I.4515 I.58  0 Comparison substance A (No. 1433 30 of Table 3 in WO95/21153) No. I.13  0 No. I.16  5 No. I.17 15 No. I.18  5 No. I.19  5No. I.57  0 No. I.59  0 Comparison substance B (No. 2 of 30 Table II inWO 95/21153) Comparison substance C (No. 1433 30 of Table 1 in WO95/21153) No. I.12  5 No. I.53 15 Comparison substance D (No. 48 of 30Table 1 in WO 95/21153) Comparison substance E (No. 1901 60 of Table 7in WO 95/21153) No. I.5  5 No. I.8  0 No. I.15  5 No. I.25  5 No. I.2615 No. I.27  5 No. I.31 15 No. I.32 15 No. I.52 15 No. I.54  5 No. I.5515 Comparison substance F (No. 1898 30 of Table 5 in WO 95/21254)Untreated 70

USE EXAMPLE 2 Efficacy Against Leaf Rust of Wheat

Leaves of wheat seedlings cv. “Kanzler” in pots were dusted with leafrust spores (Puccinia recondite). The pots were then placed for 24 hoursin a chamber with high atmospheric humidity (90 to 95%) at from 20 to22° C. During this time, the spores germinated, and the germ tubespenetrated the leaf tissue. The infected plants were subsequentlysprayed to runoff point with aqueous spray mixtures comprising 80% ofactive ingredient of Table 1 and 20% of emulsifier in the dry matter.After the spray coating had dried on, the test plants were placed in agreenhouse at from 20 to 22° C. and a relative atmospheric humidity of65 to 70%. After 8 days, the extent of rust development on the leaveswas determined.

TABLE 3 % infection of the leaves after application of an aqueouspreparation comprising Active ingredient . . . ppm of active ingredient63 ppm No. I.40  0 No. I.41 15 No. I.43  5 No. I.44  5 No. I.45 15 No.I.58  0 Comparison substance A (No. 1433 40 of Table 3 in WO 95/21153)No. I.13 15 No. I.56 15 No. I.57 15 No. I.59 10 Comparison substance B(No. 2 of 60 Table II in WO 95/21153) Comparison substance C (No. 143340 of Table 1 in WO 95/21153) 63 ppm No. I.12 15 Comparison substance D(No. 48 of 70 Table I in WO 95/21153) Comparison substance E (No. 190140 of Table 7 in WO 95/21153) No. I.5  0 No. I.8  0 16 ppm No. I.13  5No. I.27  3 No. I.29  5 No. I.30 15 No. I.31  0 No. I.32  0 No. I.52  0No. I.54  0 No. I.55  0 Comparison product F (No. 1898 60 of Table 5 inWO 95/21154) Untreated 70

We claim:
 1. A phenylacetic acid compound of formula I

where the variables have the following meanings: X is NOCH₃, CHOCH₃ orCHCH₃; Y is O or NH; R¹ is methyl; R² is cyano, nitro, trifluoromethyl,halogen, C₁-C₄-alkyl or C₁-C₄-alkoxy; m is 0, 1 or 2, it being possiblefor the radicals R² to be different if m is 2; R³ is hydrogen, cyano,C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy or cyclopropyl; R⁴ isC₁-C₄-alkylenedioxy, the alkylene groups being partially or fullyhalogenated, or is one of the radicals: —C(═NOR^(a))—A_(p)—R^(b),—NR^(b)—(C═O)—A_(p)—R^(a), —O—(C═O)—NR^(a)R^(b) or —N(R^(c))—OR^(d),where R^(a), R^(b) independently of one another are hydrogen or in eachcase unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl,cycloalkenyl, heterocyclyl, aryl or hetaryl, R^(c), R^(d) independentlyof one another are hydrogen or in each case unsubstituted or substitutedalkyl, alkenyl, alkynyl, alkylcarbonyl, alkenylcarbonyl,alkynylcarbonyl, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl,cycloalkyl, cycloalkylcarbonyl, cycloalkoxycarbonyl, arylcarbonyl orhetarylcarbonyl, p is 0 or 1 and A is oxygen, sulfur or nitrogen, thenitrogen having attached to it hydrogen or C₁-C₆-alkyl; n is 1 or 2, itbeing possible for the radicals R⁴ to be different is n is 2; R⁵ ishydrogen, C₁-C₆-alkylsulfonyl, C₁-C₆-alkyl, C₃-C₆-alkenyl,C₃-C₆-alkynyl, it being possible for these radicals to be partially orfully halogenated and/or to have attached to them one to three of thefollowing groups: cyano, nitro, hydroxyl, mercapto, amino, carboxyl,aminocarbonyl, aminothiocarbonyl, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₁-C₆-alkylsulfonyl,C₁-C₆-alkylsulfoxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, C₁-C₆-alkylamino,di-C₁-C₆-alkylamino, C₂-C₆-alkenyloxy, C₃-C₆-cycloalkyl,C₃-C₆-cycloalkoxy, heterocyclyl, heterocyclyloxy, aryl, aryloxy,arylthio, hetaryl, hetaryloxy, hetarylthio, it being possible for thecyclic groups, in turn, to be partially or fully halogenated and/or tohave attached to them one to three of the following substituents: cyano,nitro, hydroxyl, mercapto, amino, carboxyl, aminocarbonyl,aminothiocarbonyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,C₁-C₆-alkylsulfonyl, C₁-C₆-alkylsulfoxyl, C₃-C₆-cycloalkyl,C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio,C₁-C₆-alkylamino, di-C₁-C₆-alkylami no, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy,benzyl, benzyloxy, aryl, aryloxy, arylthio, hetaryl, hetaryloxy,hetarylthio and C₃-C₆-alkynyloxy; C₃-C₆-cycloalkyl, which can bepartially or fully halogenated and/or, independently of each other, canhave attached to it one to three of the following groups: cyano,C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl, C₁-C₆-alkoxy andC₁-C₆-alkylthio, or a salt thereof.
 2. A process for the preparation ofthe compound of formula I defined in claim 1, which comprises reacting abenzyl compound of formula II

where L¹ is a nucleophilically exchangeably leaving group with ahydroxyimine of formula III


3. A process for the preparation of the compound of formula I defined inclaim 1, which comprises reacting a benzyl compound of formula II

with a dihydroxyimine of formula IV

to give a compound of formula V

and subsequently reacting V with a compound of formula VI R⁵—L²  (VI)where L² is a nucleophilically exchangeable leaving group to give I. 4.A process for preparing the compound of formula I defined in claim 1,which comprises reacting a benzyl compound of formula II

with a carbonylhydroxyimine of formula VII

to give a compound of formula VIII

and subsequently reacting VIII a) first with hydroxylamine or a saltthereof and then with a compound of formula VI R⁵—L²  (VI) where L² is anucleophilically exchangeable leaving group, or b) with a hydroxylamineor a hydroxylammonium salt of formula IXa or IXb

where Q^(⊖) is the anion of an acid.
 5. A composition against animalpests or harmful fungi, which comprises customary additives and aneffective amount of the compound of formula I defined in claim
 1. 6. Thecomposition defined in claim 5 for controlling animal pests from theclasses of insects, arachnids or nematodes.
 7. A method of controllinganimal pests or harmful fungi, which comprises treating the pests or theharmful fungi, their environment, or the plants, areas, materials orspaces to be kept free from them, with an effective amount of thecompound of formula I defined in claim
 1. 8. A compound of formula VIII

where X is NOCH₃, CHOCH₃ or CHCH₃; Y is O or NH; R¹ is methyl; R² iscyano, nitro, trifluoromethyl, halogen, C₁-C₄-alkyl or C₁-C₄-alkoxy; mis 0, 1 or 2, it being possible for the radicals R² to be different if mis 2; R³ is hydrogen, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxyor cyclopropyl; R⁴ is C₁-C₄-alkylenedioxy, the alkylene groups beingpartially or fully halogenated, or is one of the radicals:—C(═NOR^(a))—A_(p)—R^(b), —NR^(b)—(C═O)—A_(p)—R^(a),—O—(C═O)—NR^(a)R^(b) or —N(R^(c))—OR^(d), where R^(a), R^(b)independently of one another are hydrogen or in each case unsubstitutedor substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl,heterocyclyl, aryl or hetaryl, R^(c), R^(d) independently of one anotherare hydrogen or in each case unsubstituted or substituted alkyl,alkenyl, alkynyl, alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl,alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, cycloalkyl,cycloalkylcarbonyl, cycloalkoxycarbonyl, arylcarbonyl orhetarylcarbonyl, p is 0 or 1 and A is oxygen, sulfur or nitrogen, thenitrogen having attached to it hydrogen or C₁-C₆-alkyl; n is 1 or 2, itbeing possible for the radicals R⁴ to be different is n is
 2. 9. Thecompound of formula I defined in claim 1, wherein R^(a), R^(b)independently of one another are hydrogen or in each case unsubstitutedor substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl oraryl, R^(c), R^(d) independently of one another are hydrogen or in eachcase unsubstituted or substituted alkyl, alkenyl, alkynyl,alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, alkoxycarbonyl,alkenyloxycarbonyl, alkynyloxycarbonyl, cycloalkyl, cycloalkylcarbonyl,cycloalkoxycarbonyl or arylcarbonyl, R⁵ is hydrogen,C₁-C₆-alkylsulfonyl, C₁-C₆-alkyl, C₃-C₆-alkenyl, C₃-C₆-alkynyl, it beingpossible for these radicals to be partially or fully halogenated and/orto have attached to them one to three of the following groups: cyano,nitro, hydroxyl, mercapto, amino, carboxyl, aminocarbonyl,aminothiocarbonyl, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₁-C₆-alkylsulfonyl,C₁-C₆-alkylsulfoxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, C₁-C₆-alkylamino,di-C₁-C₆-alkylamino, C₂-C₆-alkenyloxy, C₃-C₆-cycloalkyl,C₃-C₆-cycloalkoxy, aryl, aryloxy and arylthio, it being possible for thecyclic groups, in turn, to be partially or fully halogenated and/or tohave attached to them one to three of the following substituents: cyano,nitro, hydroxyl, mercapto, amino, carboxyl, aminocarbonyl,aminothiocarbonyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,C₁-C₆-alkylsulfonyl, C₁-C₆-alkylsulfoxyl, C₃-C₆-cycloalkyl,C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio,C₁-C₆-alkylamino, di-C₁-C₆-alkylamino, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy,benzyl, benzyloxy, aryl, aryloxy, arylthio and C₃-C₆-alkynyloxy;C₃-C₆-cycloalkyl, which can be partially or fully halogenated and/or,independently of each other, can have attached to it one to three of thefollowing groups: cyano, C₁-C₆-alkyl C₁-C₆-haloalkyl, C₂-C₆-alkenyl,C₁-C₆-alkoxy and C₁-C₆-alkylthio, or a salt thereof.
 10. The compound offormula I defined in claim 1, wherein R³ is hydrogen, cyclopropyl,methyl, ethyl, 1-methylethyl, methoxy, cyano or trifluoromethyl.
 11. Thecompound of formula I defined in claim 1, wherein the radical R^(a) orthe radical R^(b) is selected from the group consisting of C₁-C₆-alkyland C₂-C₆-alkenyl.
 12. The compound of formula I defined in claim 1,wherein R⁵ is hydrogen, C₃-C₆-cycloalkyl, arylalkyl, hetarylalkyl,aryloxyalkyl or hetaryloxyalkyl.
 13. The compound of formula I definedin claim 1, wherein X is NOCH₃.
 14. A phenylacetic acid compound offormula I

wherein X is NOCH₃, CHOCH₃ or CHCH₃; Y is O or NH; R¹ is methyl; R² iscyano, nitro, trifluoromethyl, halogen, C₁-C₄-alkyl or C₁-C₄-alkoxy; mis 0, 1 or 2, it being possible for the radicals R² to be different if mis 2; R³ is hydrogen, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxyor cyclopropyl; R⁴ is C₁-C₄-alkylenedioxy, the alkylene groups beingpartially or fully halogenated, or is a radical—C(═NOR^(a))—A_(p)—R^(b), wherein R^(a), R^(b) independently of oneanother are hydrogen or in each case unsubstituted or substituted alkyl,alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl orhetaryl, p is 0 or 1 and A is oxygen, sulfur or nitrogen, the nitrogenhaving attached to it hydrogen or C₁-C₆-alkyl; n is 1 or 2, it beingpossible for the radicals R⁴ to be different is n is 2; R⁵ is hydrogen,C₁-C₆-alkylsulfonyl, C₁-C₆-alkyl, C₃-C₆-alkenyl, C₃-C₆-alkynyl, it beingpossible for these radicals to be partially or fully halogenated and/orto have attached to them one to three of the following groups: cyano,nitro, hydroxyl, mercapto, amino, carboxyl, aminocarbonyl,aminothiocarbonyl, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₁-C₆-alkylsulfonyl,C₁-C₆-alkylsulfoxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, C₁-C₆-alkylamino,di-C₁-C₆-alkylamino, C₂-C₆-alkenyloxy, C₃-C₆-cycloalkyl,C₃-C₆-cycloalkoxy, heterocyclyl, heterocyclyloxy, aryl, aryloxy,arylthio, hetaryl, hetaryloxy, hetarylthio, it being possible for thecyclic groups, in turn, to be partially or fully halogenated and/or tohave attached to them one to three of the following substituents: cyano,nitro, hydroxyl, mercapto, amino, carboxyl, aminocarbonyl,aminothiocarbonyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,C₁-C₆-alkylsulfonyl, C₁-C₆-alkylsulfoxyl, C₃-C₆-cycloalkyl,C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio,C₁-C₆-alkylamino, di-C₁-C₆-alkylamino, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy,benzyl, benzyloxy, aryl, aryloxy, arylthio, hetaryl, hetaryloxy,hetarylthio and C₃-C₆-alkynyloxy; C₃-C₆-cycloalkyl, which can bepartially or fully halogenated and/or, independently of each other, canhave attached to it one to three of the following groups: cyano,C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl, C₁-C₆-alkoxy andC₁-C₆-alkylthio, or a salt thereof.
 15. The compound of formula Idefined in claim 38, wherein R^(a), R^(b) independently of one anotherare hydrogen or in each case unsubstituted or substituted alkyl,alkenyl, alkynyl, cycloalkyl, cycloalkenyl or aryl, R⁵ is hydrogen,C₁-C₆-alkylsulfonyl, C₁-C₅-alkyl, C₃-C₆-alkenyl, C₃-C₆-alkynyl, it beingpossible for these radicals to be partially or fully halogenated and/orto have attached to them one to three of the following groups: cyano,nitro, hydroxyl, mercapto, amino, carboxyl, aminocarbonyl,aminothiocarbonyl, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₁-C₆-alkylsulfonyl,C₁-C₆-alkylsulfoxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, C₁-C₆-alkylamino,di-C₁-C₆-alkylamino, C₂-C₆-alkenyloxy, C₃-C₆-cycloalkyl,C₃-C₆-cycloalkoxy, aryl, aryloxy and arylthio, it being possible for thecyclic groups, in turn, to be partially or fully halogenated and/or tohave attached to them one to three of the following substituents: cyano,nitro, hydroxyl, mercapto, amino, carboxyl, aminocarbonyl,aminothiocarbonyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,C₁-C₆-alkylsulfonyl, C₁-C₆-alkylsulfoxyl, C₃-C₆-cycloalkyl,C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio,C₁-C₆-alkylamino, di-C₁-C₆-alkylamino, C₁-C₆-alkylaminocarbonyl,di-C₁-C₆-alkylaminocarbonyl, C₁-C₆-alkylaminothiocarbonyl,di-C₁-C₆-alkylaminothiocarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkenyloxy,benzyl, benzyloxy, aryl, aryloxy, arylthio and C₃-C₆-alkynyloxy;C₃-C₆-cycloalkyl, which can be partially or fully halogenated and/or,independently of each other, can have attached to it one to three of thefollowing groups: cyano, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl,C₁-C₆-alkoxy and C₁-C₆-alkylthio, or a salt thereof.
 16. A compositionagainst animal pests or harmful fungi, which comprises customaryadditives and an effective amount of the compound of formula I definedin claim
 38. 17. A method of controlling animal pests or harmful fungi,which comprises treating the pests or the harmful fungi, theirenvironment, or the plants, areas, materials or spaces to be kept freefrom them, with an effective amount of the compound of formula I definedin claim
 1. 18. A compound of formula VIII

wherein X is NOCH₃, CHOCH₃ or CHCH₃; Y is O or NH; R¹ is methyl; R² iscyano, nitro, trifluoromethyl, halogen, C₁-C₄-alkyl or C₁-C₄-alkoxy; mis 0, 1 or 2, it being possible for the radicals R² to be different if mis 2; R³ is hydrogen, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxyor cyclopropyl; R⁴ is C₁-C₄-alkylenedioxy, the alkylene groups beingpartially or fully halogenated, or is a radical—C(═NOR^(a))—A_(p)—R^(b), wherein R^(a), R^(b) independently of oneanother are hydrogen or in each case unsubstituted or substituted alkyl,alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl orhetaryl, p is 0 or 1 and A is oxygen, sulfur or nitrogen, the nitrogenhaving attached to it hydrogen or C₁-C₆-alkyl; n is 1 or 2, it beingpossible for the radicals R⁴ to be different is n is 2.